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Liver support system

A technology of liver failure and sieving coefficient, applied in the field of artificial in vitro systems, can solve the problem of limited elimination performance

Active Publication Date: 2019-04-26
GAMBRO LUNDIA AB
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Currently used systems are known to be limited in their elimination performance (with respect to strongly bound toxins), especially with regard to unconjugated bilirubin

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0069] Preparation of a hollow fiber membrane dialyzer (3) comprising hollow fibers and particulate material in the filtrate space

[0070] Standard hollow fibers are used to prepare filter modules with active particulate material on the filtrate side. According to ISO8637:2004, the housing used has connectors on the blood side and the filtrate side. The total surface area of ​​the membrane is 1.7m 2 . The fibers are slightly curled. The housing diameter is 48 mm and the overall length (effective fiber length) is 270 mm. The potting material consists of polyurethane. The total amount of particulate material consisting of hydrophobic adsorbent (Purolite) and ion exchanger (cholestyramine) introduced into the filtrate space was 56.07 g. According to DIN ISO 3953, the tap density of these materials can be used to calculate the fill factor of the modules.

Embodiment 2

[0072] Hepatotoxin removal

[0073] Liver support system according to the invention (see figure 1 ) were tested in a recirculation test setup comprising the prototype of Example 1 as dialyzer (3), see figure 1 . The 3000ml test cell contains 75mg / l conjugated bilirubin (Sigma) and 25mg / l unconjugated bilirubin M W 842.9 (Calbiochem), and in 100 mg / l chenodeoxycholic acid (CDCA) (Sigma) in LG human plasma (blood group 0 from Octapharma); it was kept at about 37°C. The test cell also contained 5 ml of heparin (Heparin-Natrium-25000-ratiopharm). Add 60ml of 0.1M HCl to reach neutral pH. The test cell is always protected from light. The dialyzer was connected to the machine as specified and operated in CVVHDF mode. blood warmer ( II) Connect downstream and set to 38°C. The system was flushed with 2x21 NaCl 0.9% including 5000 IU / l heparin. Q B =200ml / min, Q D = 1.5 l / h and replacement fluid 1 l / h (total: 2.5 l / h). UF = 0 l / h. The system runs for 8h. Afterward...

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Abstract

The present invention relates to an artificial, extracorporeal system for supporting the function of the liver of a patient suffering from liver failure. The system is characterized in that the systemcomprises a first high-flux or high cut-off hollow fiber membrane dialyzer which is perfused on the lumen side with the patient's blood, with a buffered aqueous solution comprising human serum albumin being passed in a continuous flow through the filtrate space of said first dialyzer; a second hollow fiber membrane dialyzer which removes water-soluble substances from the dialysate of said first dialyzer; and a third, integrated hollow fiber membrane dialyzer which is perfused with the retentate of second hemodialyzer and which allows the passage of certain amounts of albumin over the membranewall into the filtrate space which is populated with adsorbent material. The system can be used for the treatment of acute liver failure and acute-on-chronic liver failure.

Description

technical field [0001] The present disclosure relates to an artificial extracorporeal system for liver replacement and / or liver assistance, comprising a liver dialysis device for performing hemodialysis on patients with liver failure, characterized in that the device comprises a first standard hollow fiber membrane dialysis perfused with the patient's blood; a second hollow fiber membrane dialyzer that removes water-soluble substances from the dialysate of the first dialyzer; and a third integrated hollow fiber membrane dialyzer that allows a specific amount of Albumin passes through the membrane wall and is perfused with dialysate leaving the second hemodialyzer ( figure 1 ). The filtrate space of the third integrated hollow fiber membrane dialyzer is only in fluid connection with the lumen space of the hollow fibers and is filled with a chemically and / or physically active adsorbent material, which may comprise one or more different substances, such as hydrophobic Adsorbent...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61M1/16A61M1/36B01D63/02
CPCA61M1/1696B01D61/28B01D69/02B01D2311/06B01D2311/2626B01D2317/025B01D2325/20A61M1/1633A61M1/1676B01D61/243B01D61/244
Inventor 拉尔夫·弗利格贝恩德·克劳泽马库斯·斯托尔
Owner GAMBRO LUNDIA AB
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