Magnetism/temperature/pH tri-responsive nanogel and preparation method thereof

A nano-hydrogel and magnetic nano-technology, which is applied in the direction of pharmaceutical formulations, organic active ingredients, medical preparations of non-effective ingredients, etc., can solve the problem of triple-responsive nano-hydrogel synthesis optimization or few reports and short response time slow, poor mechanical properties, etc., to achieve good temperature/pH sensitivity, high encapsulation efficiency, and regular structure

Inactive Publication Date: 2019-05-14
JINLING INST OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, traditional hydrogels suffer from poor mechanical properties and slow or delayed response times to external stimuli.
[0005] Currently, there are few studies or reports on the synthesis optimization of magnetic / pH / temperature triple-responsive nanohydrogels

Method used

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  • Magnetism/temperature/pH tri-responsive nanogel and preparation method thereof
  • Magnetism/temperature/pH tri-responsive nanogel and preparation method thereof
  • Magnetism/temperature/pH tri-responsive nanogel and preparation method thereof

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Experimental program
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Effect test

Embodiment 1

[0058] First, Fe is prepared by chemical modification co-precipitation method 3 O 4 As for the nanoparticles, weigh 0.129g NIPAM, 0.009gPAA and 0.042g SDS and dissolve in 40ml distilled water, and record it as water phase 7. Weigh out 0.0857g MAPEG and 0.03175g DVB and dissolve them in 3ml DMSO, and record it as oil phase 8. Weigh 0.1g Fe 3 O 4 Dissolved in cyclohexane (the concentration of magnetic fluid is 5%), denoted as oil phase 9. The oil phase 8 was added dropwise to the water phase 7 with a peristaltic pump (mechanical stirring, 800 rpm, 2.5 ml / h), and ordinary ultrasound for 1.5 h. Afterwards, the oil phase 9 was added dropwise to the water phase 7 with a peristaltic pump (mechanical stirring, 800 rpm, 2.5 ml / h), and ordinary ultrasound for 1.5 h. Then cover the bottom of the 2000mL large beaker with physiological ice cubes, put the above emulsion into the 250mL small beaker and place it in the large beaker, cushion it with soft foam around it, clean the probe of the ...

Embodiment 2

[0061] First, Fe is prepared by chemical modification co-precipitation method 3 O 4 As for the nanoparticles, weigh 0.129g NIPAM, 0.009g PAA and 0.045g SDS and dissolve in 45ml distilled water, and record it as water phase 13. Weigh out 0.0923g MAPEG and 0.0456g DVB and dissolve in 4ml DMSO, and record it as oil phase 14. Weigh 0.2g Fe 3 O 4 Dissolved in cyclohexane (the concentration of magnetic fluid is 10%), denoted as oil phase 15. The oil phase 14 was added dropwise to the water phase 13 with a peristaltic pump (mechanical stirring, 900 rpm, 3 ml / h), and ordinary ultrasonic for 2 h. After that, the oil phase 15 was added dropwise to the water phase 13 with a peristaltic pump (mechanical stirring, 900 rpm, 3 ml / h), and ordinary ultrasound was performed for 2 hours. Then cover the bottom of the 2000mL large beaker with physiological ice cubes, put the above emulsion into the 250mL small beaker and place it in the large beaker, cushion it with soft foam around it, clean the ...

Embodiment 3

[0064] First, Fe is prepared by chemical modification co-precipitation method 3 O 4 Nanoparticles, weighed out 0.129g NIPAM, 0.009g PAA and 0.04g SDS dissolved in 50ml of distilled water, denoted as water phase 19. Weigh 0.08g of MAPEG and 0.0198g of DVB in 5ml of DMSO, and record it as oil phase 20. Weigh 0.3g Fe 3 O 4 It is dissolved in cyclohexane (the concentration of magnetic fluid is 15%), and it is recorded as oil phase 21. The oil phase 20 was added dropwise to the water phase 19 with a peristaltic pump (mechanical stirring, 1000 rpm, 3.5 ml / h), and ordinary ultrasound for 2.5 h. After that, the oil phase 21 was added dropwise to the water phase 19 (mechanical stirring, 1000 rpm, 3.5 ml / h) with a peristaltic pump, and ordinary ultrasound was performed for 2.5 hours. Then cover the bottom of the 2000mL large beaker with physiological ice cubes, put the above emulsion into the 250mL small beaker and place it in the large beaker, cushion it with soft foam around it, clean...

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Abstract

The invention discloses a magnetism/temperature/pH tri-responsive nanogel medicine carrying system capable of carrying combined chemotherapy drug of the breast cancer, namely paclitaxel, and disclosesa preparation method of magnetic nanogel. The preparation method comprises the steps that Fe3O4 nano particles are prepared by adopting a chemically modified coprecipitation method, polyacrylic acid(PAA) and N-isopropylacrylamide (NIPAM) are taken as monomers, divinylbenzene (DVB) is taken as a cross-linking agent, Fe3O4 is taken as a nuclear body material, and the magnetic nanogel is prepared by adopting a miniemulsion co-polymerization method. The preparation method of the magnetic nanogel has the advantages that the magnetic nanogel loaded with the paclitaxel is synthesized through the miniemulsion polymerization method, the operation is simple, the experiment conditions are mild, and the synthesized nanogel is regular in appearance and uniform in dispersion, and has good temperaturesensibility and pH-sensitivity. Test results show that drug encapsulation efficiency is high, and the slow-release time is as long as 14 days.

Description

Technical field [0001] The invention relates to the application research of nano materials, in particular to a triple responsive nano hydrogel loaded with paclitaxel and a preparation method thereof. Background technique [0002] With the increasing incidence of malignant tumors and other difficult diseases, coupled with the development of technology, patients have a higher pursuit of health and longevity, and doctors have more technical requirements for diagnosis and treatment. Faced with such a severe reality, cancer treatment urgently needs to make breakthroughs as soon as possible. All of these urgently require scientists to find more efficient treatment options to improve the survival rate of patients. The hydrogel drug-carrying system can respond to changes in a certain external stimulus signal (temperature, pH, ionic strength, but also light, magnetic field, specific chemical or biological substances, etc.). According to the nature and strength of the stimulus signal Weak...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/06A61K47/02A61K47/32A61K31/337A61P35/00
Inventor 张小娟郝凌云乔梦娜戴红艳顾月皓盛丹丹刘姣杨亚婷余彤孔景阳
Owner JINLING INST OF TECH
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