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A sustained-release hypoglycemic pharmaceutical composition and its preparation method and application

A hypoglycemic and slow-release technology, which is applied in drug combination, drug delivery, and pharmaceutical formulations, can solve problems such as side effects and reduce patient compliance, and achieve improved hypoglycemic effect, improved medication compliance, and excellent hypoglycemic effect Effect

Active Publication Date: 2019-08-13
北京济全生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, since diabetes cannot be cured, once you get sick, you need to take medicine for a long time, and many medicines often need to be taken after each meal, resulting in the need to take medicine many times a day, which brings a lot of inconvenience to the patient's life and greatly reduces the patient's compliance. , the drug is released quickly after each dose, quickly reaches the maximum blood concentration, and may cause various side effects

Method used

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  • A sustained-release hypoglycemic pharmaceutical composition and its preparation method and application
  • A sustained-release hypoglycemic pharmaceutical composition and its preparation method and application
  • A sustained-release hypoglycemic pharmaceutical composition and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] Embodiment 1: A kind of slow-release tablet for lowering blood sugar

[0050] Rehmannia 5g, Yam 4g, Cornus 4g, Danpi 3g, Poria 3g, Alisma 3g, Lychee 2.5g, Atractylodes 2.5g, Ghost Arrow Feather 1.5g, Scrophulariaceae 3g, Epimedium 2.5g, Cistanche 2.5g , black aconite 0.5g, cinnamon 0.8g, gallinacea 2g, ephedra 0.5g, prepared according to the following method:

[0051] (1) material preparation: take each raw material according to the formula;

[0052] (2) Pulverization: Cistanche deserticola and gallinacea are pulverized through a 30-mesh sieve to obtain powder, which is set aside;

[0053] (3) Extraction: Add 80% of the total amount of 4 times the total amount of raw land, yam, cornus, paeonol, Poria cocos, Alisma, lychee core, herb, ghost arrow feather, Scrophulariaceae, epimedium, black aconite, cinnamon, and ephedra. % ethanol, soaked for 1.5h, then refluxed for 1.5h, filtered to obtain the filtrate for later use, fully used 3 times of 80% ethanol to reflux extract...

Embodiment 2

[0055] Embodiment 2: A kind of slow-release hypoglycemic capsule

[0056] Rehmannia 5g, Yam 4g, Cornus 4g, Danpi 3g, Poria 3g, Alisma 3g, Lychee 2.5g, Atractylodes 2.5g, Ghost Arrow Feather 1.5g, Scrophulariaceae 3g, Epimedium 2.5g, Cistanche 2.5g , black aconite 0.5g, cinnamon 0.8g, gallinacea 2g, ephedra 0.5g, prepared according to the following method:

[0057] (1) material preparation: take each raw material according to the formula;

[0058] (2) Pulverization: Cistanche deserticola and gallinacea are pulverized through a 30-mesh sieve to obtain powder, which is set aside;

[0059] (3) Extraction: Add 80% of the total amount of 4 times the total amount of raw land, yam, cornus, paeonol, Poria cocos, Alisma, lychee core, herb, ghost arrow feather, Scrophulariaceae, epimedium, black aconite, cinnamon, and ephedra. % ethanol, soaked for 1.5h, then refluxed for 1.5h, filtered to obtain the filtrate for later use, fully used 3 times of 80% ethanol to reflux extracted the filt...

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Abstract

The invention relates to a sustained-release blood-glucose-reduction medicinal composition as well as a preparation method and application thereof. The sustained-release blood-glucose-reduction medicinal composition comprisesis prepared from catalpol and a sustained-release carrier, and is preferably comprisesprepared from other active ingredients such as one or a combination of more of sulfonylureas, biguanides, analpha-glucosidase inhibitor, an euglycemic agent, glimepirideglinide medicine or traditional Chinese medicine composition. By adopting the sustained-release blood-glucose-reductionmedicinal composition, an effect for significantly reducing the blood glucose, triglyceride, cholesterol and glycosylated hemoglobin of high-blood-glucose mice or rat can be achieved, and the effect for preventing and treating type-II diabetes can be achieved.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, and in particular relates to a slow-release and hypoglycemic pharmaceutical composition, a preparation method and application thereof. Background technique [0002] With the continuous improvement of people's living standards, hyperglycemia has become one of the main metabolic diseases that seriously plague people's health. Blood sugar is the abbreviation of glucose in the blood. The human body maintains a relatively constant blood sugar level by regulating the source of blood sugar and the balance of metabolism. The blood sugar of adult venous plasma is <6.4mmol / L. The acquisition of blood glucose homeostasis depends on the secretion of insulin, the uptake of blood glucose by peripheral tissues and liver, and the production of sugar by the liver. When the metabolic disorder is caused by insufficient insulin synthesis in the pancreas or decreased insulin sensitivity in peripheral tis...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/22A61K9/52A61K47/38A61K47/36A61K36/8945A61K31/7048A61K45/06A61P3/10A61K35/57A61K31/155
CPCA61K9/0053A61K9/1652A61K9/205A61K9/2054A61K9/2077A61K9/4808A61K31/155A61K31/7048A61K35/57A61K36/076A61K36/17A61K36/284A61K36/296A61K36/37A61K36/40A61K36/54A61K36/64A61K36/65A61K36/71A61K36/714A61K36/77A61K36/808A61K36/884A61K36/8945A61K45/06A61K2236/333A61K2236/39A61K2236/51A61P3/10A61K2300/00
Inventor 王玮
Owner 北京济全生物科技有限公司
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