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Microsphere preparation device and method thereof

A technology of microspheres and heating equipment, applied in the field of microspheres, can solve the problems of complex process, low output and long time, and achieve the effects of good safety, high output and controllable size of microspheres

Inactive Publication Date: 2018-12-14
CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The size of the microspheres prepared by the microfluidic method is controllable and uniform, but the output is very low and the process is complicated and unsuitable for industrial production. The solvent evaporation and microsphere solidification process takes a long time

Method used

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  • Microsphere preparation device and method thereof
  • Microsphere preparation device and method thereof
  • Microsphere preparation device and method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0067] The device for preparing microspheres provided in this example is as figure 1 shown, including:

[0068] Cylindrical barrel of polyethylene with a diameter of 11.5 mm and a length of 74 mm;

[0069] The moving slide rail 3 arranged inside the syringe, the moving slide rail 3 is a threaded piston rod, the stroke of the moving slide rail is 20cm, the pitch of the thread is 3mm, the moving slide rail can Form a closed cavity with the syringe, modify the volume of the cavity by changing the position of the moving slide rail, and form a gas pressure during the change of the cavity volume, so as to realize the suction of liquid from the outside into the syringe and squeeze the liquid out of the syringe The function is similar to the booster of the syringe;

[0070] The motor arranged at the tail of the moving slide rail 3, the motor is connected with the tail of the moving slide rail through a mechanical mechanism (coupling) and / or an electric circuit, and can push the movi...

Embodiment 2

[0081] The preparation of embodiment 2PLGA microspheres

[0082] Adopt the device described in embodiment 1 to prepare microspheres:

[0083] Before preparing the microspheres, the needle was inserted into the electric heating rod to heat, and the heating temperature of the electric heating rod was controlled by the temperature controller to reach 60°C. After the heating was completed, the needle and the sleeve were assembled to form a nozzle and installed on the gas distribution row.

[0084] The NMP (N-methylpyrrolidone) solution of PLGA with a mass concentration of 15% is packed into the syringe, the stepper motor controller is set to control the motor to rotate and the moving slide rail is moved, so that the speed of the moving slide rail advancing the solution is 0.2mL / min enters the needle of the nozzle through the air distribution exhaust, and the gas in the nitrogen cylinder enters the air flow channel of the nozzle through the air distribution exhaust at a speed of 1...

Embodiment 3

[0086] The preparation of embodiment 3 chitosan microspheres

[0087] Adopt the device described in embodiment 1 to prepare microspheres:

[0088] Before preparing microspheres, insert the needle into the electric heating rod for heating, and control the heating temperature of the electric heating rod to reach 60°C through the temperature controller. After the heating is completed, assemble the needle and the sleeve to form a nozzle and install it on the gas distribution row.

[0089] Put the acetic acid solution of chitosan with a mass concentration of 5% into the syringe, set the stepper motor controller to control the motor to rotate to move the mobile slide rail, so that the speed of the mobile slide rail to push the solution is 0.3mL / min through the gas distribution exhaust Entering the needle of the nozzle, by controlling the flow meter and the pressure reducing valve, the gas in the nitrogen cylinder enters the gas channel in the nozzle through the gas distribution exha...

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Abstract

The invention provides a microsphere preparation device. The microsphere preparation device comprises a syringe, the syringe is internally provided with a moving slide rail; the inlet of a nozzle is communicated with the outlet of the syringe, the nozzle comprises a needle, and an inlet of the needle is communicated with an outlet of the syringe; a sleeve is disposed outside the needle, the relative position of the needle and the sleeve is a concentric position, and a gap between the needle and the sleeve is an air flow passage; the outlet of a gas tank is communicated with the inlet of the gas flow passage; a receiving container is disposed under the nozzle, and the receiving container contains a curing agent solution; a heating device is disposed outside the needle, and the heating device is capable of heating the needle. The invention also provides a method for preparing microspheres. The invention provides the method for preparing the microspheres based on airflow shearing, and themethod provided by the invention can be used for preparing microspheres with a large scale, the size of the prepared microspheres is controllable, the spherical body uniformity is good, and the sphere density is controllable.

Description

technical field [0001] The invention relates to the technical field of microspheres, in particular to a microsphere preparation device and method. Background technique [0002] Because microspheres have good ability to control and release drug molecules, they have been widely used in the field of drug release for a long time. It is precisely because of the porous network structure of microspheres and the ability to release molecules such as drugs and growth factors that microspheres are gradually being used in regenerative medicine treatments. The diameter and distribution of spheres are important factors affecting the drug release of microspheres. Only microspheres of appropriate size can achieve the ideal drug release rate. If the sphere is too small, the encapsulation ability of the drug will be reduced, and at the same time, the drug will be released suddenly at the injection site. A sphere that is too large will make it difficult for the microspheres to be effectively...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01J13/04
CPCB01J13/046
Inventor 章培标王宇王宗良焦自学史新翠郭敏
Owner CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI
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