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Preparation method of plant molluscacide, namely thiamine disulfide

A molluscicide and molluscicide technology, which is applied in the synthesis field of known compounds, can solve problems such as not going deep into the process, and achieve the effects of operability of the process, convenient product separation and simple reaction process.

Active Publication Date: 2019-06-28
HEFEI UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Unfortunately, the scholar only produced tea saponin with a purity of 87.58% in a relatively mild environment and in a short period of time, and did not go deep into the process of preparing snails from tea saponin

Method used

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  • Preparation method of plant molluscacide, namely thiamine disulfide
  • Preparation method of plant molluscacide, namely thiamine disulfide
  • Preparation method of plant molluscacide, namely thiamine disulfide

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0054] 1. Hydrolysis and calcification of camellia saponin

[0055] Take by weighing 1.1g of calcium hydroxide in a three-necked flask, add 75ml of deionized water, stir evenly, then weigh 8.3g of tea saponin (mass fraction is 60%, containing 5g of tea saponin), stir and mix evenly, and It was heated to 40° C., stirred with a stirrer, and reacted stably for 12 hours to obtain khaki-colored calcium saponin, which was washed 1 to 2 times with a small amount of deionized water. After suction filtration with a vacuum pump, put the saponin calcium into a vacuum drying oven at 50-75° C. for 12 hours to obtain 6.4 g of dry saponin calcium with a yield of 77.1%.

[0056] 2. Acidified snailcarb solution of saponin calcium

[0057] The saponin calcium solid obtained in the previous step is dispersed with 100mL deionized water, and stirred with a magnetic stirrer, and at room temperature, it is 10% sulfuric acid that the mass fraction is added dropwise with a separatory funnel, and the ...

Embodiment 2

[0061] 1. Hydrolysis and calcification of camellia saponin

[0062] Take by weighing 1.1g of calcium hydroxide in a three-necked flask, add 75ml of deionized water, stir evenly with water, then weigh 8.3g of Camellia saponin (60% by mass fraction, containing 5g of Camellia saponin) and mix uniformly, then heat it Stable reaction at 50°C for 12 hours to obtain khaki-colored calcium saponin, which was washed 1-2 times with a small amount of deionized water. After filtering with a vacuum pump, put the calcium saponin into a vacuum drying oven at 50-75° C. for 12 hours to obtain 7.1 g of dry calcium saponin with a yield of 85.5%.

[0063] 2. Acidified snailcarb solution of saponin calcium

[0064] According to the operation steps in Example 1, the saponin obtained in the previous step was acidified to obtain the spirovil solution.

[0065] 3. Refined by Luowei

[0066] According to the operation steps in Example 1, the conflucarb solution was treated to obtain 3.8 g of confluca...

Embodiment 3

[0068] Take by weighing 1.1g of calcium hydroxide in a three-necked flask, add 75ml of deionized water, stir evenly, then weigh 8.3g of tea saponin (mass fraction is 60%, containing 5g of tea saponin), stir and mix evenly, and It was heated to 90°C. Use a stirrer to stir and react stably for 12 hours. Saponin calcium precipitation cannot be obtained. The reaction solution turns black and has a foul smell. The Molish experiment and Libermann Burchard experiment are carried out on the reaction solution. It is found that there is no characteristic color, which can be judged at a temperature of 90 ° C. Under reaction 12h can cause camellia saponin to go bad.

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Abstract

The invention discloses a preparation method of a plant molluscacide, namely thiamine disulfide. The method comprises the steps of with camellia saponin as a raw material, hydrolyzing the camellia saponin by virtue of Ca(OH), forming soluble calcium salt by virtue of 2-methyl-2-butenoic acid and acetic acid which are generated during the hydrolysis as well as Ca<2+>, generating insoluble calcium salt saponin decarboxylated calcium precipitates by virtue of partial carboxyl of glycosyl of the camellia saponin and Ca<2+>, filtering, dispersing the insoluble saponin decarboxylated calcium precipitates by virtue of deionized water, acidizing calcium salt by virtue of sulfuric acid, filtering to remove CaSO4 precipitates, and carrying out reduced pressure distillation by virtue of the filtrate,so as to obtain thiamine disulfide H2B. According to the preparation method, high-quality thiamine disulfide is prepared from tea saponin, and the surplus camellia saponin is changed from the waste into wealth, so that the preparation method can be applied to the industrial production, and the technical support is provided for the popularization of thiamine disulfide.

Description

technical field [0001] The present invention relates to a synthesis method of a known compound, in particular to a preparation method of the plant molluscicide spiricarb, which uses camellia saponin as a raw material to obtain the plant molluscicide snailcarb through ester hydrolysis and separation . Background technique [0002] Schistosomiasis is one of the most serious parasitic diseases that endanger human health. Schistosomiasis is prevalent in more than 70 countries and regions around the world, affecting about 3.1 billion people, and more than 200 million people are infected and die of this disease every year. millions [1-2] . The practice of schistosomiasis control shows that snails are the only intermediate host of schistosomiasis, and controlling snails can effectively control the spread of schistosomiasis. Therefore, in schistosomiasis-prone areas, killing molluscs is one of the direct and effective measures to prevent schistosomiasis infection. [0003] After ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07J63/00
Inventor 冯乙巳方耀浦同俊方满娣贾树寅朱旭于竞超
Owner HEFEI UNIV OF TECH
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