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A kind of oral antithrombotic drug and its application

A technology for drugs and pharmaceutical excipients, which can be used in drug combinations, pharmaceutical formulations, blood diseases, etc., and can solve problems such as unclear research and complex thrombosis mechanisms.

Active Publication Date: 2021-01-26
HEILONGJIANG ZHONGGUI PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the complex mechanism of thrombus formation, its exact anticoagulant and antithrombotic mechanism has not yet been studied clearly.

Method used

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  • A kind of oral antithrombotic drug and its application
  • A kind of oral antithrombotic drug and its application
  • A kind of oral antithrombotic drug and its application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Embodiment 1 antithrombotic oral tablet

[0039] Prescription: 120 mg of captopril, 60 mg of compound (X1), 1200 mg of microcrystalline cellulose, 1200 mg of lactose, 120 mg of low-substituted hydroxypropyl cellulose, 24 mg of corn starch, 24 mg of magnesium stearate and water.

[0040]preparation:

[0041] (1) Take the prescribed amount of captopril, compound (X1), microcrystalline cellulose, lactose, low-substituted hydroxypropyl cellulose, cornstarch and magnesium stearate and pulverize them through an 80-mesh sieve;

[0042] (2) Captopril, compound (X1), microcrystalline cellulose, lactose, and low-substituted hypromellose powder are mixed;

[0043] (3) Prepare corn starch powder into 10% starch slurry, mix it with the powder mixture obtained in step (2) to prepare soft material, pass through a 20-mesh sieve for granulation, dry at 60°C, pass through a 18-mesh sieve for granulation, and harden Magnesium fatty acid, mixed evenly, compressed into tablets, each table...

Embodiment 2

[0044] Embodiment 2 antithrombotic oral tablet

[0045] Prescription: 120 mg of captopril, 40 mg of compound (X1), 1200 mg of microcrystalline cellulose, 1200 mg of lactose, 120 mg of low-substituted hydroxypropyl cellulose, 24 mg of corn starch, 24 mg of magnesium stearate and water.

[0046] Preparation: (1) Take the prescribed amount of captopril, compound (X1), microcrystalline cellulose, lactose, low-substituted hydroxypropyl cellulose, corn starch and magnesium stearate, and grind them through an 80-mesh sieve;

[0047] (2) Captopril, compound (X1), microcrystalline cellulose, lactose, and low-substituted hypromellose powder are mixed;

[0048] (3) Prepare corn starch powder into 10% starch slurry, mix it with the powder mixture obtained in step (2) to prepare soft materials, pass through a 20-mesh sieve for granulation, dry at 50°C, pass through a 18-mesh sieve for granulation, and harden Magnesium fatty acid, mixed evenly, compressed into tablets, each tablet contains...

Embodiment 3

[0049] Embodiment 3 antithrombotic oral tablet

[0050] Prescription: 120 mg of captopril, 60 mg of compound (X2), 1200 mg of microcrystalline cellulose, 1200 mg of lactose, 120 mg of low-substituted hydroxypropyl cellulose, 24 mg of corn starch, 24 mg of magnesium stearate and water.

[0051] preparation:

[0052] (1) Take the prescribed amount of captopril, compound (X2), microcrystalline cellulose, lactose, low-substituted hydroxypropyl cellulose, cornstarch and magnesium stearate and pulverize them through an 80-mesh sieve;

[0053] (2) Captopril, compound (X2), microcrystalline cellulose, lactose, and low-substituted hypromellose powder are mixed;

[0054] (3) Prepare corn starch powder into 10% starch slurry, mix it with the powder mixture obtained in step (2) to prepare soft material, pass through a 20-mesh sieve for granulation, dry at 60°C, pass through a 18-mesh sieve for granulation, and harden Magnesium fatty acid, mixed evenly, compressed into tablets, each tabl...

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Abstract

The invention belongs to the field of chemical drugs, in particular to an oral antithrombotic drug and uses thereof. The oral antithrombotic drug is prepared from an angiotensin converting enzyme inhibitor, a compound containing pyridine ring and pharmaceutical adjuvant. In vivo and in vitro studies have shown that the oral antithrombotic agent has good therapeutic effect on thrombosis.

Description

technical field [0001] The invention belongs to the field of chemical drugs, and in particular relates to an oral antithrombotic drug and its application. Background technique [0002] A thrombus is a small lump of blood that forms on the surface of a broken or repaired inside of a blood vessel. Damaged blood vessels, slowed blood flow, elevated blood lipids, and abnormal platelet aggregation are important causes of thrombus formation in the body. Arterial thrombosis is mostly formed on the basis of atherosclerosis. Typical thrombotic diseases include cerebral thrombosis, myocardial infarction, etc., which are mostly diseases that seriously affect the life safety of patients, and are prone to acute attacks, which can easily lead to death or disability. [0003] Thrombotic diseases include two pathological processes of thrombosis and thromboembolism. The former refers to that under certain conditions, blood components form emboli in blood vessels, causing partial or comple...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/4409A61K31/401A61K9/20A61P7/02A61P9/00A61P9/10
CPCA61K9/20A61K31/401A61K31/4409A61P7/02A61P9/00A61P9/10A61K2300/00
Inventor 张树乘宫玉晶欧世宏张玉清张晶宋安祥
Owner HEILONGJIANG ZHONGGUI PHARMA
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