A kind of attenuated strain of muscovy duck C subtype avian metapneumovirus and its preparation and application

A technology of avian metapneumovirus and attenuated strains, applied in the direction of viruses, antiviral agents, viruses/phages, etc.
CN109402065BActive Publication Date: 2021-07-30WENS FOODSTUFF GRP CO LTD

Patent Information

Authority / Receiving Office
CN Β· China
Patent Type
Patents(China)
Current Assignee / Owner
WENS FOODSTUFF GRP CO LTD
Publication Date
2021-07-30

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Abstract

The invention belongs to the field of microbial animal viruses, and in particular relates to an attenuated strain of muscovy duck subtype C avian metapneumovirus and its preparation and application. The attenuated Muscovy duck subtype C avian metapneumovirus strain of the present invention has a preservation number of CCTCC NO: V201823, a nucleotide sequence of SEQ ID NO: 1, and an amino acid sequence of SEQ ID NO: 2 to SEQ ID NO: 9. The attenuated muscovy duck subtype C avian metapneumovirus strain of the present invention is prepared by subculturing the C subtype avian metapneumovirus S-01 strain to 50 generations. The invention obtains the attenuated culture strain of Muscovy duck subtype C avian metapneumovirus S-01 strain for the first time, laying a foundation for the development of the attenuated vaccine.
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Description

technical field

[0001] The invention belongs to the field of microbial animal viruses, and in particular relates to an attenuated strain of muscovy duck subtype C avian metapneumovirus and its preparation and application. Background technique

[0002] Avian metapneumovirus is one of the acute and highly contagious diseases of upper respiratory tract infection caused by avian metapneumovirus (aMPV). Avian lung disease was first isolated in young turkeys, accompanied by clinical symptoms such as sneezing, tracheal rales, sticky secretions in the nose and eyes, and conjunctivitis. Therefore it is called turkey rhinotracheitis. In South Africa in 1978, aMPV was first isolated and subsequently reported in Europe, Asia and South America. In 1998, my country first reported the isolation of avian pneumovirus A subtype in chickens with swollen head syndrome, and in 2012, B and C subtypes were successively isolated in chickens. In July 2010, in a duck farm in Guangdong Province, a ...

Claims

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