Application of double-positive imidazolium salt ionic liquid in extraction of bisphenol compound and micro-extraction technology based on ionic liquid

A positive imidazolium salt, ionic liquid technology, applied in the field of analytical chemistry, can solve the problem of lack of micro-extraction technology, and achieve the effect of wide linear range, low detection limit and good reproducibility

Active Publication Date: 2019-03-15
WENZHOU MEDICAL UNIV
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  • Abstract
  • Description
  • Claims
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Problems solved by technology

[0005] Based on this, as far as the extraction technology is concerned, the use of double positive imidazolium salt ionic liquids may have better technical advantag

Method used

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  • Application of double-positive imidazolium salt ionic liquid in extraction of bisphenol compound and micro-extraction technology based on ionic liquid
  • Application of double-positive imidazolium salt ionic liquid in extraction of bisphenol compound and micro-extraction technology based on ionic liquid
  • Application of double-positive imidazolium salt ionic liquid in extraction of bisphenol compound and micro-extraction technology based on ionic liquid

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Experimental program
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Effect test

Embodiment 1

[0041] Experimental reagents: bisphenol A (BPA, 99% purity), bisphenol B (BPB, >98% purity), bisphenol AF (BPAF, 99% purity) and bisphenol Z (BPZ, 95% purity) were purchased from Sigma - Aldrich (West Chester, PA; USA). Chromatographic grade methanol and acetonitrile were purchased from Shanghai Merck Reagent Company. and 1-butyl-3-methylimidazolium tetrafluoroborate ([C4MIM]BF4) were purchased from Shanghai Chengjie Co., Ltd. The novel ionic liquid double-positive imidazolium bromide ([C4(MIM)2]Br2, [C6(MIM)2]Br2) was synthesized in the laboratory. Other chemical reagents were of analytical grade and purchased from Tianjin Chemical Reagent Co., Ltd.

[0042] Standard solution preparation: the preparation concentration is 1000μg mL -1 BPA, BPB, BPAF and BPZ mixed standard solution (4 ℃ standby).

[0043] Yili milk was purchased from Wenzhou Baixin Supermarket and stored at 4°C.

[0044] The water used in the experiment is ultrapure water (resistivity ≥ 18.2MΩ cm)

[0045] ...

Embodiment 2

[0073] Experimental reagent, instrument, process are as shown in embodiment 1, and its difference point is that used extraction agent is [C 6 (MIM) 2 ]Br 2 , adding LiNTf 2 Afterwards, ultrasonic treatment was performed for 1 to 9 minutes.

[0074] Experimental Results: Ultrasound Can Accelerate Organic Reaction, Contributes to LiNTf 2 Dissolve in the system solution, increase LiNTf 2 The probability of contact with the ionic liquid can accelerate the in-situ reaction, make the reaction more complete, and shorten the operation time.

[0075] Depend on Figure 9 It can be seen that when the ultrasonic time is between 1 and 9 minutes, the extraction rate is very considerable.

[0076] Among them, when the ultrasonic time increased from 1 minute to 3 minutes, the average extraction recovery of bisphenols increased from 74.08% to 84.60%; when the ultrasonic time continued to increase, the average extraction recovery of bisphenols appeared different degree of decline. The r...

Embodiment 3

[0078] Experimental reagent, instrument, process are as shown in embodiment 1, and its difference point is that used extraction agent is [C 6 (MIM) 2 ]Br 2 , The cooling time is 5-13 minutes.

[0079] Experimental results: if Figure 10 Shown, when cooling time is 5~13 minutes, its extraction rate is all very objective.

[0080] When the cooling time was increased from 5 minutes to 9 minutes, the average extraction recovery of bisphenols increased from 76.7% to 79.9%. This is because cooling can increase the viscosity of the ionic liquid, which is beneficial to its separation from water, and indirectly improves the extraction recovery rate of bisphenols. With the increase of cooling time, the recovery rate of bisphenols decreased from 79.9% to 73.4%, which may be due to the excessive cooling time and the high viscosity of the ionic liquid, which caused the ionic liquid to not be completely separated from the water phase during the centrifugation process. , thus reducing t...

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Abstract

The invention provides application of double-positive imidazolium salt ionic liquid in extraction of a bisphenol compound. Double-positive imidazolium salts ionic liquid comprises one or combination of [C4(MIM)2]Br2 and [C6(MIM)2]Br2. In addition, the invention further provides a micro-extraction technology based on the double-positive imidazolium salt ionic liquid, and an extracting agent is double-positive imidazolium salts ionic liquid with double imidazole rings. An extracting process comprises the steps of adding a to-be-extracted matrix in a centrifugal tube and then diluting the to-be-extracted matrix, then adding the extracting agent in the centrifugal tube to obtain mixed liquid, and regulating PH of the mixed liquid to be 2-6; then adding LiNTf2 in the mixed liquid and then carrying out ultrasonic treatment; and finally, cooling the mixed liquid and carrying out centrifuging treatment to obtain precipitates so as to complete extraction. The micro-extraction method as shown inthe invention has the advantages of simplicity and convenience in operation, time saving ability and high efficiency, and environmental protection. The method is wide in linear range, good in repeatability and low in limit of detection, and is suitable for detecting and analyzing the bisphenol compound in a complicated matrix.

Description

technical field [0001] The invention relates to the field of analytical chemistry, in particular to the application of a double positive imidazolium salt ionic liquid in the extraction of bisphenol compounds and a micro-extraction technology based on the double positive imidazolium salt ionic liquid. Background technique [0002] Bisphenol compounds are common chemical raw materials, which have been used in rubber products, pesticide production and other fields for a long time. Extraction technology is a commonly used substance extraction and detection technology, which is widely used in the fields of analytical chemistry and chemical industry. The detection of bisphenols in food or some complex matrices based on extraction technology has good application value. [0003] The Chinese invention patent with the patent number CN201210183094.1 discloses a rapid detection method for bisphenol A and bisphenol AF in food. The method adopts ionic liquid as an extractant and combine...

Claims

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Application Information

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IPC IPC(8): G01N30/06G01N30/14
CPCG01N30/06G01N30/14G01N2030/062G01N2030/146
Inventor 周佩佩王学东曲晋刚
Owner WENZHOU MEDICAL UNIV
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