Granulation promoting ointment containing components of conjugated linoleic acid, organic zinc and peptide, and preparation method of granulation promoting ointment

A technology of conjugated linoleic acid and Shengji ointment, which is applied in the direction of medical preparations containing active ingredients, inorganic active ingredients, aluminum/calcium/magnesium active ingredients, etc. Complex composition, narrow treatment range and other issues, to achieve the effect of improving disease resistance and antioxidant capacity, no adverse reactions, and reducing inflammatory reactions

Inactive Publication Date: 2019-01-01
TIANJIN HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Most of the existing Shengji ointments are complex in composition, with unclear material basis for drug efficacy, unstable quality, and insignificant curative effect, and can only treat a certain type or similar types of skin lesions, and the treatment range is narrow

Method used

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  • Granulation promoting ointment containing components of conjugated linoleic acid, organic zinc and peptide, and preparation method of granulation promoting ointment

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Accurately weigh the following raw materials: 10 parts of raw blood, 23 parts of raw tortoise shell, 11 parts of angelica, 25 parts of raw land, 28 parts of raw gypsum, 33 parts of calamine, 18 parts of elephant skin, 80 parts of yellow wax, and 480 parts of sesame oil.

[0033] S1. Scald elephant skin with talcum powder, powder it, pass through a 80-mesh sieve, crush raw gypsum and calamine, and pass through an 80-mesh sieve; take 50% vegetable oil and heat it to 230°C, add raw blood, and fry for 12 minutes until Porridge, filter to remove residue;

[0034] S2. Add the remaining vegetable oil, wait until the oil temperature drops to 200°C, put in raw tortoise shells and fry for 22 minutes until it becomes chestnut skin color, filter to remove residue;

[0035] S3. Put it into raw ground and fry at 200°C for 6 minutes until thoroughly fried, then remove; put in angelica and fry for 3 minutes until thoroughly fried, filter to remove slag;

[0036] S4. Put in raw gypsum ...

Embodiment 2

[0039] Accurately weigh the following raw materials: 14 parts of raw blood, 20 parts of raw tortoise shell, 15 parts of angelica, 24 parts of raw land, 28 parts of raw gypsum, 28 parts of calamine, 16 parts of elephant skin, 95 parts of yellow wax, and 550 parts of sesame oil.

[0040] S1. Scald elephant skin with talcum powder, powder it, pass through a 120-mesh sieve, pulverize raw gypsum and calamine, and pass through a 120-mesh sieve; take 50% vegetable oil and heat it to 260°C, add raw blood, and fry for 15 minutes until Porridge, filter to remove residue;

[0041]S2. Add the remaining vegetable oil, wait until the oil temperature drops to 180°C, put in the raw tortoise shell and fry for 20 minutes, until it becomes the color of chestnut skin, filter to remove the residue;

[0042] S3. Put it into raw ground and fry at 210°C for 3 minutes until thoroughly fried, then remove; put in angelica and fry for 1 minute until thoroughly fried, filter to remove slag;

[0043] S4. ...

Embodiment 3

[0046] Accurately weigh the following raw materials: 12 parts of raw blood, 30 parts of raw tortoise shell, 10 parts of angelica, 26 parts of raw land, 31 parts of raw gypsum, 30 parts of calamine, 15 parts of elephant skin, 100 parts of yellow wax, and 450 parts of sesame oil.

[0047] S1. Scald elephant skin with talcum powder, powder it, pass through a 100-mesh sieve, crush raw gypsum and calamine, and pass through a 100-mesh sieve; take 50% vegetable oil and heat it to 250°C, add raw blood, and fry for 13 minutes until Porridge, filter to remove residue;

[0048] S2. Add the remaining vegetable oil, wait until the oil temperature drops to 190°C, put in raw tortoise shells and fry for 18 minutes until it becomes chestnut skin color, filter to remove residue;

[0049] S3. Put it in raw ground and fry at 180°C for 4 minutes until thoroughly fried, then remove; put in angelica and fry for 2 minutes until thoroughly fried, filter to remove slag;

[0050] S4. Put in raw gypsum ...

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Abstract

The invention provides granulation promoting ointment containing components of conjugated linoleic acid, organic zinc and peptide and further provides a preparation method of the granulation promotingointment containing the components of the conjugated linoleic acid, the organic zinc and the peptide. The content of the conjugated linoleic acid is 3.6-4.2%, the content of the peptide is 0.3-0.5%,and the content of Zn<2+> in an n-hexane extraction layer is 1.5-1.9%. The granulation promoting ointment and the preparation method have the beneficial effect that by conducting treatment with different temperatures and times on raw materials in sequence, the components of the conjugated linoleic acid, the organic zinc and the peptide are generated in the finished granulation promoting ointment,wherein the peptide has the effects of accelerating tissue repair and promoting wound healing, the conjugated linoleic acid has the effects of promoting cell division, having growth promotion factors,resisting oxidation, improving the immunoreaction of somatic cells and reducing inflammatory reactions and is capable of promoting wound repair, and the organic zinc has the advantages of having highbiological value, enhancing immunity and improving disease and oxidation resistant capacity; and for chronic refractory wounds of traumatic skin defect, refractory ulceration, bedsores, diabetic footand the like, the granulation promoting ointment is good in efficacy, convenient to use and free of adverse reactions and produces an instant effect.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine preparations, and in particular relates to a Shengji ointment containing conjugated linoleic acid, organic zinc and peptide components and a preparation method thereof. Background technique [0002] Refractory wounds mainly refer to large-area skin and soft tissue defects or chronic wounds caused by severe trauma, which are characterized by large wound area, deep depth, chronic wound extracellular matrix remodeling, inhibited re-epithelialization, and long-term inflammatory response. It is a frequently encountered problem in surgery and orthopedic surgery. For refractory wounds caused by various skin diseases and surgical infections such as burns and scalds, it is necessary to clean up and apply external medicines. The quality of external medicines determines the degree of wound healing. [0003] The existing clinical medicines for surgical infection mainly include antibiotic...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/804A61K9/06A61P17/02A61P3/10A61K35/586A61K35/36A61K33/30A61K33/06
CPCA61K9/0014A61K9/06A61K33/06A61K33/30A61K35/36A61K35/586A61K36/185A61K36/232A61K36/804A61K47/44A61P3/10A61P17/02A61K2300/00
Inventor 周永梅房德敏冯鑫戴滨王巨存邢国胜杨阳徐卫国马信龙
Owner TIANJIN HOSPITAL
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