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Preparation method for medical ozonized oil

A technology of ozonated oil and ozonation, which is applied in the fields of drug synthesis and organic synthesis, can solve the problems of inaccurate detection of active components of ozonated oil, poor stability of peroxides, easy escape of gas components, etc., and achieve low manufacturing cost , high antibacterial activity, ensure the effect of judgment

Active Publication Date: 2019-01-18
陕西福科原力健康科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Toxic organic solvents are used in this method, and there are relatively large residues in the ozonated oil. Although it has little effect when used in the field of pesticides, there are potential risks in the use of ozonated oil for medical use.
In the bubbling reaction, a large flow of gas is introduced, which not only provides ozone raw materials, but also plays a stirring role to a certain extent. However, as the reaction progresses, the viscosity of the system gradually increases, and the uniform stirring is achieved simply by bubbling. purpose is very difficult
Potassium iodide solution monitoring reaction is carried out by oxidation reaction, and cannot accurately detect active components in ozonated oil
O dissolved in ozonated oil 2 , O 3 and other gas components are very easy to escape; and the stability of some peroxides is relatively poor, so the ozone consumption in the reaction process as the specification of ozonated oil has obvious limitations in the quality control of ozonated oil

Method used

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  • Preparation method for medical ozonized oil
  • Preparation method for medical ozonized oil
  • Preparation method for medical ozonized oil

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Add 50mL of olive oil to a 100mL three-necked flask equipped with a stirring (magnetic force) and temperature control device, set the reaction temperature to 5°C, and after the reaction system reaches the set temperature and stabilizes, turn on the air source type ozone generator and set The fixed power is 100W, the ozone output is 10g / h, and the ozone content is 150ppm (the other components introduced are nitrogen, oxygen and a small amount of carbon dioxide in the air). Below the surface, above the stirring magnet. During the process of feeding ozone into the olive oil, the stirring speed was set at 1500 RPM, and the reaction product was detected every 30 min.

[0031] Prepare the test sample and set the test parameters: take 100 mg of the ozonation reaction product and dissolve it in 0.4 mL of deuterated chloroform (CDCl 3 ), transferred to a 5mm standard NMR tube, and Bruker 400MHz measured the carbon resonance signal of the sample ( 13 CNMR), the probe temperatur...

Embodiment 2

[0035] The reaction process is similar to Example 1, and the difference is that: a 10L reactor equipped with a mechanical stirring device is used, 5L soybean oil is added in the reactor, the controlled reaction temperature is 15°C, the power of the air source type ozone generator is 1000W, and the ozone The output is 150g / h, and the stirring speed is set at 2500RPM. 13 CNMR detection reaction time is 72h.

Embodiment 3

[0037] The reaction process is similar to Example 1, the difference is: adopt the 100L reactor of configuration mechanical stirrer, add 60L sunflower oil in the reactor, control reaction temperature to be 35 ℃, air source type ozone generator (equipped with intake air The power of the drying system) is 3000W, the ozone output is 400g / h, and the stirring speed is set at 1000RPM. 13 CNMR detection reaction time is 70h.

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Abstract

The invention discloses a preparation method for medical ozonized oil. By taking vegetable oil as an initial raw material, ozone is introduced by an ozone generator continuously to carry out an ozonizing reaction to obtain the ozonized oil. The reactant meets the demand on the medical ozonized oil. The method is easily available in raw material, relatively low in cost, simple to operate, green andenvironment-friendly and suitable for scaled production.

Description

technical field [0001] The invention belongs to the fields of medicine synthesis and organic synthesis, and relates to a preparation method of medical ozonated oil. Background technique [0002] Ozone is an allotrope of oxygen and has strong oxidizing properties. As a non-polluting and non-toxic bactericidal substance, its role has been widely recognized. Studies have found that after ozonation of vegetable oils rich in unsaturated fatty acids, oxidative substances such as hydrogen peroxide, hydroxyl-hydroperoxides, aldehydes, dimer peroxides and polyperoxides can be produced, These substances have a significant broad-spectrum antibacterial effect on microorganisms, and have been used in the control of crop diseases and insect pests for a long time. Modern pharmacological studies have shown that medical ozonated oil has strong oxidative properties and broad-spectrum antibacterial activity, and is highly biocompatible to fibers and epithelial cells. The application of medic...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C11C3/00A61K33/00A61P31/04C01B13/10
CPCA61K33/00A61P31/04C01B13/10C11C3/006
Inventor 李侃社陈福欣刘静白巧秀杨倩倩杨雅文段飞杨龚频
Owner 陕西福科原力健康科技有限公司
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