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Micro-ecological preparation by using lactic acid bacteria to ferment radix astragali, preparation method and application thereof

A micro-ecological preparation, lactic acid bacteria fermentation technology, applied in the application, medical preparations containing active ingredients, antidote and other directions, can solve the problems such as the inability to obtain the effective active substances of astragalus original fermentation, achieve shortening production time, simple operation steps, The effect of increasing the release rate

Active Publication Date: 2019-03-29
内蒙古蒙肽生物工程有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This method adopts high-sugar fermentation, and adopts Chinese herbal medicinal juice to carry out fermentation, can't obtain the effective active substance of astragalus original fermentation

Method used

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  • Micro-ecological preparation by using lactic acid bacteria to ferment radix astragali, preparation method and application thereof
  • Micro-ecological preparation by using lactic acid bacteria to ferment radix astragali, preparation method and application thereof
  • Micro-ecological preparation by using lactic acid bacteria to ferment radix astragali, preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] The preparation method of the microecological preparation of astragalus fermented by lactic acid bacteria, said method S1 of preparing the microecological preparation of astragalus fermented by lactic acid bacteria comprises the following steps:

[0048] Step S11, preparation of Astragalus powder: take Mongolian Astragalus traditional Chinese medicine decoction pieces, remove residual dust and sand, and pulverize with a traditional Chinese medicine pulverizer.

[0049] Specifically, take Mongolian Astragalus decoction pieces and put them in a drying oven at 60-70 degrees Celsius, bake for 5-6 hours, take the dried Astragalus decoction pieces and pass through a 16-mesh sieve, and the crushed Astragalus membranaceus powder through a 40-mesh sieve for later use.

[0050] Step S112, preparation of astragalus medicinal liquid: take a certain amount of astragalus powder, add distilled water to decoct 3 times, combine the filtrates and concentrate.

[0051] Specifically, the s...

Embodiment 2

[0068] The application effect of the microecological preparation of lactic acid bacteria fermented Astragalus membranaceus in the animal experiment of enhancing immunity.

[0069] 1 Materials and methods

[0070] 1.1 Experimental materials

[0071] 1.1.1 Experimental animals: 70 clean-grade male Balb / c mice and mouse food were purchased from the Experimental Animal Center of Hebei Medical University.

[0072] 1.1.2 Dosage grouping: the lactic acid bacteria fermented Astragalus root fermented liquid prepared in Example 1 was converted into crude drug 5g / day, 10g / day, 20g / day of human body dosage 10 times as the dosage for mice, and three dosage groups of low, medium and high were set; The positive dose group was set up with pidotimod granules as the positive drug; the blank dose group was set up with normal saline.

[0073] 1.2 Experimental method

[0074] 1.2.1 Experimental grouping

[0075] After a week of adaptive feeding, 60 mice with a weight of 18-22 g and good condit...

Embodiment 3

[0102] The application effect of the microecological preparation of lactic acid bacteria fermented astragalus membranaceus in the animal experiment of relieving physical fatigue.

[0103] 1 Materials and methods

[0104] 1.1 Experimental materials

[0105] 1.1.1 Experimental animals: 70 clean-grade male Kunming mice and mouse food were purchased from the Experimental Animal Center of Hebei Medical University.

[0106] 1.1.2 Dosage grouping: the lactic acid bacteria fermented Astragalus root fermented liquid prepared in Example 1 was converted into crude drug 5g / day, 10g / day, 20g / day of human body dosage 10 times as the dosage for mice, and three dosage groups of low, medium and high were set; The positive dose group was set up with Xiaomeiling Granules as the positive drug; the blank dose group was set up with normal saline.

[0107] 1.2 Experimental method

[0108] 1.2.1 Experimental grouping

[0109] After a week of adaptive feeding, 60 mice with a weight of 18-22 g in g...

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Abstract

The present invention belongs to the technical field of bio-fermentation of traditional Chinese medicines and particularly relates to a micro-ecological preparation by using lactic acid bacteria to ferment radix astragali, a preparation method and an application thereof. The micro-ecological preparation by using the lactic acid bacteria to ferment the radix astragali is prepared by lactobacillus bulgaricus and lactobacillus acidophilus on a fermentation substrate containing radix astragali powder, wherein the fermentation substrate comprises the following components in mass percentages: 1-20%of radix astragali powder, 5-20% of milk powder, 1-5% of sucrose and 0.01-0.5% of a yeast extract. The micro-ecological preparation is prepared by using microorganisms to ferment the radix astragali powder, also selects a suitable fermentation temperature and fermentation time, and improves synergistic effects of the radix astragali and probiotics. The micro-ecological preparation used as health-care food or functional beverages can be used for relieving physical fatigue, improving body metabolism, promoting gastrointestinal functions, and enhancing mechanism immunity.

Description

technical field [0001] The invention belongs to the technical field of biological fermentation of traditional Chinese medicines, in particular to a microecological preparation of astragalus fermented by lactic acid bacteria and its preparation method and application. technical background [0002] In modern life, the pace of work and life of people is accelerating day by day, and they are in a state of high pressure and mental tension for a long time. People often find themselves lack of energy, memory decline, slow thinking, and then general fatigue. If fatigue is not eliminated in time, it will gradually accumulate, eventually leading to overwork, overtraining syndrome and chronic syndrome, etc., causing endocrine disorders, decreased immunity, and even organic diseases, which become threats. An important factor for human physical and mental health. [0003] The theory of traditional Chinese medicine believes that fatigue is mostly caused by exhaustion of qi, deficiency of...

Claims

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Application Information

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IPC IPC(8): A61K36/481A61P39/00A61P1/14A61P37/04A23L33/00A61K125/00
CPCA23V2002/00A61K36/481A61K2236/19A61K2236/331A23L33/00A61P1/14A61P37/04A61P39/00A23V2200/324A23V2200/30A23V2200/32
Inventor 逯振宇温宇旗王耀新陈丽娜韩国庆王继明杜芳魏鹏飞
Owner 内蒙古蒙肽生物工程有限公司
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