Florfenicol soluble powder and preparation method thereof

A florfenicol and soluble technology, applied in the field of florfenicol soluble powder and its preparation, can solve the problem that the antibacterial effect of the drug does not significantly help and improve, affects product dispersion, dissolution speed and release speed, and clinical use. Inconvenience and other problems, to achieve the effect of prolonging the action time of the drug, avoiding the low bulk density of conventional production, and prolonging the action time

Inactive Publication Date: 2018-12-11
王琴
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The absorption accelerators involved in the patent formula, such as sodium carboxymethylcellulose, methylcellulose, and sodium alginate, are very slow to disperse even in hot water, and the addition amount is more than 10%, and the expansion multiple is relatively large. Production requires a lot of water, low capacity and high cost
Furthermore, this type of absorption enhancer will seriously affect the dispersion, dissolution rate and release rate of the product in water, and it does not significantly help and improve the antibacterial effect of the drug, which is inconvenient for clinical use.

Method used

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  • Florfenicol soluble powder and preparation method thereof
  • Florfenicol soluble powder and preparation method thereof
  • Florfenicol soluble powder and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0033] If produce 100kg florfenicol soluble powder, comprise the following steps:

[0034] (1) Weigh 21.5kg of Florfenicol, 63.9kg and 11.6kg of beta-cyclodextrin and hydroxypropyl-beta-cyclodextrin respectively (according to active ingredients), 1.5kg of trimethoprim, propylene glycol block 1kg polyether, 0.5kg dimethyl sulfoxide, spare;

[0035] (2) Put trimethoprim and Florfenicol into distilled water, stir and dissolve to obtain a mixed solution; then mix the mixed solution, beta-cyclodextrin and hydroxypropyl-beta-cyclodextrin evenly, and mix the liquid Heating to 83.5°C while stirring continuously can obtain molecular inclusion liquid, the ratio of water to material is 2:1;

[0036] (3) When the temperature of the molecular inclusion liquid in step (2) is stable at 83.5°C, put in propylene glycol block polyether and dimethyl sulfoxide, stir and keep warm for 1 hour after clarification, and then use a centrifugal spray dryer to centrifuge Spray drying treatment; further...

Embodiment 2

[0048] If produce 100kg florfenicol soluble powder, comprise the following steps:

[0049] (1) Weigh 21.5kg of Florfenicol, 63.9kg and 11.6kg of beta-cyclodextrin and hydroxypropyl-beta-cyclodextrin respectively (according to active ingredients), 1.5kg of trimethoprim, propylene glycol block 0.5kg each of polyether and polyethylene glycol monomethyl ether, 0.3kg each of sodium succinate and glycerin, spare;

[0050] (2) Put trimethoprim and Florfenicol into distilled water, stir and dissolve to obtain a mixed solution; then mix the mixed solution, beta-cyclodextrin, and hydroxypropyl-beta-cyclodextrin evenly, and heat the liquid To 81 ℃ while stirring continuously to obtain molecular inclusion liquid, the ratio of water to material is 2:1;

[0051] (3) When the temperature of the molecular inclusion liquid in step (2) is stable at 81°C, add propylene glycol block polyether, polyethylene glycol monomethyl ether, sodium succinate and glycerin, stir and keep warm for 1 hour afte...

Embodiment 3

[0053] If produce 100kg florfenicol soluble powder, comprise the following steps:

[0054] Take by weighing Florfenicol 26.5kg, beta cyclodextrin and hydroxypropyl beta cyclodextrin are respectively 59.1kg and 11.8kg (according to active ingredient), trimethoprim 0.8kg, propylene glycol block polyether and 0.5kg each of polyethylene glycol monomethyl ether, 0.4kg each of dimethyl sulfoxide and glycerin, for standby;

[0055] (2) Put trimethoprim and Florfenicol into distilled water, stir and dissolve to obtain a mixed solution; then mix the mixed solution, beta-cyclodextrin, and hydroxypropyl-beta-cyclodextrin evenly, and heat the liquid To 81.5 ℃ while stirring continuously to obtain molecular inclusion liquid, the ratio of water to material is 2:1;

[0056] (3) When the temperature of the molecular inclusion liquid in step (2) is stable at 81.5°C, add propylene glycol block polyether, polyethylene glycol monomethyl ether, sodium succinate and glycerin, stir and keep warm for ...

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Abstract

The invention discloses a florfenicol soluble powder and a preparation method thereof. The florfenicol soluble powder comprises the following components in parts by weight: 21.5-26.5 parts of florfenicol, 70.9-75.5% of inclusion agent, 0.8-1.5% of trimethoprim, 0.8-1 part of dispersing agent and 0.5-0.8 part of latent solvent. According to the florfenicol soluble powder and the preparation methodthereof disclosed by the invention, a molecular inclusion technology is adopted for solving the insoluble problem of florfenicol in water and greatly promoting the bioavailability of the product; through the improvement of technological parameters, the bulk density of common centrifugal spray technical products can be increased and the bulk density of products can reach up to the level more suitable for fodder enterprises and cultivation terminals; the product liquidity is promoted, the usage amount of packing materials is saved and the obvious social and economic benefits are created.

Description

technical field [0001] The invention belongs to the field of veterinary drug preparations, in particular to a florfenicol soluble powder and a preparation method thereof. Background technique [0002] Florfenicol, also known as florfenicol, is an excellent broad-spectrum antibiotic for animals. It has the characteristics of broad antibacterial spectrum, good absorption, wide distribution in the body, safety and high efficiency, especially eliminates chloramphenicol that destroys bone marrow and hematopoiesis. Functional shortcomings, no potential aplastic anemia, teratogenic, carcinogenic and mutagenic effects. In veterinary medicine, it is widely used in the treatment of livestock and poultry bacterial diseases caused by sensitive bacteria, and the effect is remarkable. There is no problem of chloramphenicol residue, and it is not easy to produce drug resistance. It is the best substitute for thiamphenicol. However, the raw material of florfenicol is almost insoluble in wa...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/14A61K47/69A61K31/165A61K31/505A61P31/04
CPCA61K9/14A61K31/165A61K31/505A61K47/6951A61P31/04A61K2300/00
Inventor 王琴杨彩梅杨彪詹鹏飞曾新福
Owner 王琴
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