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Novel calcium magnesium silicate and silk fibroin composite porous scaffold and preparation method thereof

A technology of silk fibroin and magnesium silicate, applied in the fields of medical science, prosthesis, tissue regeneration, etc., to achieve the effect of low production cost, simple process and short time

Pending Publication Date: 2019-01-29
林泽枫
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is still no report on the use of calcium magnesium silicate bioactive ceramic materials to composite silk fibroin.

Method used

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  • Novel calcium magnesium silicate and silk fibroin composite porous scaffold and preparation method thereof
  • Novel calcium magnesium silicate and silk fibroin composite porous scaffold and preparation method thereof
  • Novel calcium magnesium silicate and silk fibroin composite porous scaffold and preparation method thereof

Examples

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Effect test

Embodiment 1

[0028] A novel calcium magnesium silicate and silk fibroin composite porous scaffold and a preparation method thereof are provided. Add magnesian feldspar powder into n-butanol at a mass volume ratio of 2g:100mL, place it in a ball mill jar for mechanical ball milling at a speed of 200rpm for 2h; then ultrasonically disperse the milled slurry with an ultrasonic power of 35W and a frequency of 40kHz; after ultrasonication for 10min, at a stirring speed of 200rpm, add the above-mentioned dispersion solution dropwise to the silk fibroin solution with a mass fraction of 10% at a volume ratio of 4:2 to control the mass ratio of feldspar to silk fibroin The ratio is 10:100; the mixed suspension is placed in a refrigerator at -20°C for 10 hours, then thawed at room temperature for 6 hours to obtain a white silk fibroin scaffold, and the scaffold is cleaned with deionized water and n-butanol. The scaffold is freeze-dried to obtain a composite porous bone tissue engineering scaffold. ...

Embodiment 2

[0031] A novel calcium magnesium silicate and silk fibroin composite porous scaffold and a preparation method thereof are provided. Add wollastonite powder into n-butanol at a mass volume ratio of 12g: 100mL, place it in a ball mill jar for mechanical ball milling at a speed of 200rpm for 2 hours; then ultrasonically disperse the milled slurry with an ultrasonic power of 35W, The frequency is 40kHz; after ultrasonication for 10min, at a stirring speed of 200rpm, the above-mentioned dispersion liquid is added dropwise to the silk fibroin solution with a mass fraction of 15% at a stirring speed of 200rpm to control the transformation of wollastonite and silk fibroin. The mass ratio of the protein was 40:100; the mixed suspension was frozen in a refrigerator at -15°C for 12 hours, and then thawed at room temperature for 6 hours to obtain a white silk fibroin scaffold, which was washed with deionized water and washed. After n-butanol, the scaffold was freeze-dried to obtain a comp...

Embodiment 3

[0033] A novel calcium magnesium silicate and silk fibroin composite porous scaffold and a preparation method thereof are provided. The magnesium-doped calcium silicate powder was added to n-butanol at a mass volume ratio of 20g: 100mL, and placed in a ball mill jar for mechanical ball milling at a speed of 200rpm for 2 hours; then the milled slurry was ultrasonically dispersed, and the ultrasonic power was 35W, the frequency is 40kHz; after ultrasonication for 10min, at a stirring speed of 200rpm, the above dispersion liquid is added dropwise to the silk fibroin solution with a mass fraction of 20% at a stirring speed of 200rpm to control the magnesium-doped silicic acid The mass ratio of calcium to silk fibroin is 50:100; the mixed suspension is placed in a -10°C refrigerator for 16 hours, and then thawed at room temperature for 6 hours to obtain a white silk fibroin scaffold, which is cleaned with deionized water Scaffolds were washed with n-butanol and freeze-dried to obta...

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Abstract

The invention discloses a novel calcium magnesium silicate and silk fibroin composite porous scaffold, and belongs to the technical field of preparation of bone defect repair medical materials, for solving the problem that the existing silk fibroin material is insufficient in osteoinduction and blood vessel forming property. The scaffold is composed of two materials including calcium magnesium silicate and silk fibroin, from the aspect of the natural bionic design, the inorganic and organic composite biological material with the porous structure is constructed by adopting the freeze drying technology, further, osteanagenesis is promoted, the flow is simple, the time needed by preparation is short, the needed materials are low in cost, the production cost is low, and the constitution and structure of the in-vivo human bone are simulated; and through the combination of the calcium magnesium silicate and silk fibroin, the mechanical strength of the composite porous scaffold is preferablyclose to the mechanical strength of the human cancellous bone, then a hydroxyapatite layer in good compatibility with the bone is formed, thus the effective osseointegration is formed, meanwhile, mechanical support is provided for the bone repair area, and further, the bone repair is promoted.

Description

technical field [0001] The invention relates to a calcium-magnesium silicate and silk fibroin composite scaffold with a porous structure and a preparation method thereof, especially in the technical field of preparation of medical materials for bone defect repair, and discloses a novel bone repair scaffold and a preparation method thereof . Background technique [0002] Bone defect repair requires scaffold materials with good biocompatibility, appropriate degradation rate, pore structure suitable for bone and blood vessel ingrowth, and matching mechanical strength of the defect area. Current scaffolds for bone tissue engineering focus on biomimetic bone composition and architecture. Silk fibroin is a natural protein material widely used in clinical practice. It has good biological and tissue compatibility, good mechanical properties, adjustable degradation performance, wide sources, and simple preparation. It can be combined with hydroxyapatite and tricalcium phosphate and...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/56A61L27/50A61L27/22A61L27/10A61L27/54
CPCA61L27/10A61L27/227A61L27/50A61L27/54A61L27/56A61L2300/10A61L2300/412A61L2430/02C08L89/00
Inventor 林泽枫吴婷婷黄文汉查振刚夏虹张涛
Owner 林泽枫
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