Compound tetracaine hydrochloride membrane and preparation method thereof

A tetracaine hydrochloride film and the technology of tetracaine hydrochloride are applied in the directions of pharmaceutical formulations, medical preparations with inactive ingredients, medical preparations containing active ingredients, etc. The effect of uniform texture and improved production efficiency

Inactive Publication Date: 2019-07-02
HARBIN MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Because of its recurrent character...

Method used

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  • Compound tetracaine hydrochloride membrane and preparation method thereof
  • Compound tetracaine hydrochloride membrane and preparation method thereof
  • Compound tetracaine hydrochloride membrane and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] The preparation of embodiment 1 compound tetracaine hydrochloride film

[0028] Include the following steps:

[0029] (1) Take tetracaine hydrochloride, gentamycin sulfate, hydrocortisone, carboxymethylcellulose sodium (CMC-Na), polyvinyl alcohol (PVA), glycerol respectively according to the parts by weight described below and purified water:

[0030] 0.4 parts by weight of tetracaine hydrochloride, 0.2 parts by weight of gentamicin sulfate, 0.2 parts by weight of hydrocortisone, 1.6 parts by weight of sodium carboxymethylcellulose (CMC-Na), 8 parts by weight of polyvinyl alcohol (PVA), 4 parts by weight of glycerin, 80 parts by weight of purified water.

[0031] (2) Add the weighed carboxymethylcellulose sodium (CMC-Na) and polyvinyl alcohol (PVA), add appropriate amount of purified water to soak and swell fully, heat and dissolve on a water bath at 85-90°C, avoid stirring, and make it Naturally dissolve completely to obtain film slurry, cool for later use;

[0032...

Embodiment 2

[0035] The preparation of embodiment 2 compound tetracaine hydrochloride film

[0036] Include the following steps:

[0037] (1) Take tetracaine hydrochloride, gentamycin sulfate, hydrocortisone, carboxymethylcellulose sodium (CMC-Na), polyvinyl alcohol (PVA), glycerol respectively according to the parts by weight described below and purified water:

[0038] 0.5 parts by weight of tetracaine hydrochloride, 0.2 parts by weight of gentamicin sulfate, 0.1 parts by weight of hydrocortisone, 1 part by weight of sodium carboxymethylcellulose (CMC-Na), 15 parts by weight of polyvinyl alcohol (PVA), 12 parts by weight of glycerin, and 90 parts by weight of purified water.

[0039] (2) Add the weighed carboxymethylcellulose sodium (CMC-Na) and polyvinyl alcohol (PVA), add appropriate amount of purified water to soak and swell fully, heat and dissolve on a water bath at 85-90°C, avoid stirring, and make it Naturally dissolve completely to obtain film slurry, cool for later use;

[0...

Embodiment 3

[0043] The preparation of embodiment 3 compound tetracaine hydrochloride film

[0044] Include the following steps:

[0045] (1) Take tetracaine hydrochloride, gentamycin sulfate, hydrocortisone, carboxymethylcellulose sodium (CMC-Na), polyvinyl alcohol (PVA), glycerol respectively according to the parts by weight described below and purified water:

[0046] 0.3 parts by weight of tetracaine hydrochloride, 0.3 parts by weight of gentamycin sulfate, 0.3 parts by weight of hydrocortisone, 2 parts by weight of sodium carboxymethylcellulose (CMC-Na), 5 parts by weight of polyvinyl alcohol (PVA), 4 parts by weight of glycerin, 70 parts by weight of purified water.

[0047] (2) Add the weighed carboxymethylcellulose sodium (CMC-Na) and polyvinyl alcohol (PVA), add appropriate amount of purified water to soak and swell fully, heat and dissolve on a water bath at 85-90°C, avoid stirring, and make it Naturally dissolve completely to obtain film slurry, cool for later use;

[0048] ...

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Abstract

The invention discloses a compound tetracaine hydrochloride membrane and a preparation method thereof. The compound tetracaine hydrochloride membrane is prepared from tetracaine hydrochloride, gentamicin sulfate, hydrocortisone, sodium carboxymethylcellulose (CMC-Na), polyvinyl alcohol (PVA), glycerol and purified water. When a drug is added to a film-forming material, an FLUKO FA25 high-shear dispersing emulsifying machine is used for stirring, and compared with traditional manual stirring, a medicine liquid is uniform and fine in quality, and the working efficiency is high. In a membrane laying process, an electric membrane laying device is used to replace an original manual membrane laying manner, thus solving the conditions that the production efficiency is low, the thickness of a medical membrane is not uniform, a weight difference limit degree in quality inspection is not in conformity with regulations, and the like. The electric membrane laying device is simple and easy to operate, can accurately control the membrane laying rate and the thickness of films, is uniform in membrane laying, is good in flatness, is controllable in thickness, and enables the production efficiencyto be greatly improved. The compound tetracaine hydrochloride membrane is locally applied to treat oral ulcer, has the effects of diminishing inflammation and stopping pain, is strong in pertinence, is substantial in curative effect, is easy for patients to accept, and is an ideal medicine for treating the oral ulcer.

Description

technical field [0001] The invention relates to a compound tetracaine hydrochloride film and a preparation method thereof. The invention belongs to the technical field of medicine production. Background technique [0002] Recurrent oral ulcer (ROU) is a common oral mucosal disease. The ulcer site is painful at the onset and lasts for a long time. Because of its recurrent nature, it brings great misery to patients. ROU may be related to factors such as local trauma, stress, diet, drugs, hormones, and vitamin and trace element deficiency, and the main cause of the disease is still being studied. [0003] Films are film-like dosage forms made by dissolving or uniformly dispersing drugs in film-forming materials, which can be used for oral or mucosal application. Oral films (OFs), also known as orodispersible films (Oradispersible films), oral instant films (Oral Fast dissolving Films, Fast dissolving films, Oral dissolvable films, Orally dissolving strips), are characterized...

Claims

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Application Information

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IPC IPC(8): A61K31/245A61K31/7036A61K31/573A61K9/70A61K47/38A61P1/02
CPCA61K9/006A61K9/7007A61K31/245A61K31/573A61K31/7036A61K47/38A61P1/02A61K2300/00
Inventor 陈岩刘亮曲婷王智勇
Owner HARBIN MEDICAL UNIVERSITY
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