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Special membrane for disposable bioreactor and preparation method thereof

A bioreactor, disposable technology, applied in biochemical equipment and methods, bioreactor/fermenter combination, specific-purpose bioreactor/fermenter, etc., can solve the obstacles to the development of disposable bioreactors, increase Problems such as the use cost of domestic users and the unfavorable sustainable development of the industry have achieved the effect of improving the gas barrier function, reducing operating costs, and enhancing stability

Active Publication Date: 2021-04-13
石家庄育才药用包装材料股份有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The special membrane for disposable bioreactor is an important part of the reactor. At present, the main source of special membrane products is imported, which is not only expensive, but also increases the use cost of domestic users, and hinders the development of disposable bioreactors in my country. Realize the sustainable development of the industry

Method used

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  • Special membrane for disposable bioreactor and preparation method thereof
  • Special membrane for disposable bioreactor and preparation method thereof
  • Special membrane for disposable bioreactor and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0026] This embodiment relates to a special membrane for a disposable bioreactor and its preparation.

Embodiment 11

[0028] Disposable bioreactor special membrane, including an ultra-low density polyethylene layer placed in the innermost layer of the membrane body, a low density polyethylene layer placed in the outermost layer, an ethylene / vinyl alcohol copolymer layer in the middle of the membrane body, and An adhesive layer arranged between two adjacent layers;

[0029] Among them, the ultra-low-density polyethylene layer, the raw material formula is: 4 parts of ultra-low-density polyethylene of model PA66; 3 parts of ultra-low-density polyethylene of model POM; 1.5 parts of ultra-low-density polyethylene of model PTFE; 0.5 parts of ultra-low-density polyethylene of model PA6 share.

[0030] Among them, the low-density polyethylene layer, the raw material formula is: 4 parts of low-density polyethylene of model 2420D; 1 part of low-density polyethylene of model 2010MA; 1 part of low-density polyethylene of model LD100AC; Density polyethylene 0.5 parts.

[0031] The raw material formula o...

Embodiment 12

[0038] Disposable bioreactor special membrane, including an ultra-low density polyethylene layer placed in the innermost layer of the membrane body, a low density polyethylene layer placed in the outermost layer, an ethylene / vinyl alcohol copolymer layer in the middle of the membrane body, and An adhesive layer arranged between two adjacent layers;

[0039] Among them, the ultra-low-density polyethylene layer, the raw material formula is: 4 parts of ultra-low-density polyethylene of model PA66; 2 parts of ultra-low-density polyethylene of model POM; 2 parts of ultra-low-density polyethylene of model PTFE; 0.5 parts of ultra-low-density polyethylene of model PA6 share.

[0040] Among them, the low-density polyethylene layer, the raw material formula is: 5 parts of model 2420D low-density polyethylene; 2 parts of model 2010MA low-density polyethylene; 1 part of model LD100AC low-density polyethylene; 0.5 parts of model 2426H low-density polyethylene; Density polyethylene 0.5 pa...

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Abstract

The invention discloses a special membrane for a disposable bioreactor, which comprises an ultra-low-density polyethylene layer placed in the innermost layer of the membrane body, a low-density polyethylene layer placed in the outermost layer, and an ethylene / ethylene layer in the middle of the membrane body. An alcohol copolymer layer, and an adhesive layer arranged between two adjacent layers. The special membrane obtained for disposable bioreactors has high strength, good stability, and excellent pollution resistance, and can block the penetration of microorganisms, pathogenic bacteria, and sludge. The preparation method of the special film for the disposable bioreactor of the present invention ensures the smooth progress of the plasticizing reaction by controlling the head temperature of the film blowing machine to produce a special film with excellent performance. The preparation method is simple and efficient, and the disposable bioreactor is reduced The use cost of the reactor has significant economic benefits.

Description

technical field [0001] The invention relates to the field of membrane materials for bioreactors, in particular to a special membrane for a disposable bioreactor and a preparation method for the special membrane. Background technique [0002] Disposable bioreactors have been applied since the end of the 1990s, and are developing toward a more widespread trend. They are mainly used for microbial culture and cell culture in discontinuous or continuous processes at pilot scale and production scale. Used in clinical sample preparation and GMP manufacturing during development. Compared with traditional stainless steel or glass bioreactors, disposable bioreactors do not need to be cleaned and sterilized, which reduces the need for flushing water systems and maintenance, and eliminates the process because it cannot be used for subsequent operations The possibility of cross-contamination between runs also avoids the long cycle time of equipment assembly, and due to the reduced compl...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B32B27/08B32B27/32B32B7/12B32B27/30B29C69/02B29C48/08B29C48/21B29K23/00B29L7/00B29L9/00C12M1/00
CPCB29K2023/0608B29K2023/0633B29K2023/08B29L2007/00B29L2009/00B32B7/12B32B27/08B32B27/306B32B27/32B32B2250/24B32B2307/554B32B2307/7242C12M1/00
Inventor 尚国栋路文革秦孙星张昕蓓刘志
Owner 石家庄育才药用包装材料股份有限公司
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