Peripheral nerve scaffold and preparation method of same

Abstract

The invention discloses a peripheral nerve scaffold including an external sleeve tube and packing disposed therein. The packing is a three-dimensional framework formed by reeling a yarn mesh made frombio-ink. The invention also discloses a preparation method of the peripheral nerve scaffold. The peripheral nerve scaffold has the bionic factors, such as structure and composition, of the natural peripheral nerve; on the basis that the magnesium alloy external sleeve tube guarantees biocompatibility, the scaffold has sufficient structural stability. During manufacturing, the packing can reduce the demand on shaping strength of ink, so that selection range of the packing is enlarged, and more bio-functions may be achieved in the ink. The two-dimensional yarn mesh is formed through 3D-printing, and then the yarn meshes are stacked or reeled to form the packing framework, wherein structure and permeability of same can be accurately regulated. The framework is infused or infiltrated with special functional components, so that the packing has corresponding biological features, e.g. promoting growth of axons or promoting vascularization.

Description

technical field [0001] The invention relates to the technical field of tissue engineering and bionic structures, in particular to a peripheral nerve support and a preparation method thereof. Background technique [0002] The anatomical structure of the peripheral nerve is complex, which is divided into epineurium area, nerve fascicular area and interfascicular area, etc. There are also functional structures such as microvessels and connective tissue distributed in each area. In addition, the composition and spatial distribution of different regions are also very complex. Nerve repair materials (or catheters) currently reported in the literature are mainly prepared from a single homogeneous material (such as synthetic materials, natural materials, and acellular matrix materials). According to the principle of nerve regeneration, the structure and composition of the catheter have also been bionically designed (such as Gradient distribution of nerve growth factor, etc.), but t...

AI Technical Summary

Problems solved by technology

Although the thermoplastic degradable polyether ester material has a mature printing process and is stable after printing, its mechanical properties are quite different from those of peripheral nerves, and it is difficult to load cells or active proteins under high temperature printing conditions

However, bio-ink materials suitable for cell growth are generally low in strength and poor in stability, and it is difficult to meet the needs of direct printing and stability in later use.

At present, there is no relatively complete process for 3D printing peripheral nerve scaffolds using hydrogel ink materials with good biocompatibility.

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