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Biomaterial modified with hydrophilic lubrication coating on surface and preparation method of biomaterial

A technology of lubricating coatings and biomaterials, applied in the direction of coatings, etc., can solve problems such as high requirements for solution rheological properties, inability to lubricate modification, complicated preparation process, etc.

Active Publication Date: 2019-06-21
YANTAI ZHONGKE RES INST OF ADVANCED MATERIALS & GREEN CHEM ENG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] However, no matter for single-layer coating technology or double-layer coating technology, the preparation process is very complicated and requires expensive UV curing molding equipment; in addition, the coating process has high requirements on the rheological properties of the solution, and the precursor The viscosity, wettability, leveling and defoaming properties of the solution need to be strictly formulated and controlled; furthermore, the existing photocuring coating technology cannot be used to make the lumen, concave hole or complex structure of opaque medical device materials hydrophilic Lubricating Modification

Method used

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  • Biomaterial modified with hydrophilic lubrication coating on surface and preparation method of biomaterial
  • Biomaterial modified with hydrophilic lubrication coating on surface and preparation method of biomaterial
  • Biomaterial modified with hydrophilic lubrication coating on surface and preparation method of biomaterial

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preparation example Construction

[0018] The invention provides a method for preparing a biomaterial whose surface is modified with a hydrophilic lubricating coating, comprising the following steps:

[0019] Mix vinyl active monomer, dopamine hydrochloride and tris buffer to form a precursor solution;

[0020] The biological base material to be modified is immersed in the precursor solution to carry out polymerization reaction, and the biological material with a hydrophilic lubricating coating on the surface is obtained.

[0021] The invention mixes vinyl active monomers, dopamine hydrochloride and tris buffer to form a precursor solution. In the present invention, the vinyl reactive monomer preferably includes acrylamide (AAm), N-isopropylacrylamide (NIPAAm), hydroxyethyl methacrylate (HEMA), ethylene glycol methacrylate (OEGMA ), polyoxyethylene methacrylate (PEGMA), acrylic acid (AA), sodium methacrylic acid (MAA), methacryloyloxyethyl dimethyl ammonium chloride (METAC), methacrylic acid N,N - Dimethylami...

Embodiment 1

[0033] Hydrophilic coating for PVC catheter surface modification:

[0034] (1) Weigh 100 mg of dopamine hydrochloride and 500 mg of methacryloyloxyethyl phosphorylcholine (MPC) and dissolve them in 100 mL of Tris buffer solution (10 mM, pH=8.5), stir rapidly until the solid is completely dissolved to obtain the precursor body solution;

[0035] (2) Immerse the medical PVC urinary catheter into the above precursor solution, take it out after reacting at room temperature for 10 hours, wash it with ethanol and secondary deionized water, and dry it in an oven to obtain the surface-modified polydopamine hydrochloride-polymethacryl Oxyethylphosphorylcholine (PDA-PMPC) coated PVC catheter.

[0036] The photo of the PVC urinary catheter of the PDA-PMPC coating that the present embodiment obtains is modified is as figure 1 shown.

[0037] Characterization of coating physical and chemical properties:

[0038] (1) Characterization of coating thickness: measured by ellipsometer and at...

Embodiment 2

[0043] Hydrophilic coating on the surface of PDMS sheet:

[0044] (1) Weigh 100mg of dopamine hydrochloride and 1000mg of 3-sulfopropyl methacrylate potassium salt (SPMA) and dissolve them in 100mL of Tris buffer solution (10mM, pH=8.5), stir rapidly until the solid is completely dissolved to obtain the precursor solution;

[0045] (2) Immerse the polydimethoxysiloxane (PDMS) sheet in the above precursor solution, take it out after 20 hours of reaction at room temperature, rinse with ethanol and secondary deionized water, and dry in an oven, that is, on the surface of the PDMS sheet The polydopamine hydrochloride-polymethacrylate 3-sulfonate propyl potassium salt (PDA-PSPMA) coating was successfully modified.

[0046] Characterization of coating physical and chemical properties:

[0047] (1) Characterization of coating thickness: measured by ellipsometer and atomic force microscope, the thickness of PDA-PSPMA coating is 35nm.

[0048] (2) Characterization of wettability: ch...

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Abstract

The invention provides a biomaterial modified with a hydrophilic lubrication coating on the surface and a preparation method of the biomaterial and belongs to the technical field of surface and interface modification of biological medical device materials. The preparation method comprises the following materials: mixing a vinyl active monomer, dopamine hydrochloride and a tris buffer solution to form a precursor solution; immersing a to-be-modified biological base material into the precursor solution for performing polymerization reaction. The dopamine in the biomaterial disclosed by the invention is subjected to oxidation self-crosslinking polymerization under the aerobic condition; meanwhile, the dopamine produces free radical in the oxidation self-crosslinking process; the generated free radical initiates free radical polymerization of the vinyl active monomer on the surface of the biological base material to form a coating; as wet adhesion effect of the dopamine enables the coatingto be well adhered to the surface of the biological base material, a binding force of the coating and the biological base material is better; means such as ultraviolet or heating is not needed in theprocess, so that the cost is low; as polyvinyl active monomer contains a large amount of hydrophilic groups, the biomaterial shows stable water lubrication performance.

Description

technical field [0001] The invention relates to the technical field of surface and interface modification of biomedical device materials, in particular to a biological material with a hydrophilic lubricating coating on the surface and a preparation method thereof. Background technique [0002] With the development of high-end biomaterials and medical devices, higher requirements are placed on the functionality of the surface of implant materials. For example, histocompatibility, antibacterial, anticoagulant and biodegradability etc. Among them, for interventional medical materials, low surface friction is one of the important indicators. For example, when auxiliary devices such as gastric tubes, guide wires, and urinary catheters are inserted into and removed from the human body, they must ensure excellent water-lubricating properties on the surface of the devices to reduce the pain of patients. Therefore, in order to improve the water lubricity of the surface of implantab...

Claims

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Application Information

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IPC IPC(8): C08J7/04C09D179/04C09D133/14A61L29/08C08L83/04C08L27/18
Inventor 周峰麻拴红魏强斌
Owner YANTAI ZHONGKE RES INST OF ADVANCED MATERIALS & GREEN CHEM ENG
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