Electrochemical sensor constructed based on nitrogen-sulfur co-doped graphene-loaded triangular core-shell nanocomposite, and application thereof for detecting quercetin

A technology of core-shell nanomaterials and nanocomposites, applied in the direction of material electrochemical variables, scientific instruments, analytical materials, etc., can solve the problems of not being widely used, poor stability, easy agglomeration, etc., to improve stability and catalytic performance, The effect of increasing the contact interface and sufficient activity

Active Publication Date: 2019-01-11
HONGHE COLLEGE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the particle size of nanoparticles is too small, they are easy to agglomerate, and their stability is poor, which is limited in practical applications and cannot be widely used.

Method used

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  • Electrochemical sensor constructed based on nitrogen-sulfur co-doped graphene-loaded triangular core-shell nanocomposite, and application thereof for detecting quercetin
  • Electrochemical sensor constructed based on nitrogen-sulfur co-doped graphene-loaded triangular core-shell nanocomposite, and application thereof for detecting quercetin
  • Electrochemical sensor constructed based on nitrogen-sulfur co-doped graphene-loaded triangular core-shell nanocomposite, and application thereof for detecting quercetin

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] The preparation of embodiment 1 nitrogen-sulfur co-doped graphene

[0048] Take 10mL graphene oxide (0.5mg / mL), weigh L-cysteine ​​according to the mass ratio of graphene oxide and L-cysteine ​​as 1:5, mix the two with ultrasound for half an hour, and disperse evenly Put it into an autoclave and heat up to 180°C, and react for 8 hours. After cooling to room temperature, pour the solution into a centrifuge tube, centrifuge at 30,000r / min for 5 minutes, remove the supernatant, dilute with water and continue centrifuging until the excess L-cysteine ​​is eluted. Save the cleaned nitrogen-sulfur co-doped graphene for future use.

Embodiment 2

[0049] The synthesis of embodiment 2 silver triangular nanoparticles

[0050] 1. Synthesis of silver nanoseed crystals

[0051] At constant temperature (25°C), take 20mL, 0.25mmol / L AgNO 3Mix solution with 0.25mmol / L trisodium citrate, stir vigorously; then add 0.60mL freshly prepared and iced 10mmol / L sodium borohydride solution to the mixture at one time, stir rapidly for 30s, the solution turns yellowish brown , to obtain Ag seeds, and the reaction system was kept away from light for further use. The control seed aging time is 12h.

[0052] 2. Preparation of silver triangular nanoparticles

[0053] Add 0.50 mL, 0.1mol / L ascorbic acid (Vc) solution to 10mL, 80mmol / L cetyltrimethylammonium bromide (CTAB) solution, shake the mixture; then add 0.25mL, 10mmol / L L AgNO 3 solution, mix evenly; then add 0.20mL aged seed solution, shake the mixed solution; finally, add 0.10mL, 1mol / L NaOH solution to the above system, mix well, and let stand for about 10min. Store the reacti...

Embodiment 3

[0055] Example 3 Preparation of Ag@Au triangular core-shell nanomaterials

[0056] Take 2000 μL of the above-prepared silver triangle nanoparticles and put them into a beaker with 3000 μL of ultrapure water, add 13uL, 117.6mmol / L HAuCl 4 Solution, stirred and mixed evenly, cooled in an ice bath for about 10 minutes, slowly added dropwise 1000 μL, 0.1mol / L ascorbic acid, stirred vigorously during the dropping process, and kept in an ice bath for 40 minutes to obtain the Ag@Au triangle Core-shell nanomaterials.

[0057] figure 2 It is the ultraviolet spectrogram of silver nanoparticles, silver triangles and Ag@Au nanoparticles. Silver nanoparticles (curve a) have an obvious characteristic absorption peak at around 400nm, indicating that silver seeds have been successfully synthesized; and Ag triangular nanoparticles (Curve b) has two characteristic absorption peaks at 445nm and 570nm respectively; as Au is coated on the surface of Ag triangular nanoparticles, the characteri...

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Abstract

The invention provides an electrochemical sensor constructed based on a nitrogen-sulfur co-doped graphene-loaded silver-gold triangular core-shell nanocomposite. The electrochemical sensor is preparedfrom the following steps: loading a prepared silver-gold triangular core-shell nano material on a nitrogen-sulfur co-doped graphene surface, modifying a glassy carbon electrode with the composite toobtain the electrochemical sensor for detecting quercetin in a product. The beneficial effect is that the electrochemical sensor is used for detecting the quercetin, the detection current of the quercetin can be greatly improved, the sensitivity is high, the response speed is high, the reproducibility is good, and the anti-interference performance on an ascorbic acid in a sample to be tested is good.

Description

technical field [0001] The invention relates to an electrochemical sensor constructed on the basis of a nitrogen-sulfur co-doped graphene loaded triangular core-shell nanocomposite material, and the electrochemical sensor constructed by the composite material can be used for the detection of quercetin. Background technique [0002] Quercetin is a flavonoid compound widely present in the flowers, leaves, and fruits of various plants. It is one of the substances with the strongest antioxidant capacity in nature. It has anti-inflammatory, anti-tumor, anti-allergic and other pharmacological properties. effect. Since both ascorbic acid and quercetin are widely present in various plants, the selection of an electrochemical sensor for the detection of quercetin not only requires high selectivity and sensitivity, but also must be able to resist the interference of ascorbic acid on the detection of quercetin. [0003] The construction of electrochemical sensors based on nanocomposit...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N27/327G01N27/30
CPCG01N27/308G01N27/3278
Inventor 陈显兰杨光明张国伟刘卫石玲苟高章冯绍平
Owner HONGHE COLLEGE
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