A kind of ionic viologen compound and its photodynamic therapy application

Abstract

The invention discloses an ionic viologen compound and its application, belonging to the technical field of photodynamic therapy. The present invention designs and synthesizes a new class of cationic viologen compounds based on 4,4'-bipyridine, which has the following advantages: 1. The cationic skeleton endows it with cationic characteristics, such as good hydrophilicity, can Effectively combine with negatively charged bacteria; 2. The introduction of oxygen group elements into the viologen skeleton improves the absorption of molecules in the visible light region, and also promotes the production of active oxygen species; 3. Easy to ion, can be added by adding active groups The group enhances the therapeutic effect of the molecule and has low biological toxicity; 4. It has good biocompatibility. The present invention proves through experiments that the above-mentioned compound has significant inhibitory activity on Gram-negative bacteria and Gram-positive bacteria, and thus has the potential of being a photosensitizer for effective photodynamic therapy.

Description

technical field [0001] The invention belongs to the technical field of photodynamic therapy, and in particular relates to an ionic viologen compound and its application in photodynamic therapy. Background technique [0002] Bacteria threaten the health of humans and the survival of flora and fauna in the surrounding environment. Therefore, the application of antibacterial agents is of great significance. However, long-term repeated use of the same fungicide has resulted in strong resistance of pathogenic bacteria to many current fungicides. In addition, many countries have banned the use of some fungicides that have adverse effects on the environment, humans or ecology. Therefore, it is of great significance to research and develop new sterilization methods with high efficiency, low toxicity and environmental protection. [0003] Photodynamic therapy (Photodynamic Therapy, PDT) is a new physical and chemical treatment technology developed in recent years. As an effective ...

AI Technical Summary

Problems solved by technology

[0004] Currently used small molecule organic photosensitizers, such as porphyrin, methylene blue, BODIPY, etc. are hydrophobic molecules, easy to aggregate, difficult to deliver to tumor sites in vivo, lack of targeting to tumor tissue, difficult to enrich and reach effective concentrations, and affect treatment Effect

In addition, its extinction coefficient is low, and its selectivity to healthy tissues is poor, which easily destroys normal cells and affects the effect of treatment.

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