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Preparation method of SERS (surfaced enhanced Raman spectroscopy) substrate, SERS substrate and application of SERS substrate

A technology of substrate and silica, applied in the field of spectral analysis and detection, can solve the problems of high cost, unsuitable promotion, complicated operation, etc., and achieves the effects of good stability, abundant adsorption sites, and simple preparation process.

Inactive Publication Date: 2018-12-14
HEFEI INSTITUTES OF PHYSICAL SCIENCE - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] The technical problem to be solved by the present invention is that the existing method for detecting PCBs and antibiotics by using SERS is complex in operation, high in cost, unsuitable for wide promotion and suitable for

Method used

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  • Preparation method of SERS (surfaced enhanced Raman spectroscopy) substrate, SERS substrate and application of SERS substrate
  • Preparation method of SERS (surfaced enhanced Raman spectroscopy) substrate, SERS substrate and application of SERS substrate
  • Preparation method of SERS (surfaced enhanced Raman spectroscopy) substrate, SERS substrate and application of SERS substrate

Examples

Experimental program
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Embodiment 1

[0039] This embodiment discloses a preparation method for preparing a SERS substrate, and the specific steps are as follows:

[0040] (1) Preparation of silica nanoparticles and gold nanoparticles

[0041] The silica nanoparticles are Synthesized by method, the synthetic method refers to the literature Stober W, FinkA, Bohn E. Controlled growth of monodisperse silica spheres in the micron sizerange [J]. Journal of colloid and interface science, 1968, 26 (1): 62-69. In this example, silica nanoparticles with a size of 180 nm were obtained by adjusting the synthesis conditions.

[0042] The preparation process of the gold nanoparticles is as follows: a, dissolving the chloroauric acid powder in ultrapure water to obtain an aqueous solution of chloroauric acid, and keeping the aqueous solution at 4°C in the dark for at least 10 days; b, taking the ultrapure Put water in a conical flask, add NaOH solution therein, then add tetrakis hydroxymethyl phosphorus chloride under the co...

Embodiment 2

[0061] The preparation method of the SERS substrate in this example is basically the same as that in Example 1. Only by controlling the experimental conditions, the size of the obtained gold-shelled silica-coated nanoparticles is 520nm, and the size of the silica nanoparticles is 500nm.

[0062] The SERS substrate obtained in this example was used to detect the dimethyl sulfoxide solution of PCB-3, and the operation steps were the same as those in Example 1. The experimental results of this example are as Figure 4 and Figure 5 shown, where Figure 4 It is the SERS spectrogram of the PCB-3 of different concentrations in the present embodiment; Figure 5 for at 1446cm -1 , the relationship diagram of the SERS intensity of different concentrations of PCB-3 with the concentration.

[0063] It should be noted that other homologues of polychlorinated biphenyls can also be detected by using the SERS substrate, and the detection results are similar to those in Example 1 and Exam...

Embodiment 3

[0065] The preparation method of the SERS substrate in this example is basically the same as that in Example 1. Only by controlling the experimental conditions, the size of the obtained gold-shelled silica-coated nanoparticles is 310 nm, and the size of the silica nanoparticles is 300 nm.

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Abstract

The invention discloses a preparation method of an SERS (surfaced enhanced Raman spectroscopy) substrate. The method comprises the steps as follows: (1) gold shell layer nanoparticle sol coated with silicon dioxide is prepared with a step-by-step method; (2) the gold shell layer nanoparticle sol obtained in the step (1) is dropwise added to a microporous filter membrane, and the SERS substrate isobtained after natural airing, wherein the diameter of gold shell layer nanoparticles is larger than the pore diameter of micropores in a microporous filter membrane. The invention also discloses theSERS substrate prepared with the method and an application of the substrate in trace detection of an organic solution of PCB (polychlorinated biphenyls) and an antibiotic aqueous solution. The preparation method has the advantages as follows: the preparation method of the SERS substrate is simple, rapid, good in stability and capable of substantially improving the signal intensity of SERS detection.

Description

technical field [0001] The invention belongs to the field of spectral analysis and detection, and in particular relates to a preparation method of a SERS substrate, a SERS substrate and applications thereof. Background technique [0002] Polychlorinated biphenyls (PCB: Polychlorinated biphenyls) are persistent organic pollutants. The hydrogen atoms on biphenyl are replaced by multiple chlorine atoms to obtain polychlorinated biphenyls. In theory, there are 209 homologues. In actual production, a mixture of polychlorinated biphenyls is generally obtained. Due to its unique physical and chemical properties, PCBs can be used in many fields, such as insulating oil in capacitors and transformers, heat transfer oil in industrial production, lubricating oil in air compressors, etc. PCBs are artificially synthesized, and after being widely used, they enter the air, water, and soil through various channels, and accumulate in water and soil. However, PCBs are extremely difficult to ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/65
CPCG01N21/658
Inventor 黄青钟洁穆罕默德
Owner HEFEI INSTITUTES OF PHYSICAL SCIENCE - CHINESE ACAD OF SCI
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