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Method for preparing biomimetic blood vessel stent by composite technology

A technology of bionic blood vessels and vascular stents, which is applied in the direction of blood vessels and human tubular structure devices, can solve the problems of impossible and difficult preparation of bionic blood vessel structures, and achieve the effect of simple preparation structure, high structural strength and clear structure

Active Publication Date: 2019-01-25
SHANGHAI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

It can be seen from this that different vascular layers have different cell adhesions, and the three-layer vascular stents prepared above basically cannot be inoculated with cells in the middle layer, making it difficult to prepare bionic vascular structures

Method used

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  • Method for preparing biomimetic blood vessel stent by composite technology
  • Method for preparing biomimetic blood vessel stent by composite technology
  • Method for preparing biomimetic blood vessel stent by composite technology

Examples

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Effect test

Embodiment 1

[0032] In this example, see Figure 1-Figure 3 As shown, a method for preparing a bionic vascular stent by a composite process, adopts coaxial electrospinning and coaxial hollow fiber technology to prepare a composite three-layer artificial blood vessel; including the following steps:

[0033] a. If figure 1 As shown, first prepare a rotating shaft, which is used to shape the model of the vascular structure, as a receiving device; it is also possible to control the diameter of the prepared blood vessel by selecting different rotating shafts, such as figure 1 middle(1);

[0034] b. Wrap a layer of 0.2mm thin copper wire on the rotating shaft, and stick the two sections with tape to prevent loosening; it will help to remove the vascular stent later, such as figure 1 in (2);

[0035] c. Prepare the inner layer of blood vessels: Weigh 0.8g of PLA and place it in a beaker, then measure 8ml of dichloromethane and 2ml of dimethylformamide, add them all to the beaker, and wrap them...

Embodiment 2

[0041] This embodiment is basically the same as Embodiment 1, especially in that:

[0042] In this embodiment, a method for preparing a biomimetic vascular stent by a composite process is prepared by coaxial electrospinning of a mixed material to prepare a composite blood vessel of the inner layer, including the following steps:

[0043] a. This step is the same as in Embodiment 1;

[0044] b. This step is the same as in Embodiment 1;

[0045] c. Preparation of the inner layer structure of the blood vessel: Prepared by coaxial electrospun mixed material, that is, weighed 0.8g of PLA and placed it in a beaker, then weighed 8ml of dichloromethane and 2ml of dimethylformamide, Add all of it into the beaker, cover the beaker with tinfoil, let it stand for two hours to let the PLA dissolve completely, then stir it with a glass rod to make the PLA completely dissolve, add it to the syringe, install it on the syringe pump, and supply to the core layer of the coaxial electrospinning...

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Abstract

The invention discloses a method for preparing a biomimetic blood vessel stent by composite technology, a blood vessel stent with three-layer structure is prepared by adopting coaxial electrospinningtechnology and coaxial extrusion hollow fiber technology in the field of biological manufacture, and each layer of the blood vessel scaffold can be inoculated with different types of cells between thethree layers of the blood vessel stent, so that the blood vessel stent has a true biomimetic human blood vessel structure; the inner and outer layers can be loaded with drugs, and the middle layer can provide oxygen, nutrients and exclude metabolites for cells. It is helpful to the growth of blood vessel and shortens the period of blood vessel growth, so it has a broad prospect of clinical application.

Description

technical field [0001] The invention relates to a method for preparing a bionic vascular stent, in particular to a method for preparing a bionic three-layer composite vascular stent, which is applied in the technical field of biomanufacturing. Background technique [0002] With the development in recent years, cardiovascular disease has become one of the major diseases that endanger people's life and health. Such as coronary heart disease caused by arteriosclerosis, arterial occlusive disease, blood vessel damage and so on. At present, the main method for treating vascular diseases is blood vessel transplantation. Generally, the best source of blood vessels is autologous blood vessel transplantation, but the source of autologous blood vessels is limited. The main way to solve this difficult problem is to use artificial blood vessels as substitutes, so a large number of artificial blood vessels are used as transplant substitutes in clinical applications. [0003] Due to the...

Claims

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Application Information

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IPC IPC(8): A61F2/06
CPCA61F2/062
Inventor 胡庆夕刘随红张海光孙程艳李钰苏彩平
Owner SHANGHAI UNIV
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