New method for efficiently preparing diaryl methyl substituted organic phosphonates by using P (O)-H compound

Abstract

The invention provides a method for efficiently and selectively synthesizing diaryl methyl substituted organic phosphonate derivatives containing different substitute functional groups. The method uses cesium carbonate as a catalyst, and uses a P (O)-H compound and 4-arylmethylene-2, 6-di-tert-butyl 2, 5-cyclohexadiene-1-ketone compounds as reactants; an organic solvent is added into a reaction system. The method has the advantages that the catalyst is cheap and easy to obtain; the reactants are high in applicability; the reaction is mild in conditions, safe and reliable; the selectivity of the obtained target product is close to 100%, and the yield is as high as 90% or above. The method solves the problems that the conventional synthetic diaryl methyl substituted organic phosphonate derivatives are poor in reaction selectivity, tedious in reaction steps and low in yield, needs to use environmentally harmful reagents, and the like; the method has a good industrial application prospect.The invention also provides the corresponding diaryl methyl substituted organic phosphonate derivatives containing the different substitute functional groups.

Description

technical field [0001] The invention relates to the field of catalytic synthesis of organic phosphonate compounds, in particular to a method of combining P(O)-H compounds with 4-aryl methylene-2,6-di-tert-butyl-2,5 - A preparation method for the efficient 1,6-addition reaction of cyclohexadiene-1-one compounds to prepare diarylmethyl-substituted organic phosphonate derivatives. Background technique [0002] Diarylmethyl substituted organic phosphonates are an important class of intermediates in organic synthesis. They are widely used in the preparation of pharmaceutical structural substances, photoelectric materials, high-efficiency flame retardants, and catalyst ligands. Among the various organophosphorus compounds with different coordination, the research on one, two and six coordination compounds is the latest work, and their technology as organic synthesis building blocks is not yet mature. At present, organophosphorus reagents are mainly limited to three-, four-, and ...

AI Technical Summary

Problems solved by technology

However, the above methods generally adopt air-sensitive reagents (P(OR) 3 compounds, phosphorus oxychloride, etc.), special ligands (ferrocene ligands, carbene ligands, etc.) Defects such as utilization, harsh reaction conditions, cross-substrate applicability, low yield, and large environmental pollution

[0005] So far, the efficient synthesis of diarylmethyl-substituted organic phosphonate compounds has the quality of raw materials, the safety of production (compounds such as trialkyl phosphite and phosphorus oxychloride are highly corrosive) and the stability of products There are several problems such as purity and purity, and the synthesis technology is relatively difficult. At present, only a few companies in the United States, Japan and other countries are producing, and the current situation of my country's high-end organic phosphonate products mainly depends on imports.