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Novel antibiotic bone cement and preparation method thereof

A technology of antibiotics and bone cement, applied in tissue regeneration, pharmaceutical formulations, prostheses, etc., can solve the problems of poor antibiotic interaction, limited application, and unstudied thermal stability, etc., to achieve expanded antibacterial spectrum, good antibacterial properties, and improved The effect of the antibacterial effect

Active Publication Date: 2019-04-05
上海朗迈医疗器械科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, at that time, the interaction between the product of this system and antibiotics, especially those with poor thermal stability, as well as the stability and release characteristics of antibiotics in this system were not studied, and low-temperature polymerized bone fillers with excellent antibacterial properties have not yet been developed. material, limiting its application in bone tissue revision surgery

Method used

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  • Novel antibiotic bone cement and preparation method thereof

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Effect test

Embodiment 1

[0041] This embodiment relates to a novel antibiotic bone cement and its preparation method, the preparation method comprising the following steps:

[0042] Step 1, component A preparation:

[0043] (1) Matrix material preparation: Bisphenol A diglycidyl methacrylate (Bis-GMA) and triethylene glycol dimethacrylate (TEGDMA) were mixed with an electric stirrer for more than 12 h to make them evenly mixed. Bis-GMA accounts for 30 parts of the total mass of ingredients, and TEGDMA accounts for 28 parts of the total mass of ingredients.

[0044] (2) After preparing according to the base material, add benzoyl peroxide to the base material and continue mixing for more than 12 h. The initiator accounts for 0.5 part of the overall mass of the batching.

[0045] (3) After mixing (2), add 17.5 parts of zirconium dioxide, 20 parts of bioglass, and 4 parts of amoxicillin sodium, and make a paste by electric mixing. A production.

[0046] Step 2, component B preparation:

[0047] (1) M...

Embodiment 2

[0055] This embodiment relates to a novel antibiotic bone cement and its preparation method, the preparation method comprising the following steps:

[0056] Step 1, component A preparation:

[0057] (1) Matrix material preparation: Mix bisphenol A ethoxy dimethacrylate (Bis-GMA) and triethylene glycol dimethacrylate (TEGDMA) with an electric mixer for more than 12 hours to make them evenly mixed . Bis-GMA accounts for 20 parts of the total mass of ingredients, and TEGDMA accounts for 40 parts of the total mass of ingredients.

[0058] (2) After preparing according to the matrix material, add benzoyl tert-butyl peroxide to the matrix material and continue mixing for more than 12 hours. The initiator accounts for 0.3 parts of the overall mass of the batching.

[0059] (3) After mixing (2), add 23 parts of barium sulfate, 9.7 parts of bioglass, 5 parts of ciprofloxacin hydrochloride, and 2 parts of gentamicin sulfate, and mix and stir to form Paste substance, the preparation ...

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Abstract

The invention provides novel antibiotic bone cement and a preparation method thereof. The material comprises a component A and a component B; the component A comprises bisphenol A glycidyl methacrylate, triethylene glycol dimethacrylate, a developing agent, an inorganic filler, an initiator and an antibiotic; the component B comprises bisphenol A ethyoxyl dimethacrylate, triethylene glycol dimethacrylate, a developing agent, an inorganic filler, an accelerator and an antibiotic. The invention further relates to the preparation method of the material. According to the invention, various bone cement products containing different antibiotics are prepared, wherein the antibiotic with poor thermal stability can be inactivated due to heating when being used in PMMA (polymethyl methacrylate) bonecement so as to reduce or lose the antibacterial property, but is still kept having the excellent antibacterial property in the product provided by the invention, thereby expanding an antibiotic userange of the bone cement; moreover, compared to the PMMA bone cement containing the antibiotic in the market, the product provided by the invention is wider in antibacterial spectrum, higher in antibacterial property and smaller in toxic or side effect.

Description

technical field [0001] The invention relates to the field of biomedical materials, in particular to a novel antibiotic bone cement and a preparation method thereof. Background technique [0002] For a long time, there are millions of patients with bone tissue defect and destruction caused by disease, aging, accidental injury or war all over the world. At present, PMMA bone cement is mainly used in vertebroplasty, joint replacement and other operations, and its main component is acrylate copolymer and its monomer. However, such products will release a large amount of heat during use, with the highest temperature reaching 80°C or even higher, which exceeds the tolerance range of human tissues, causing necrosis of surrounding tissues; the complication of vertebroplasty is that PMMA enters the spinal canal Nerve damage, of which thermal burns are a significant factor. At the same time, the surrounding tissue necrosis caused by thermal burns will lead to aseptic loosening of th...

Claims

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Application Information

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IPC IPC(8): A61L27/54A61L27/50A61L27/10A61L27/12A61L27/02A61L27/16
CPCA61L27/025A61L27/10A61L27/12A61L27/16A61L27/50A61L27/54A61L2300/45A61L2300/406A61L2300/412A61L2400/06A61L2430/02A61L2300/102A61L2300/112C08L35/02
Inventor 刘恒何敏杨瑞郝刘男张宇轩吴顺顺
Owner 上海朗迈医疗器械科技有限公司
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