Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Composition, preparation and application of regenerative tissue matrix for microplastic surgery

A matrix composition and a technique for regenerating tissue, applied in the field of regenerative medicine, can solve the problems of easily producing antigenicity, and achieve the effect of easy cell adhesion and migration, and excellent filling effect

Active Publication Date: 2021-09-07
北京颢美细胞基因生物技术有限公司
View PDF0 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Heterogeneous collagen, easy to produce antigenicity and other disadvantages

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Composition, preparation and application of regenerative tissue matrix for microplastic surgery
  • Composition, preparation and application of regenerative tissue matrix for microplastic surgery
  • Composition, preparation and application of regenerative tissue matrix for microplastic surgery

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] 1) The raw material of allograft skin is put into 0.5-5% alkali glycerin solution, soaked at 35°C for 10 hours and shaken to obtain semi-finished product A;

[0052] 2) After removing the epidermis of the semi-finished product A, wash it with sterile pure water for 5 minutes, put it into a 0.3g / L SDS surfactant solution, ultrasonicate for 5 minutes at an ultrasonic frequency of 45KHz, and an ultrasonic temperature of 20°C, soak for 3 hours, and replace it with a new one Surfactant solution, repeat the treatment 3 times to get the semi-finished product B.

[0053] 3) Rinse the semi-finished product B with sterile pure water for 5 minutes, put it into 0.6% genipin water solution with a pH of 6.5 for cross-linking for 24 hours, and rinse it with sterile pure water for 5 minutes.

[0054] 4) Cut the semi-finished product B after step 3) to a size of (0.3~1)×(0.3~1)cm 2, immersed in liquid nitrogen for 10 min in an immersion manner to obtain a semi-finished product C.

[0...

Embodiment 2-5

[0060] The steps are the same as in Example 1, and the specific parameters are shown in Table 1.

[0061] Each parameter in table 1 embodiment 1-5 test procedure

[0062]

[0063]

[0064] Explanation: The particle size of the finished product that can pass through No. 14 and No. 20 sieves.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
concentrationaaaaaaaaaa
particle size (mesh)aaaaaaaaaa
Login to View More

Abstract

The present invention proposes a regenerated tissue matrix composition, preparation and application for micro-shaping. The regenerated tissue matrix composition includes regenerated tissue matrix particles, hydroxyethyl starch and carboxymethyl cellulose; the regenerated tissue matrix The microparticles contain extracellular matrix in a microparticle state, and the regenerated tissue matrix microparticles are microparticles that can pass through a 100-mesh sieve but cannot pass through a 400-mesh sieve. The regeneration tissue matrix composition proposed by the present invention has a three-dimensional structure and good biocompatibility, so it can be used as tissue support, a scaffold for cell growth, and can be used as a filler in facial microplastic surgery. The minimally invasive injection product containing the composition of the present invention has no immune rejection in clinical use, and is suitable for injecting into the dermis to repair facial wrinkles or modify defective skin due to the reduction of collagen and elastic fibers in the dermis. Good tissue repair effect.

Description

technical field [0001] The invention belongs to the field of regenerative medicine, and specifically relates to a composition containing a regenerative tissue matrix, a preparation method and application thereof. Background technique [0002] Micro-surgery is a high-tech medical technology. It does not require surgery and has the characteristics of becoming beautiful and younger in a short time. It has gradually replaced the plastic surgery in the past. It is safe, without wounds, and recovers Advantages of short term. The emergence of micro-plastic surgery makes plastic surgery as simple as cosmetic skin care, and the plastic surgery effect is exactly the same as traditional plastic surgery. Micro-plastic surgery includes many types of items, and its main implementation methods include Botox type A wrinkle removal and face-lifting, filler injection, autologous fat grafting, facial liposuction, laser treatment, injection of hyaluronic acid and whitening injections, etc. The...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/36A61L27/20A61L27/50A61L27/56
CPCA61L27/20A61L27/3633A61L27/3691A61L27/50A61L27/56A61L2400/06C08L1/286C08L3/08
Inventor 莫丽影孙善凤石卫华王姣王正元
Owner 北京颢美细胞基因生物技术有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com