Method for extracting high-purity collagen from bovine bone
A technology of pure collagen and extraction method, which is applied in the field of high-purity collagen extraction from bovine bone, can solve the problems of wide molecular weight distribution, high protein yield, and many impurity proteins, and achieves short extraction time, improved yield and purity. , the effect of improving biological activity
Active Publication Date: 2019-02-22
GUIZHOU MOUNT FANJING ECOLOGICAL AGRI INC
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Abstract
The invention relates to the technical field of bio-collagen preparation, in particular to a method for extracting high-purity collagen from bovine bone. The method includes the following steps: the step S1 of washing fresh bovine bone clean; the step S2 of putting the washed bovine bone into a reactor, adding an ethanol solution, ventilating and conducting sealed reaction to form bovine bone pulp; the step S3 of treating the bovine bone pulp with a high pressure homogenizer to form uniform bovine bone pulp; the step S4 of adding an acidic solution to the bovine bone pulp, mixing uniformly, conducting ultra-high pressure impinging stream treatment, closed reactor treatment, high-voltage pulsed electric field treatment and closed reactor treatment, conducting solid and liquid separation with a filter press to obtain an extract; the step S4 of conducting ultrafiltration treatment on the extract to collect an ultrafiltrate and conducting spray drying to obtain the collagen. The purity ofthe collagen is 98% or more, the yield of the collagen is 90% or more, the biological activity of the collagen is improved, the absorption rate of the human body is increased to more than 98.5%, and the extraction time is short.
Application Domain
Connective tissue peptidesPeptide preparation methods
Technology Topic
UltrafiltrationChemistry +14
Examples
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PUM
Property | Measurement | Unit |
Molecular weight | 0.7 | |
Molecular weight | 0.1 | |
Molecular weight | 0.5 |
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