Composite artificial cornea and preparation method thereof

A technology of artificial cornea and cornea, applied in the field of compound artificial cornea and its preparation, can solve the problems of lack of good compatibility, inflammation, corneal shedding, etc., and achieve the effect of simple structure, controllable parameters and uniform structure

Active Publication Date: 2019-01-08
广州锐澄医疗技术有限公司
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Problems solved by technology

Among them, the skirt stent is the part directly in contact with the implant bed, which plays the role of fusion with human eye tissue cells, but most heter

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  • Composite artificial cornea and preparation method thereof
  • Composite artificial cornea and preparation method thereof
  • Composite artificial cornea and preparation method thereof

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[0030] The embodiments of the present invention will be described in detail below. It should be emphasized that the following description is only exemplary, and is not intended to limit the scope of the present invention and its application.

[0031] See Figure 1a to Figure 4 In one embodiment, a composite artificial cornea 11 includes a central optical lens column 12 made of polyhydroxyethyl methacrylate (PHEMA), a corneal skirt structure made of acellular matrix hydrogel 14, And a middle sandwich grid bracket 13 connecting the central optical lens column 12 and the corneal skirt structure 14, wherein the corneal skirt structure 14 is provided with a nerve cell scaffold layer 15 to which cells have grown and the corneal stroma Cell scaffold layer 16 is a two-layer scaffold.

[0032] In a preferred embodiment, the intermediate sandwich grid support 13 is formed by electrostatic direct writing and printing, for example, by melting and printing by an electrostatic direct writing bi...

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Abstract

The invention discloses a composite artificial cornea and a preparation method thereof. The composite artificial cornea comprises a central optical pillar prepared from polyhydroxyethyl methacrylate (PHEMA), a corneal skirt structure prepared from an acellular stromal hydrogel, and an intermediate sandwich grid scaffold connecting the central optical pillar and the corneal skirt structure, whereinthe corneal skirt structure is provided with a nerve cell scaffold layer to which cells are adhered and a corneal stromal cell scaffold layer. The composite artificial cornea is simple in structure,good in biocompatibility, easy to process, can well simulate the environment of cornea in vivo, and is favorable for transplantation.

Description

technical field [0001] The invention relates to a composite artificial cornea and a preparation method thereof. Background technique [0002] Corneal disease is the second leading cause of blindness after cataracts. Corneal clouding is one of the leading causes of bilateral blindness, affecting 7 million people worldwide. Of these, 2.85 million had reduced or no sensation due to corneal nerve dysfunction or degeneration. Corneal transplantation is the only way to restore sight to blind patients. However, traditional corneal transplantation has two major disadvantages. One is that the source of corneal donors is difficult, and the other is that the success rate of the operation is extremely low for corneal recipients with many new blood vessels. , such as corneas with severe chemical and thermal burns, corneas with multiple corneal transplant failures, corneas with severe dry eye, petechiae, etc. The emergence of artificial corneas can solve these two problems, that is, the...

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Application Information

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IPC IPC(8): A61F2/14A61L27/16A61L27/18A61L27/36A61L27/38A61L27/50
CPCA61F2/142A61F2240/004A61L27/16A61L27/18A61L27/3633A61L27/3804A61L27/383A61L27/3891A61L27/50A61L2430/16C08L33/14C08L67/04
Inventor 弥胜利孙伟王杰琼
Owner 广州锐澄医疗技术有限公司
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