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Bactericidal nanocluster, preparation method and application thereof

A bactericidal effect and nano-cluster technology, applied in the field of nano-cluster and its preparation, can solve the problems of changing bacterial permeability and respiratory function, easy to produce drug resistance, high biological toxicity, etc., and achieve excellent water solubility and great application value , low toxicity effect

Active Publication Date: 2019-03-29
HEFEI UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Nanoparticles have small particle size and high specific surface area, and can quickly adsorb on the surface of cell membranes, significantly changing the physiological functions of bacteria such as permeability and respiratory function, leading to bacterial death. However, pure inorganic nanoparticles (such as silver nanoparticles) have higher The advantages of high bactericidal efficiency and wide bactericidal range, but its biological toxicity is high, pure nano-clusters have good physical and chemical stability, low toxicity, but low bactericidal efficiency, narrow bactericidal range and easy to produce drug resistance, polymerization The combination of objects and nanoclusters can effectively combine the advantages of the two to avoid disadvantages, and has broad application prospects

Method used

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  • Bactericidal nanocluster, preparation method and application thereof
  • Bactericidal nanocluster, preparation method and application thereof
  • Bactericidal nanocluster, preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0053]1. Under nitrogen protection, 0.028g (0.0001mol) 4-cyano-4-(phenylthioformylthio) valeric acid, 0.0016g (0.00001mol) azobisisobutyronitrile (AIBN), 2.7 g (0.009mol) polyethylene glycol monomethyl ether methacrylate (OEGMA-300), 0.36g (0.001mol) polyethylene glycol methacrylate (OEGMA-360), 0.007928g (0.00004mol) ethylene glycol Add alcohol dimethacrylate (EGDMA) into the Shrek tube, add 10ml N,N'-dimethylformamide as a solvent, and perform three cycles of pumping-freezing-gassing, each cycle is done 10 times. After the cycle was completed, the temperature was raised to 70° C., the reaction was stirred for 12 h, settled in n-hexane, and then vacuum-dried. Hydrophilic nanoclusters containing hydroxyl groups were obtained with a yield of 98%;

[0054] 2. With 2.98 g of hydrophilic nano-clusters containing hydroxyl prepared in step 1 as raw material, add 0.85 g (0.004 mol) bromohexanoyl chloride, 0.606 g (0.006 mol) triethylamine (TEA), add 10ml of N,N'-dimethylformamide a...

Embodiment 2

[0059] 1. Under nitrogen protection, 0.014g (0.00005mol) 4-cyano-4-(phenylthioformylthio) pentanoic acid, 0.0032g (0.00002mol) azobisisobutyronitrile (AIBN), 2.4 g (0.008mol) polyethylene glycol monomethyl ether methacrylate (OEGMA-300), 0.72g (0.002mol) polyethylene glycol methacrylate (OEGMA-360), 0.003964g (0.00002mol) ethylene glycol Add alcohol dimethacrylate (EGDMA) into the Shrek tube, add 20ml of dioxane as a solvent, and perform three cycles of pumping-freezing-inflating, 15 times for each cycle. After the cycle was completed, the temperature was raised to 80° C., the reaction was stirred for 10 h, settled in n-hexane, and then vacuum-dried. Hydrophilic nanoclusters containing hydroxyl groups were obtained with a yield of 90%;

[0060] 2. With 2.81 g of hydrophilic nano-clusters containing hydroxyl prepared in step 1 as raw material, add 0.64 g (0.003 mol) bromohexanoyl chloride, 0.505 g (0.005 mol) triethylamine (TEA), add 20ml dioxane as solvent. After reacting f...

Embodiment 3

[0065] 1. Under nitrogen protection, 0.028g (0.0001mol) 4-cyano-4-(phenylthioformylthio) valeric acid, 0.0016g (0.00001mol) azobisisobutyronitrile (AIBN), 2.7 g (0.009mol) polyethylene glycol monomethyl ether methacrylate (OEGMA-300), 0.36g (0.001mol) polyethylene glycol methacrylate (OEGMA-360), 0.007928g (0.00004mol) ethylene glycol Add alcohol dimethacrylate (EGDMA) into the Shrek tube, add 15ml N,N'-dimethylformamide as a solvent, and perform three cycles of pumping-freezing-gassing, each cycle is done 10 times. After the cycle was completed, the temperature was raised to 70° C., the reaction was stirred for 16 h, settled in n-hexane, and then vacuum-dried. Hydrophilic nanoclusters containing hydroxyl groups were obtained with a yield of 89%;

[0066] 2. With 2.65 g of hydrophilic nano-clusters containing hydroxyl prepared in step 1 as raw material, add 0.64 g (0.003 mol) bromohexanoyl chloride, 0.505 g (0.005 mol) triethylamine (TEA), add 15ml of N,N'-dimethylformamide ...

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Abstract

The invention discloses a bactericidal nanocluster, a preparation method and application thereof. Specifically, the bactericidal nanocluster has a structural formula shown as the specification, wherein the numerical intervals of x, y and z are 1-100 respectively, m is 4 or 5, and n is 5 or 6. The bactericidal nanocluster provided by the invention can be prepared into a solution of certain concentration to be directly sprayed to wound surfaces for treatment and prevention of various bacterial infections. The bactericidal nanocluster provided by the invention has good water solubility. The solution can reach a best effect under a concentration of 5-30microg / mL in terms of the concentration of contained silver particles, and mouse wounds can be completely healed in 6-8d.

Description

technical field [0001] The invention relates to a water-soluble cross-linked nanometer polymer, in particular to a nanocluster with bactericidal effect and its preparation method and application. Background technique [0002] Staphylococcus aureus is a Gram-positive spherical bacterium arranged in grape clusters under the microscope. It is a common pathogen that causes food poisoning. Commonly found on the skin surface and upper respiratory tract mucosa. The U.S. Centers for Disease Control reports that infections caused by Staphylococcus aureus are second only to Escherichia coli. Staphylococcus aureus is a pathogenic bacterium that causes serious infections, which can cause infections at different sites in the human body, ranging from mild superficial infections to deep and fatal infections, such as pneumonia, endocarditis, septicemia, osteomyelitis and other metastatic complications. [0003] Nanoparticles are nanoparticles between 1-200nm. It is mainly used as antiba...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08F290/06C08F8/00C08F8/34C08F8/14C08K3/08A61K33/38A61K9/14A61K47/34A61K9/08A61P31/04A61P31/02A61P17/02
CPCA61K9/0014A61K9/08A61K9/146A61K33/38A61P17/02A61P31/02A61P31/04C08F8/00C08F2438/03C08K3/08C08K2003/0806C08K2201/011C08F8/34C08F8/14C08F290/062
Inventor 何涛郭露荫左彦明闫旭陆杨徐晓莉
Owner HEFEI UNIV OF TECH
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