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Absorbable bone wax with hemostasis function, and preparation method thereof

A bone wax and functional technology, applied in the field of biomedical materials, can solve the problems of foreign body reaction, poor biocompatibility of bone wax, and hinder the aggregation of blood components, etc., and achieve the effect of good biocompatibility and simple preparation process

Inactive Publication Date: 2019-04-26
PEKING UNION MEDICAL COLLEGE HOSPITAL CHINESE ACAD OF MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the traditional bone wax has poor biocompatibility and is difficult to be degraded and absorbed by the body. If it remains in the body, it will cause serious complications such as foreign body reaction and wound infection. There are even reports abroad that the spinal cord is compressed due to the loss of bone wax used, resulting in paralysis of the lower limbs; at the same time Traditional bone wax will hinder the aggregation of blood components (fibrin and platelets), which is not conducive to the formation of original callus and seriously affects the normal healing of bone

Method used

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  • Absorbable bone wax with hemostasis function, and preparation method thereof
  • Absorbable bone wax with hemostasis function, and preparation method thereof
  • Absorbable bone wax with hemostasis function, and preparation method thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] 1. Weigh each raw material component according to the weight ratio: 33.3% of cross-linked hyaluronic acid, 33.3% of calcium phosphate, and 33.4% of deionized water;

[0027] 2. Put the cross-linked hyaluronic acid and calcium phosphate in a reaction vessel, mix them well by magnetic stirring, then add deionized water and stir to obtain the bone wax;

[0028] 3. The obtained bone wax is sealed and packaged, and sterilized by ultraviolet light.

[0029] The results of electron microscopy scanning of the prepared materials are as follows: figure 1 Shown are the characterizations scanned at 20um and 50um respectively.

Embodiment 2

[0031] 1. Weigh each raw material component according to the weight ratio: 33.3% of cross-linked hyaluronic acid, 30% of calcium phosphate, 3.3% of soluble starch, and 33.4% of deionized water;

[0032] 2. Put the cross-linked hyaluronic acid and calcium phosphate in the reaction container, and mix them thoroughly by magnetic stirring;

[0033] 3. Add deionized water to the soluble starch, stir and heat to 60-70°C to make it pregelatinized, then add it to the reaction vessel in step 2 and mix well with other raw materials to obtain the bone wax;

[0034] 4. The obtained bone wax is sealed and packaged, and sterilized by ultraviolet light.

[0035] The results of electron microscopy scanning of the prepared materials are as follows: figure 2 Shown are the characterizations scanned at 20um and 50um respectively.

Embodiment 3

[0037] 1. Weigh each raw material component according to the weight ratio: 33.3% of cross-linked hyaluronic acid, 26.7% of calcium phosphate, 6.7% of soluble starch, and 33.3% of deionized water;

[0038] 2. Put the cross-linked hyaluronic acid and calcium phosphate in the reaction vessel, mix them thoroughly by magnetic stirring, and then add deionized water;

[0039] 3. Add deionized water to the soluble starch, stir and heat to 60-70°C to make it pregelatinized, then add it to the reaction vessel in step 2 and mix well with other raw materials to obtain the bone wax;

[0040] 4. The obtained bone wax is sealed and packaged, and sterilized by ultraviolet light.

[0041] The results of electron microscopy scanning of the prepared materials are as follows: image 3 Shown are the characterizations scanned at 20um and 50um respectively.

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Abstract

The invention discloses absorbable bone wax with a hemostasis function. The absorbable bone wax is prepared from the following raw materials: solid and water, wherein the solid is prepared from crosslinking hyaluronic acid, calcium phosphate and soluble starch; the weight of water is 20-100% of the weight of the solid; the weight ratio of the solid is that the ratio of the crosslinking hyaluronicacid, the calcium phosphate and the soluble starch is (20-70):(20-50):(0-10). According to the bone wax disclosed by the invention, the defects that traditional bone wax has poor biocompatibility, isnondegradable and affects bone healing can be eliminated. While a good hemostasis effect of the traditional bone wax is kept, the bone wax disclosed by the invention can be naturally degraded in the body without causing late period relevant complications due to residues.

Description

technical field [0001] The invention relates to the technical field of biomedical materials, in particular to an absorbable bone wax with a hemostatic function and a preparation method thereof. Background technique [0002] During orthopedic, thoracic, and neurosurgery operations, bone destruction is often involved, resulting in bleeding from the bone surface. Due to the rich blood supply, it is difficult to stop this bleeding by conventional methods such as electrocoagulation, forceps, hemostatic gauze, and gelatin sponge packing. Therefore, bone wax is often used clinically to stop bleeding on cancellous bone wounds. The main components of traditional bone wax are beeswax, vaseline, etc. Its hemostatic mechanism is to fill and seal the bleeding bone surface through the mechanical physical barrier, and it can stop bleeding quickly and is widely used in clinical practice. However, the traditional bone wax has poor biocompatibility and is difficult to be degraded and absorbe...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L24/08A61L24/02A61L24/00
CPCA61L24/0042A61L24/02A61L24/08A61L2430/02C08L5/08C08L3/02
Inventor 许德荣王海吴志宏邱贵兴李书纲
Owner PEKING UNION MEDICAL COLLEGE HOSPITAL CHINESE ACAD OF MEDICAL SCI
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