Preparation method for antibacterial chitosan and application of antibacterial chitosan serving as wound care ointment
A wound care and antibacterial shell technology, applied in the directions of ointment delivery, medical preparations containing active ingredients, pharmaceutical formulations, etc., can solve the problems of poor biocompatibility and degradability, complex product structure, difficult to enlarge, etc. Good property, simple preparation process, and the effect of accelerating wound healing
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Embodiment 1
[0027] A kind of preparation method of antibacterial chitosan, comprises the steps:
[0028] 1) Stir and dissolve 50 mL of chitosan acetate aqueous solution with a mass fraction of 3%;
[0029] 2) Add 1.5 g of N,N-dimethyldecylamine to the solution in the previous step, then add 2 g of methyl iodide and 1 g of epichlorohydrin, and stir at 80 °C for 30 h;
[0030] 3) After the reaction, wash with absolute ethanol and n-hexane alternately three times, and vacuum dry to obtain antibacterial chitosan;
[0031] Utilize above-mentioned antibacterial chitosan to prepare the preparation method of antibacterial chitosan wound care ointment, comprise the steps:
[0032] Dissolve 1 g of antibacterial chitosan in 45 mL of deionized water, add 2 g of glycerin and 1 g of rhubarb extract, and stir mechanically at 60 °C for 1 h; weigh 40 g of petroleum jelly, and stir mechanically at 60 °C for 1 h. After cooling and filling, the antibacterial chitosan wound care ointment can be obtained.
Embodiment 2
[0034] A kind of preparation method of antibacterial chitosan, comprises the steps:
[0035] 1) Stir and dissolve 50 mL of chitosan acetate aqueous solution with a mass fraction of 5%;
[0036] 2) Add 2.5 g of N,N-dimethyldodecylamine to the solution in the previous step, then add 1.5 g of 1,6-dibromohexane, and stir at 80 °C for 25 h;
[0037] 3) After the reaction, wash twice with ethanol and acetone respectively, and dry in vacuum to obtain antibacterial chitosan;
[0038] Utilize above-mentioned antibacterial chitosan to prepare the preparation method of antibacterial chitosan wound care ointment, comprise the steps:
[0039] Dissolve 1 g of antibacterial chitosan in 45 mL of deionized water, add 2 g of glycerin, 1 g of Galla gall extract and 1 g of Calendula officinalis extract, and stir mechanically at 70 °C for 1 h; weigh 40 g of petroleum jelly, 80 °C mechanically stirred for 1 h. After cooling and filling, the antibacterial chitosan wound care ointment can be obtai...
Embodiment 3
[0041] A kind of preparation method of antibacterial chitosan, comprises the steps:
[0042] 1) Stir and dissolve 300 mL of chitosan lactate aqueous solution with a mass fraction of 1%;
[0043] 2) Add 2.5 g of N,N-dimethyldodecylamine and N,N-dimethyltetradecamine to the solution in the previous step, and then add 1 g of 1,6-bromohexane and 4 g of 1,2- Dibromoethane, stirred at 90 °C for 72 h;
[0044] 3) After the reaction, wash twice with methanol, n-hexane, and ethanol in sequence, and blow dry to obtain antibacterial chitosan;
[0045]Utilize above-mentioned antibacterial chitosan to prepare the preparation method of antibacterial chitosan wound care ointment, with embodiment 1.
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