Fenbendazole microcapsules and preparation method thereof

A technology of fenbendazole microcapsules and fenbendazole, which is applied in the direction of microcapsules, capsule delivery, and pharmaceutical formulations, and can solve the problems of high efficiency, long-term, environmental protection, increase of drug treatment dose and course of treatment, Low bioavailability and other issues, to achieve the effect of enhancing the body's immunity, improving taste, and high bioavailability

Inactive Publication Date: 2019-04-05
FOSHAN STANDARD BIO TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

What is prepared at present is all fenbendazole single preparations, such as powders and tablets of fenbendazole, which can make the parasitic diseases of livestock and poultry effectively, but because the medicine is insoluble in water, the bioavailability of oral administration is low , in veterinary clinical use, it is necessary to increase the therapeutic dose and course of treatment of the drug, which is inconvenient to use and relatively high in cost, and does not have the characteristics of high efficiency, long-term effect and environmental protection of the ideal anthelmintic drug

Method used

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  • Fenbendazole microcapsules and preparation method thereof
  • Fenbendazole microcapsules and preparation method thereof
  • Fenbendazole microcapsules and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] A kind of fenbendazole microcapsule, comprises the component of following parts by weight:

[0031]

[0032]

[0033] A preparation method for fenbendazole microcapsules, comprising the following steps:

[0034] (1) Heat Span 60, astragalus polysaccharide, areca nut extract and PEG4000 to 80°C and stir for 1 hour to obtain an emulsion;

[0035] (2) Cool the emulsion obtained in step (1) to 70°C, add Tween 80 and fenbendazole and stir for 20 minutes, and turn on the emulsifier to emulsify for 30 minutes, and pass through the low-speed spray freezing granulation mechanism with a rotation speed of 1500r / min grain;

[0036] (3) Cool to room temperature and sieve to obtain fenbendazole microcapsules with a particle size of 500 μm.

Embodiment 2

[0038] A kind of fenbendazole microcapsule, comprises the component of following parts by weight:

[0039]

[0040] A preparation method for fenbendazole microcapsules, comprising the following steps:

[0041] (1) Heat Span 60, astragalus polysaccharide, areca nut extract and PEG4000 to 80°C and stir for 1 hour to obtain an emulsion;

[0042] (2) Cool the emulsion obtained in step (2) to 70°C, add Tween 80 and fenbendazole and stir for 20 minutes, turn on the emulsifier to emulsify for 30 minutes, and pass through a low-speed spray-freezing granulator with a rotation speed of 1500r / min to granulate ;

[0043] (3) Cool to room temperature and sieve to obtain fenbendazole microcapsules with a particle size of 500 μm.

Embodiment 3

[0045] A kind of fenbendazole microcapsule, comprises the component of following parts by weight:

[0046]

[0047] A preparation method for fenbendazole microcapsules, comprising the following steps:

[0048](1) Heat Span 60, astragalus polysaccharide, areca nut extract and PEG4000 to 80°C and stir for 1 hour to obtain an emulsion;

[0049] (2) Cool the emulsion obtained in step (1) to 70°C, then add Tween 80 and fenbendazole and stir for 20 minutes, turn on the emulsifier to emulsify for 30 minutes, and pass through a low-speed spray-freezing granulator with a rotation speed of 1500r / min to granulate ;

[0050] (3) Cool to room temperature and sieve to obtain fenbendazole microcapsules with a particle size of 500 μm.

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Abstract

The invention discloses fenbendazole microcapsules. The fenbendazole microcapsules are prepared from the following components in parts by weight: 5-20 parts of fenbendazole, 1-10 parts of an emulsifying agent, 3-13 parts of astragalus polysaccharide, 3-13 parts of an semen arecae extract and 50-100 parts of a carrier. The fenbendazole microcapsules provided by the invention have the characteristics of being reasonable in proportion, simple in preparation process, convenient to operate, good in stability and high in yield, and reducing the generation of dust. According to the invention, after the fenbendazole is subjected to microencapsulation, the half life of the fenbendazole can be prolonged, and the stability of medicine is improved; and in addition, due to the improvement of the astragalus polysaccharide and the synergistic effect of the semen arecae extract, the pharmaceutical effect of the fenbendazole reaches an optimal level.

Description

technical field [0001] The invention belongs to the technical field of veterinary medicine, and in particular relates to a fenbendazole sustained-release pellet and a preparation method thereof. Background technique [0002] With the rapid development of my country's poultry industry, the country's monitoring of animal drug use is becoming more and more strict, and the quality requirements of drugs are getting higher and higher. However, the traditional granule process will have complex manufacturing processes (including pre-treatment of raw materials, granulation, drying, granulation and packaging), poor uniformity of some drugs, high production costs, high requirements for packaging methods and materials, poor mobility and poor taste. [0003] Fenbendazole is white or off-white powder, odorless and tasteless. This product is soluble in dimethyl sulfoxide, slightly soluble in methanol, insoluble in water, soluble in glacial acetic acid. Fenbendazole is a benzimidazole anth...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/50A61K47/10A61K36/889A61P33/10A61K31/4184A61K31/715
CPCA61K9/5031A61K31/4184A61K31/715A61K36/889A61P33/10A61K2300/00
Inventor 陈艺青刘肖娟王俊谭志坚黎剑坤符德文黄显会
Owner FOSHAN STANDARD BIO TECH
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