Preparation method of aspartame-acesulfame salt

A technology of aspartame acetyl and sulfamic acid, which is applied in the chemical industry and can solve the problem of low yield of aspartame acesulfame, KCl residues, affecting product taste and quality, etc. problems, to achieve the effect of low cost, high yield and simple method

Inactive Publication Date: 2019-03-29
CHANGMAO BIOCHEMICAL ENG CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] But in the preparation process of aspartame acesulfame in the prior art, easily have KCl residue, affect the mouthfeel and the quality of product, and avoid the technique that KCl produces in the prior art, aspartame Low yield of methyl acesulfame

Method used

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Examples

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preparation example Construction

[0011] A preparation method for aspartame acesulfame, comprising the following steps:

[0012] First, prepare an aqueous solution of aspartame;

[0013] Aspartame and water are mixed in a mass ratio of 1:6-20, and water is used as a solvent because water is more environmentally friendly and can fully dissolve aspartame in the future, and can avoid aspartame Potassium chloride is produced in acesulfame acid methyl ester acesulfame. If it is replaced by other solvents, such as alcohol solvents and ether solvents, the above solvents are likely to cause environmental pollution. At the same time, when the finished product is separated out later, potassium chloride will Precipitation, which in turn leads to residual potassium chloride in aspartame acesulfame.

[0014] And control the consumption of aspartame and water, be more conducive to carry out follow-up reaction, further avoid the generation of potassium chloride, be conducive to the carrying out of reaction simultaneously, t...

Embodiment 1

[0031] The present embodiment provides a kind of preparation method of aspartame acesulfame, comprising the following steps:

[0032] Add 485 grams of aspartame to 2910 grams of water and stir, then add 190 grams of 31% hydrochloric acid solution with stirring, and stir at a temperature of 50°C until the solution is clear. Then add 348 grams of acesulfame potassium, adjust the pH to 2.2 with potassium hydroxide, and stir for 1 hour while maintaining the temperature at 50°C. Then carry out cooling and crystallization at 18°C ​​for 2 hours, centrifuge, and vacuum dry the solid obtained by centrifugation. The drying temperature is 20°C, and the drying time is 10 hours. The finished product obtained after drying is 758 grams. The yield is 91.0%, its purity meets the national standard, and does not contain potassium chloride.

[0033] The centrifuged mother liquor is then filtered, and the mother liquor is cross-flow filtered by a nanofiltration membrane with a molecular weight of...

Embodiment 2

[0035] The present embodiment provides a kind of preparation method of aspartame acesulfame, comprising the following steps:

[0036] 240 grams of aspartame was added to 2400 grams of water, and stirred, and then 114 grams of 31% hydrochloric acid solution was added with stirring, and stirred at a temperature of 45° C. until the solution became clear. Then add 150 g of acesulfame potassium, adjust the pH to 3.0 with potassium hydroxide, and stir for 1.5 hours while maintaining the temperature at 45°C. Then carry out cooling crystallization under the condition of 25 ℃ for 1 hour, centrifuge, and carry out vacuum drying to the solid obtained by centrifugation, the drying temperature is 90 ℃, the drying time is 2 hours, the finished product obtained after drying is 352.3 grams, The yield is 90.3%, its purity meets the national standard, and does not contain potassium chloride.

[0037] The centrifuged mother liquor is then filtered, and the mother liquor is cross-flow filtered b...

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Abstract

The invention relates to the technical field of chemical engineering, in particular to a preparation method of aspartame-acesulfame salt. The preparation method of the aspartame-acesulfame salt comprises the following steps of: mixing an aspartame aqueous solution with acesulfame, regulating pH (Potential of Hydrogen) to 1.2 to 4.0, and mixing for reacting under the condition that the temperatureis 20 to 65 DEG C, thus forming the aspartame-acesulfame salt. By adopting the aspartame aqueous solution and controlling the pH value and the reaction temperature, remaining of potassium chloride canbe effectively avoided, and the yield is ensured; the preparation method is simple and convenient, equipment requirements are simple, the yield of obtained products is 90 percent or above, the cost is low, and the preparation method is suitable for industrial production.

Description

technical field [0001] The invention relates to the technical field of chemical engineering, in particular to a method for preparing aspartame acesulfame. Background technique [0002] Aspartame Acesulfame is a new type of high-intensity sweetener, which is a compound chemically synthesized by the optimal combination of aspartame and acesulfame in a specific form, and its characteristic is that it is in solution It can be completely dissociated into aspartame and acesulfame potassium, which is non-hygroscopic and soluble. It has better stability, no heat and no caries than aspartame and acesulfame at higher temperature. And its sweetness is about 340 times the sweetness of sucrose, while aspartame and acesulfame potassium are 200 times sweeter when used alone, which means that the required sweetener can be obtained with less sweetener. Sweetness, reduce the cost accordingly. [0003] But in the preparation process of aspartame acesulfame in the prior art, easily have KCl ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D291/06C07C237/12C07C231/12C07C231/24
CPCC07C231/12C07C231/24C07C237/12C07D291/06
Inventor 李建吉高有军潘春万屹东
Owner CHANGMAO BIOCHEMICAL ENG CO LTD
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