Method for preparing curcumin from vanillin and related analogues

A technology of analogs and vanillin, which is applied in the direction of microorganism-based methods, biochemical equipment and methods, and the preparation of organic compounds, can solve the problems of high energy consumption, single substrate price, and high pollution in chemical synthesis, and achieve improved The effect of product utilization efficiency, saving reaction time, and simplifying the operation process

Pending Publication Date: 2019-01-11
NORTHEAST DIANLI UNIVERSITY
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Problems solved by technology

The microbial transformation method can solve the inconvenience caused by the limitation of plant species in the traditional plant extraction method, as well as the high energy consumption and high pollution problems of the chemical synthesis method, and provides a new strategy and technical means for the production of curcumin. Therefore, The preparation of curcumin by microbial transformation is a fast, green, effective and safe way. However, the current microbial transformation method uses ferulic acid or coumaric acid as the substrate to prepare curcumin. The substrate is relatively single and expensive, which limits its use. Therefore, there is an urgent need to develop a method for the simple synthesis of curcumin using cheaper bulk raw materials

Method used

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  • Method for preparing curcumin from vanillin and related analogues
  • Method for preparing curcumin from vanillin and related analogues
  • Method for preparing curcumin from vanillin and related analogues

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0050] 1. Chemical reverse synthesis of acetylferulic acid from vanillin as a substrate for biological fermentation:

[0051] (1) Combine vanillin and K 2 CO 3 Dry at about 50°C to constant weight.

[0052] (2) Add 1g of dry vanillin and K 2 CO 3 1.27g was stirred and mixed evenly, after stirring evenly, 6.7 mL of acetic anhydride was added into the flask, and the oil bath was 160°C, and reacted for 8 hours.

[0053] (3) After the reaction, pour the brown-yellow solution produced in step (2) into a beaker filled with about 30 g of crushed ice while it is still hot, to terminate the reaction, and then separate into an oil layer and a water layer.

[0054] (4) Freeze the beaker overnight to separate the light yellow powdery substance, filter the product with suction, wash the filter cake until the washing liquid has no sour taste; dry the washed product at 50°C to obtain 1.35 g of the dried product, the product is mainly The ingredient is acetyl ferulic acid.

[0055] 2. P...

Embodiment 2

[0064] Other steps are with embodiment 1, but K in step 1 2 CO 3 Change to Na 2 CO 3 , the added amount is 0.98g.

Embodiment 3

[0066] Other steps are with embodiment 1, but K in step 1 2 CO 3 Change to CH 3 COONa, the added amount is 0.76g.

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Abstract

The invention relates to a method for preparing curcumin by using vanillin and related analogues, belonging to the technical field of combining chemical industry and bioengineering. The method comprises the following steps: preparing biological fermentation substrate by chemical synthesis of vanillin and its analogues, and carrying out biological fermentation on the biological fermentation substrate to prepare curcumin. The invention combines the chemical synthesis and the biological conversion path and utilizes the cheap raw materials to prepare curcumin, which not only realizes the rapid andsafe synthesis of curcumin, but also has very important engineering significance.

Description

technical field [0001] The invention belongs to the combined technical field of chemical engineering and biological engineering. Background technique [0002] Curcumin, commonly known as curcumin, is a rare natural diketone pigment in plants and is considered to be one of the most valuable edible natural pigments. In nature, it mostly exists in the roots or rhizomes of Zingiberaceae and Araceae plants, and is the main biologically active component. Due to the different substituents of the side chains of the benzene ring, curcumin exists in various forms in nature. As a safe and non-toxic pigment, curcumin is widely used in the coloring process and pH calibration in food production. In recent years, the pharmacological effects of curcumin in reducing blood fat, anti-tumor, anti-hepatic fibrosis, and anti-atherosclerosis have been gradually discovered and confirmed. At present, the main methods of preparing curcumin are plant extraction, chemical synthesis and microbial tra...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12P7/26C07C69/07C07C67/08C12R1/19
CPCC12P7/26C07C67/08C07C69/07
Inventor 于大禹孙贺铭王磊乔楠
Owner NORTHEAST DIANLI UNIVERSITY
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