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Phenylbenzofuran compound, preparation method thereof, composition and medical application

A compound, phenylbenzene technology, applied in the field of medicine, can solve the problems of increasing cancer burden and shortage of drugs for nasopharyngeal cancer, and achieve the effects of low production cost, easy purification, and mild reaction conditions

Active Publication Date: 2019-03-26
GUANGXI BOTANICAL GARDEN OF MEDICINAL PLANTS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the future, as my country's population aging continues to increase, the incidence and mortality of nasopharyngeal carcinoma may continue to rise, and the resulting cancer burden will continue to increase, and the prevention and control situation is severe. Currently, the effective treatment of nasopharyngeal carcinoma medicines are in short supply

Method used

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  • Phenylbenzofuran compound, preparation method thereof, composition and medical application
  • Phenylbenzofuran compound, preparation method thereof, composition and medical application
  • Phenylbenzofuran compound, preparation method thereof, composition and medical application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0061] Chinese medicine extraction method of phenylbenzofuran compound

[0062] The specific process of Chinese medicine extraction method:

[0063] Step 1, extracting the pea root coarse powder with 75% ethanol solution in parts by mass (specifically, multiple extractions can be carried out, and each extraction is separated by one week) to obtain the extract, and the ethanol solution is removed under reduced pressure, and the extract is concentrated to obtain Concentrate, the mass ratio of bean root meal to ethanol solution is 1:3, and the amount of bean root meal is 55kg;

[0064] Step 2, adjusting the pH of the concentrate to 2 with a hydrochloric acid solution with a concentration of 0.4M, and extracting with ethyl acetate, collecting the organic phase, removing the ethyl acetate and concentrating to obtain an extract;

[0065] Step 3. First, purify the extract by silica gel column chromatography. The elution system is a chloroform-methanol system, and collect the eluate...

Embodiment 2

[0066] Chinese medicine extraction method of phenylbenzofuran compound

[0067] The specific process of Chinese medicine extraction method:

[0068] Step 1, extracting the pea root coarse powder with 75% ethanol solution in parts by mass (specifically, multiple extractions can be carried out, and each extraction is separated by one week) to obtain the extract, and the ethanol solution is removed under reduced pressure, and the extract is concentrated to obtain Concentrate, the mass ratio of bean root meal to ethanol solution is 1:4, and the amount of bean root meal is 55kg;

[0069] Step 2, adjusting the pH of the concentrate to 3 with a hydrochloric acid solution with a concentration of 0.4M, and extracting it with ethyl acetate, collecting the organic phase, removing the ethyl acetate and concentrating to obtain an extract;

[0070] Step 3. First, purify the extract by silica gel column chromatography, the elution system is a chloroform-methanol system, and collect the elu...

Embodiment 3

[0071] Chinese medicine extraction method of phenylbenzofuran compound

[0072] Step 1, extracting the pea root coarse powder with 75% ethanol solution in parts by mass (specifically, multiple extractions can be carried out, and each extraction is separated by one week) to obtain the extract, and the ethanol solution is removed under reduced pressure, and the extract is concentrated to obtain Concentrate, the mass ratio of bean root meal and ethanol solution is 1:5, and the amount of bean root meal is 55kg;

[0073] Step 2, adjusting the pH of the concentrate to 4 with a hydrochloric acid solution with a concentration of 0.4M, and extracting with ethyl acetate, collecting the organic phase, removing the ethyl acetate and concentrating to obtain an extract;

[0074] Step 3. First, purify the extract by silica gel column chromatography. The elution system is a chloroform-methanol system, and collect the eluate with a volume ratio of chloroform-methanol of 20:1 to obtain the fir...

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Abstract

The invention discloses a phenylbenzofuran compound, a preparation method thereof, a composition and medical application. The structure of the phenylbenzofuran compound is shown in the description. The invention further discloses a traditional Chinese medicine extraction method of extracting the phenylbenzofuran compound from radix sophorae tonkinensis powder, and a chemical synthesis method of the phenylbenzofuran compound. An active ingredient of the composition containing the phenylbenzofuran compound is the phenylbenzofuran compound. The phenylbenzofuran compound is applied in preparationof drugs or food or health products for preventing or treating tumors, and particularly the tumor is nasopharyngeal carcinoma. The phenylbenzofuran compound can be prepared by the traditional Chinesemedicine extraction method and the chemical synthesis method, and phenylbenzofuran is proven to be have a certain inhibitory effect on nasopharyngeal carcinoma cells CNE-1 and CNE-2 by in-vitro tumorcell experiments.

Description

technical field [0001] The invention relates to the technical field of medicine. More specifically, the present invention relates to a phenylbenzofuran compound, its preparation method, composition and medical application. Background technique [0002] Nasopharyngeal carcinoma has become the main cancer and cause of death in malignant tumors of the ear, nose, and throat. The incidence rate in my country decreases from south to north, especially in Guangdong and Guangxi. The incidence rate increases with age in people over 20 years old and reaches a peak at around 45 to 60 years old. The etiology of nasopharyngeal carcinoma may be related to factors such as heredity, environment, and Epstein-Barr virus infection. The current effective treatment method advocates intensity-modulated radiotherapy. In the future, as my country's population aging continues to increase, the incidence and mortality of nasopharyngeal carcinoma may continue to rise, and the resulting cancer burden w...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D493/04A61K31/36A23L33/105A61P35/00
CPCA61P35/00A23L33/105C07D493/04A23V2002/00A23V2200/308A23V2250/2132A23V2300/14A23V2250/30B01D15/426B01D15/325B01D11/0288B01D11/0492A23L33/40
Inventor 缪剑华吴玲玲宋志军闫炳雄周小雷王硕姚彩云
Owner GUANGXI BOTANICAL GARDEN OF MEDICINAL PLANTS