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Hyperuricaemia resisting urtica hyperborea overground part extract, and preparation method and application thereof

A nettle extract, a technology for hyperuricemia, applied in the field of medicine, can solve the problems such as the anti-hyperuricemia effect of high altitude nettle, which is beneficial to development and utilization, has a simple preparation process, and has no toxic and side effects. Effect

Inactive Publication Date: 2019-05-03
JIANGXI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, there is no report about the anti-hyperuricemia effect of highland nettle

Method used

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  • Hyperuricaemia resisting urtica hyperborea overground part extract, and preparation method and application thereof
  • Hyperuricaemia resisting urtica hyperborea overground part extract, and preparation method and application thereof
  • Hyperuricaemia resisting urtica hyperborea overground part extract, and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Example 1 Comparative analysis of components of plateau nettle, components of plateau nettle large polar parts and other species of nettle

[0040]At room temperature, after wetting the dry coarse powder of plateau nettle with 95% ethanol, pour it into the percolation bucket, add 95% ethanol until the liquid level is higher than the surface of the medicinal material, soak overnight, and then use 8-10 times the weight of the medicinal material 95% ethanol, 50% ethanol, and water gradient percolation, collect the percolation liquid in sections, concentrate under reduced pressure until it has no alcohol smell, and obtain 95% alcohol extract, 50% alcohol extract and water extract; After water-dispersing 95% alcohol extract and 50% alcohol extract, extract 95% alcohol extract and 50% alcohol extract successively with equal amounts of petroleum ether, ethyl acetate and n-butanol for 5- 7 times (until the organic phase is colorless), merge the same organic phases, and reclaim ...

Embodiment 2

[0046] Example 2 Investigation of the activity of the extract from the large polar part of the plateau nettle

[0047] Collect 11 kinds of Urtica medicinal materials respectively, accurately weigh 1g of dried medicinal herb powder of 11 kinds of Urtica medicinal plants, put them in a 100mL round bottom flask, add 25mL of methanol, shake well, put them in a 70℃ water bath for ultrasonic extraction for 30min, and statically Keep it cold, centrifuge the supernatant, pass through a 0.45 μm microporous membrane, and set aside.

[0048] See Example 1 for the preparation method of the large polar part extract of Urtica urtica plateau.

[0049] 1. Materials and methods

[0050] Allopurinol (purity ≥ 98%, HPLC assay) Sigma Company, St.Louis, MO; Oxonic acid potassium salt (purity ≥ 98%, HPLC assay) Sigma Company, St.Louis, MO); Uric acid assay kit ( Microplate method) (batch number: 20171114); urea test kit (batch number: 20180929); blood creatinine detection kit (batch number: 20181...

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Abstract

The invention provides a hyperuricaemia resisting urtica hyperborea overground part extract, and a preparation method thereof. The urtica hyperborea overground part extract is one or a mixture of twoof an n-butanol extract or an alcohol soluble position extract of urtica hyperborea overground parts. The urtica hyperborea overground part extract for resisting hyperuricaemia is from alcohol solublepositions of urtica hyperborea overground parts as Tibetan medicines, has the effect of resisting the hyperuricaemia, has the effects of restraining liver XOD vitality and adjusting and controlling gene expression of transporters of uric acid of kidney, and can be used for preparing hyperuricaemia resisting medicines.

Description

technical field [0001] The invention relates to the technical field of medicines, and relates to an effective anti-hyperuricemia active part extracted from Tibetan medicine plateau nettle and a preparation method thereof. Background technique [0002] Uric acid in the body is the final product of hypoxanthine and xanthine under the catalysis of xanthine oxidase. That is, the metabolic disorder of purine substances leads to increased production of uric acid, leading to an increase in the concentration of uric acid in the body, resulting in hyperuricemia (Hyperuricemia). Hyperuricemia is the biochemical basis of gout (Gout). Gout must be accompanied by hyperuricemia. With the continuous improvement of living standards and changes in dietary structure, the prevalence of gout and hyperuricemia is increasing year by year. At present, the drugs used clinically for the treatment of gout and hyperuricemia mainly include colchicine, non-steroidal anti-inflammatory drugs and glucoc...

Claims

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Application Information

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IPC IPC(8): A61K36/185A61P19/06
Inventor 钟国跃魏荣锐苏日娜罗维早朱继孝吴依静
Owner JIANGXI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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