Nano-hydroxyapatite-coated porous titanium scaffold and its preparation method and application

A nano-hydroxyapatite and porous titanium technology, applied in the field of biomedical materials, can solve the problems of less tumor cell apoptosis and no local tumor recurrence, and achieve inhibition of tumor growth, good apoptosis of cancer cells, and good application prospects. Effect

Active Publication Date: 2021-04-06
CHANGZHOU GEASURE MEDICAL DEVICES CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this scaffold did not solve the problem of local tumor recurrence caused by residual bone tumor cells
[0006] At present, bone tumors are relatively common, and the application of existing technologies in the speed of defect repair after tumor surgery and the apoptosis of residual tumor cells is still relatively small, which has become a direction for the research and development of bone tumor repair materials

Method used

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  • Nano-hydroxyapatite-coated porous titanium scaffold and its preparation method and application
  • Nano-hydroxyapatite-coated porous titanium scaffold and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Example 1. Nano-hydroxyapatite-coated porous titanium stent

[0037] S1. Preparation of porous titanium substrate material

[0038] (1) Import the CT image into the simpleware 3D image software to obtain a 3D image of the target bone tissue. The average pore column is 500 μm and the average pore diameter is 300 μm. The image is filled and expanded with cubic porous units to obtain a personalized porous connected 3D digital model ;

[0039] (2) using a 3D printer, using titanium alloy as a raw material, and printing the porous titanium alloy stent according to the porous connected three-dimensional digital model designed in step (1);

[0040] S2, acid-base treatment is carried out to the porous titanium base material prepared in step S1, and a nano-scale microporous network TiO with a thickness of 0.5 μm is prepared on the pore wall and the surface of the skeleton 2 layer, the nanoscale microporous network TiO 2 layer porous titanium substrate material;

[0041] S3. Pr...

Embodiment 2

[0046] Example 2, nano-hydroxyapatite-coated porous titanium stent

[0047] S1. Preparation of porous titanium substrate material

[0048] (1) Import the CT image into the simpleware 3D image software to obtain a 3D image of the target bone tissue. The average pore column is 600 μm and the average pore diameter is 800 μm. The image is filled and expanded with octahedral porous units to obtain a personalized porous connected 3D digital image. Model;

[0049] (2) Use a 3D printer, use titanium alloy as raw material, and print a porous titanium alloy stent according to the design model;

[0050] S2. Alkaline heat treatment is performed on the porous titanium base material prepared in step S1, and a nanoscale microporous network TiO with a thickness of 2.0 μm is formed on the pore wall and the surface of the skeleton. 2 layer, the nanoscale microporous network TiO 2 layer porous titanium substrate material;

[0051] S3. Prepare nano-hydroxyapatite particle slurry by wet chemic...

Embodiment 3

[0056] Example 3, nano-hydroxyapatite-coated porous titanium stent

[0057] S1. Preparation of porous titanium substrate material

[0058] (1) Import the CT image into the simpleware 3D image software to obtain a 3D image of the target bone tissue. The average pore column is 400 μm and the average pore diameter is 600 μm. The image is filled and expanded with helical dodecahedral porous units to obtain personalized porous connectivity. 3D digital model;

[0059] (2) Use a 3D printer, use titanium alloy as raw material, and print a porous titanium alloy stent according to the design model;

[0060] S2, acid-base treatment is carried out to the porous titanium base material prepared in step S1, and a nanoscale microporous network TiO with a thickness of 1.2 μm is formed on the pore wall and the surface of the skeleton 2 layer, the nanoscale microporous network TiO 2 layer porous titanium substrate material;

[0061] S3. Prepare nano-hydroxyapatite particle slurry by wet chem...

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Abstract

The invention relates to the technical field of biomedical materials, in particular to a nano-hydroxyapatite-coated porous titanium bracket and a preparation method and application thereof. The nano-hydroxyapatite-coated porous titanium stent provided by the present invention includes a 3D printed porous titanium base material and a nano-hydroxyapatite coating; the surface of the 3D printed porous titanium base material forms a microporous network TiO 2 layer; the nano-hydroxyapatite coating is uniformly distributed in the microporous network TiO 2 layer surface. The invention also discloses a preparation method of the nano-hydroxyapatite-coated porous titanium bracket and its application in the preparation of bone tumor operation defect repair materials. The nano-hydroxyapatite-coated porous titanium scaffold provided by the present invention not only has a good osteogenic effect, but also can inhibit the growth of local residual tumor cells and reduce recurrence, showing good clinical application prospects.

Description

technical field [0001] The invention relates to the technical field of biomedical materials, in particular to a nano-hydroxyapatite-coated porous titanium bracket and a preparation method and application thereof. Background technique [0002] Bone tumors are tumors that occur in the bone and its adjunct tissues. There are benign and malignant tumors. Benign bone tumors are easy to cure and have a good prognosis. Malignant bone tumors develop rapidly, have a poor prognosis, and have a high mortality rate. Malignant bone tumors are divided into primary and secondary. The repair and reconstruction of segmental defects after surgery for secondary malignant bone tumors and the suppression of local tumor recurrence are an important clinical problem. [0003] At present, surgical resection is the main method for the treatment of bone tumors. Due to the advancement of chemotherapy methods, some scholars have begun to work on resection of tumor segments or total femur resection in re...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/06A61L27/56A61L27/32A61L27/30
CPCA61L27/06A61L27/306A61L27/32A61L27/56A61L2430/02
Inventor 朱向东杨晓周勇肖聪张坤屠重棋张兴栋
Owner CHANGZHOU GEASURE MEDICAL DEVICES CO LTD
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