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Acrylic resin bone cement capable of continuously and efficiently releasing antibiotics, and preparation method thereof

A technology of acrylic resin and bone cement, which is used in pharmaceutical formulations, medical science, prostheses, etc. to achieve obvious effects, bacteriostatic effects, and sustained and efficient release.

Inactive Publication Date: 2018-12-14
SHANGHAI INSTITUTE OF TECHNOLOGY
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  • Abstract
  • Description
  • Claims
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AI Technical Summary

Problems solved by technology

This therapy has also achieved good results in the treatment of osteomyelitis and open wounds. However, the application of antibiotic bone cement involves several problems: the local antibiotic concentration must exceed the minimum inhibitory concentration; the antibiotic bone cement must have a Relatively high drug concentration and slow release of antibiotics to the local area over the next few days and weeks
However, ordinary antibiotic bone cement can only be effectively released in a short period of time, and the total amount of release is generally lower than 5% of the added amount. How to achieve sustained and efficient release has become the focus of research in this field

Method used

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  • Acrylic resin bone cement capable of continuously and efficiently releasing antibiotics, and preparation method thereof
  • Acrylic resin bone cement capable of continuously and efficiently releasing antibiotics, and preparation method thereof

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preparation example Construction

[0016] The preparation method of the acrylic resin bone cement for sustained and high-efficiency release of antibiotics comprises the following steps:

[0017] (1) Preparation of SBA-15 carrier: 3-5g of P123 (polyethylene oxide-polypropylene oxide-polyethylene oxide triblock copolymer) dissolved in 20-50g water and 100-140g, 2M Add 6-10g of tetraethyl orthosilicate to the hydrochloric acid aqueous solution under stirring, react at 30-40°C for 20h, then stand at 80-120°C for 12h, and wash the obtained solid with water and absolute ethanol until medium SBA-15 is obtained by drying at 100°C for 10-20h and calcining in air at 500°C for 6-8h.

[0018] (2) Preparation of PEG-modified SBA-15 carrier: Dissolve 0-0.05g PEG in 5-10mL water, add 0.25-5g mesoporous molecular sieve SBA-15, stir evenly, heat to evaporate water, and vacuum dry.

[0019] (3) Preparation of drug-loaded filling materials: Dissolve 60-100 mg of gentamicin in 4-8 mL of water, add the PEG-modified SBA-15 carrier...

Embodiment 2

[0027] Preparation of SBA-15 carrier: 4g of P123 (polyethylene oxide-polypropylene oxide-polyethylene oxide triblock copolymer) was dissolved in 30g water and 120g, 2M hydrochloric acid aqueous solution, and then added under stirring 8g of tetraethyl orthosilicate, reacted at 35°C for 20h, then stood at 100°C for 12h, washed the obtained solid with water and absolute ethanol until neutral, dried at 100°C for 15h, and calcined in air at 500°C for 6h to obtain SBA-15.

[0028] Preparation of the drug-loaded filling material: Dissolve 80 mg of gentamicin in 6 mL of water, add 0.25 g of SBA-15 carrier, stir for 24 hours, and dry at 80° C. for 12 hours to obtain the drug-loaded filling material.

[0029] Preparation of antibacterial bone cement: dope 10wt.% drug-loaded filling material in acrylic resin bone cement powder, mix and stir for 20 minutes to obtain solid phase bone cement powder, and then mix according to the needs of every 2g of solid phase mixture. The proportion of t...

Embodiment 3

[0033] Preparation of PEG-modified SBA-15 carrier: Dissolve 0.025g PEG in 5mL water, add 0.25g mesoporous molecular sieve SBA-15, stir evenly, heat to evaporate water, cool naturally and then vacuum dry.

[0034] Preparation of the drug-loaded filling material: Dissolve 80 mg of gentamicin in 6 mL of water, add the PEG-modified SBA-15 carrier prepared above, stir for 24 hours, and dry at 80° C. for 12 hours to obtain the drug-loaded filling material.

[0035] Preparation of antibacterial bone cement: dope 10wt.% drug-loaded filling material in acrylic resin bone cement powder, mix and stir for 20 minutes to obtain solid phase bone cement powder, and then mix according to the needs of every 2g of solid phase mixture. The ratio of the liquid phase of the bone cement is 1g, and the liquid phase monomer of the bone cement is added to the prepared bone cement solid phase mixture, stirred for 40 seconds to obtain a uniform slurry, and the antibacterial bone cement is obtained after c...

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Abstract

The invention relates to the field of biomedical materials, and concretely relates to an acrylic resin bone cement capable of continuously and efficiently releasing antibiotics. A preparation method of the acrylic resin bone cement comprises the following steps: preparing a PEG-modified SBA-15 carrier by using SBA-15 as a carrier and PEG as a modifier, loading gentamicin to the PEG modified SBA-15carrier in order to obtain a drug-loaded filler material, doping an acrylic resin bone cement powder with 5-15 wt% of the drug-loaded filler material, mixing the bone cement powder and the drug-loaded filler material, performing stirring to obtain a solid phase bone cement powder, adding a bone cement liquid phase to the obtained bone cement solid phase mixture, performing stirring to obtain a uniform slurry, and solidifying the uniform slurry to obtain the antibacterial acrylic resin bone cement. Compared with traditional antibiotic bone cements in the prior art, the acrylic resin bone cement capable of continuously and efficiently releasing antibiotics has the advantages of high release amount, lastingness, and significant antibacterial effect on Staphylococcus aureus and Escherichia coli.

Description

[technical field] [0001] The invention relates to the field of biomedical materials, in particular to an acrylic resin bone cement with sustained and high-efficiency release of antibiotics. [Background technique] [0002] Bone cement material is a self-setting biomedical material used to fill the bone cavity or gap between human bones and artificial joints. Its physical properties and cured appearance are similar to ordinary cement in construction, so it is commonly called bone cement. The main component of bone cement is methyl methacrylate resin polymer, which is widely used in artificial joint replacement surgery. During use, bone cement can firmly fix implants (such as artificial bone joints, etc.) The stability and firmness of the joint can avoid a series of problems caused by the loosening of the artificial joint, allow the patient to bear weight early after the operation, and greatly reduce the various complications caused by the patient's long-term bed rest. [000...

Claims

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Application Information

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IPC IPC(8): A61L27/16A61L27/54A61L27/02A61L27/18
CPCA61L27/025A61L27/16A61L27/18A61L27/54A61L2300/406A61L2300/602A61L2400/02C08L33/02C08L71/02
Inventor 李俊包乐乐
Owner SHANGHAI INSTITUTE OF TECHNOLOGY
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