Medicinal composition containing diosmin sulfate derivatives and application thereof

A technology of xylanin sulfate and its composition, which is applied to the pharmaceutical composition containing diosmin sulfate derivatives and its application field, can solve the problems of antagonist toxicity, etc., and achieve the goal of alleviating poisoning symptoms and restoring liver function damage Effect

Active Publication Date: 2018-12-14
XIANGBEI WELMAN PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, acute poisoning generally excretes the poison through emesis, gastric lavage, catharsis and other means; there are also specific antagonis

Method used

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  • Medicinal composition containing diosmin sulfate derivatives and application thereof
  • Medicinal composition containing diosmin sulfate derivatives and application thereof
  • Medicinal composition containing diosmin sulfate derivatives and application thereof

Examples

Experimental program
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Embodiment 1

[0040] Embodiment 1 The preparation of formula I compound of the present invention

[0041]

[0042] The diosin sulfate derivatives represented by formula I provided by the present invention include metal salts of diosin sulfate and metal complexes of diosin sulfate. In formula I, R is SO 3 M, R1 is selected from H or SO 3 M, wherein M is a metal ion or a metal complex group.

[0043] For the preparation method of the compound of formula I, reference may be made to European Patent EP0302155 and European Patent EP0558435, the entire contents of which are incorporated herein by reference. Referring to the following reaction formula, using Diosmin as raw material, after sulfation and alkalization, the metal salt of diosmin sulfate is obtained, that is, R=SO 3 M, R1=H or SO 3 The compound of formula I of M, wherein M can be a common metal ion, such as sodium ion, potassium ion, calcium ion, aluminum ion or magnesium ion, and different metal salts can be obtained by selectin...

Embodiment 2

[0050] Embodiment 2 pharmaceutical composition of the present invention-tablet

[0051] Prescription: compound three 500g, microcrystalline cellulose 30g, hypromellose 20.2g, polyvinylpyrrolidone 10.3g, magnesium stearate 3.5g. Preparation method: Take compound three and microcrystalline cellulose, make soft material with 5% hypromellose ethanol solution, granulate, dry, add sodium carboxymethyl starch and magnesium stearate, compress into tablets, and prepare 1000 pieces.

Embodiment 3

[0052] Embodiment 3 pharmaceutical composition of the present invention-capsule

[0053] Prescription: compound two 500g, microcrystalline cellulose 30g, silicon dioxide 10g. Preparation method: take compound 2, microcrystalline cellulose, and silicon dioxide, mix well, sieve, pack into capsules, and make 1000 capsules.

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Abstract

The invention provides a medicinal composition containing diosmin sulfate derivatives and application thereof. The derivatives or the medicinal composition thereof can be used for preventing or treating toxication. The diosmin derivatives and the medicinal composition which are provided by the invention have excellent detoxication, can obviously reduce toxication caused by various factors, effectively recover the impaired liver function, and provide a new medicine selection for clinically preventing or treating toxication or peptic ulcer combined toxication.

Description

technical field [0001] The invention relates to a pharmaceutical composition containing diosmin sulfate derivatives, and also relates to the application of the pharmaceutical composition. Background technique [0002] Poisoning refers to the process in which foreign substances (toxic substances) enter the human body and react with tissues, causing temporary or permanent damage to tissue functions. [0003] After toxic substances enter the human body, they often damage important organs and systems, such as the gastrointestinal tract, liver, kidneys, and nervous system. As the largest metabolic organ in the human body, the liver is said to have the function of "detoxification". But because of this, the liver also bears most of the damage that poisons do to the body. [0004] Poisoning is very common in everyday life. In addition to causing gastrointestinal reactions such as diarrhea and vomiting, toxic food can more seriously cause damage to internal organs. Excessive alco...

Claims

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Application Information

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IPC IPC(8): A61K31/7048A61P1/04A61P39/02
CPCA61K31/7048A61P1/04A61P39/02
Inventor 孙明杰
Owner XIANGBEI WELMAN PHARMA CO LTD
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