A kind of modified clinoptilolite and its preparation method and application

A clinoptilolite and modification technology, which is applied in the field of modified clinoptilolite and its preparation, can solve the problems of many influencing factors, missing the best time, and the decline of effect of promotion and absorption absorption, so as to increase specific surface area, increase Na+ exchange amount, effect of improving alkali modification effect

Active Publication Date: 2022-06-28
中国人民解放军海军特色医学中心
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, most of the existing excretion-stimulating and absorption-absorbing drugs are only effective for a single radionuclide, and some have certain side effects
However, radionuclide pollution events in the body are often complicated and have many influencing factors. It is still difficult to quickly determine the type of radionuclide that caused the pollution. The best time for drug absorption has been missed, and the effect of promoting excretion and preventing absorption has been greatly reduced

Method used

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  • A kind of modified clinoptilolite and its preparation method and application
  • A kind of modified clinoptilolite and its preparation method and application
  • A kind of modified clinoptilolite and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] The preparation of embodiment 1 modified clinoptilolite

[0042] The natural clinoptilolite (origin: Chaoyang, Liaoning) was pulverized and washed with pure water until there was no suspended powder, rinsed twice with water, and dried at 120°C to obtain the original ore sample. Weigh 30 g of clinoptilolite raw ore sample, heat it in a muffle furnace at 450 °C for 4 hours, cool it naturally, add it to 300 mL of 2 mol / L NaOH solution, stir and heat it at 80 °C for 24 hours, remove the supernatant, Rinse repeatedly with pure water until neutral, dry at 120°C for 2 hours, screen with a 400-mesh sieve, and store in a sealed container.

Embodiment 2

[0043] Example 2 Characterization of modified clinoptilolite

[0044] The modified clinoptilolite prepared in Example 1 was detected as follows:

[0045] In order to observe the microstructure of modified clinoptilolite, the scanning electron microscope was used to observe, and the results are as follows figure 1 As shown, it can be seen that the clinoptilolite has a porous structure.

[0046] The chemical analysis results of the modified clinoptilolite minerals are shown in Table 1. It can be seen from Table 1 that the ratio of silicon to aluminum in the modified clinoptilolite is n(Si / Al)=2.79, the Na content is higher than 4 wt%, and the Ca content is higher than 3.5 wt%.

[0047] Table 1 Chemical composition of modified clinoptilolite

[0048] composition Content (wt%) SiO 2

59.5061 Al 2 O 3

21.3511 CaO 5.8771 Na 2 O

5.4460 Fe 2 O 3

3.8495 K 2 O

1.7465 MgO 0.8628 SrO 0.8024 TiO 2 ...

Embodiment 3

[0054] Example 3 The saturated adsorption capacity of modified clinoptilolite to nuclides in aqueous solution

[0055] Take by weighing the modified clinoptilolite and natural clinoptilolite (origin: Chaoyang, Liaoning, with embodiment 1) prepared by 0.1g embodiment 1 respectively, by solid-liquid ratio 1:200, add to the Mn that concentration is 1000mg / L respectively 2+ , Ni 2+ , Co 2+ , Sr 2+ and Cs + In the water sample, placed in a constant temperature shaker, at 30 °C, static adsorption was carried out for different times, the sample was centrifuged at 5000 rpm, the supernatant was taken, and Mn was detected by ICP 2+ , Ni 2+ , Co 2+ , Sr 2+ and Cs + concentration, and calculate the adsorption capacity of clinoptilolite according to formula (1).

[0056] q=V(C 0 -C t ) / m (1)

[0057] In the formula: q—adsorption capacity, mg / g;

[0058] m—mass of modified zeolite, g;

[0059] C 0 —Initial ion mass concentration, mg / L;

[0060] C t - mass concentration of re...

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Abstract

A modified clinoptilolite and its preparation method and application. The modified clinoptilolite is prepared by the following steps: pulverizing the natural clinoptilolite, washing with water, and drying; drying the dried clinoptilolite at 450-600°C React at low temperature for 2‑4h, and cool naturally; add the high-temperature-treated clinoptilolite powder into 1‑2mol / L NaOH solution, and control the solid-liquid ratio to 1:10~20, g / mL; at 80‑100°C After stirring and heating for 8-24 hours, remove the supernatant, rinse repeatedly with pure water to neutrality, and dry; pass through a mesh screen of more than 400 mesh to obtain modified clinoptilolite. The silicon-aluminum ratio of the modified clinoptilolite n(Si / Al)=2.7-5.0, the Na content is higher than 4wt%, the Ca content is higher than 3.5wt%, the particle size is less than or equal to 400 mesh, and it is resistant to radioactive cesium, strontium, cobalt, Manganese, nickel, etc. have large adsorption capacity, and can be used to prepare drugs for promoting excretion of radionuclide pollution in vivo.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a modified clinoptilolite and a preparation method and application thereof, in particular to a modified clinoptilolite and a preparation method thereof and its application in the preparation of radionuclide pollution-promoting drugs in vivo . Background technique [0002] Internal contamination of radionuclides refers to the entry of non-natural radionuclides into the body through the respiratory tract, gastrointestinal tract, skin or wound, or the content of radionuclides in the body exceeds the natural amount. The radionuclides deposited in the body constitute an internal exposure source, which will cause continuous exposure to the human body, thereby causing damage of internal exposure, including damage to tissues or organs, internal radiation sickness and internal exposure-induced tumors. . The physical and chemical properties of radionuclides are different, an...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C01B39/02C01B33/26B01J20/18B01J20/30A61K33/06A61P39/02
Inventor 罗群蒋定文侯登勇何颖
Owner 中国人民解放军海军特色医学中心
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