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Drug-loading particle and preparation method thereof

A particle and drug-carrying technology, applied in the field of pesticide chemistry, can solve the problems of large amount of organic solvents, environmental pollution, etc., achieve good biological activity and improve the effect of drug utilization

Active Publication Date: 2019-07-05
INST OF PLANT PROTECTION CHINESE ACAD OF AGRI SCI +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the drug-loaded particles obtained by using high-molecular organic polymers as carriers have a "burst release" phenomenon during the release process, and high-molecular organic polymers use a large amount of organic solvents during the preparation process, which is likely to cause environmental pollution

Method used

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  • Drug-loading particle and preparation method thereof
  • Drug-loading particle and preparation method thereof
  • Drug-loading particle and preparation method thereof

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preparation example Construction

[0034] In the present invention, the metal-organic framework material is preferably Fe-MIL-100, and the present invention has no special requirements on the source of the Fe-MIL-100, which can be commercially available or self-made. In the present invention, the preparation method of the Fe-MIL-100 preferably comprises the following steps:

[0035] Iron powder, trimesic acid, hydrofluoric acid, concentrated nitric acid and water are mixed, and a hydrothermal reaction is carried out under airtight conditions to obtain Fe-MIL-100; the temperature of the hydrothermal reaction is preferably 150-180°C, preferably The temperature is preferably 150°C, and the time is 10 to 15 hours, more preferably 12 hours. The present invention has no special requirements on the heating rate of the hydrothermal reaction.

[0036] In the present invention, the mass ratio of the iron powder to trimesic acid is preferably 250-280:600-750, more preferably 277.5:687.5; the mass concentration of the hyd...

Embodiment 1

[0051] 200 μL of hydrofluoric acid with a mass concentration of 35% and 190 μL of concentrated nitric acid with a mass concentration of 65% were added to 20 mL of ultrapure water to form a mixed solution. Then 277.5 mg of iron powder and 687.5 mg of trimesic acid were weighed and placed in the above mixed solution to obtain the reaction raw materials. The reaction raw materials were transferred to a reaction kettle, placed in an oven, and heated to 150° C. for 12 hours. After the reaction, cool to room temperature, collect the solid product by filtration, wash with ultrapure water three times, then wash the product in hot water at 80°C for 5h, and then wash in ethanol at 60°C for another 3h to remove unreacted raw materials. Cool to room temperature after the reaction, centrifuge at 1000rpm for 10min to collect the high-purity product, and finally vacuum-dry at 80°C for 12h to obtain Fe-MIL-100.

[0052] Take 900mg of azoxystrobin original drug (abbreviated as AZOX), dissolve...

Embodiment 2

[0054] The test was carried out according to the method of Example 1, with the difference that the mass ratio of azoxystrobin original drug and Fe-MIL-100 was controlled to 2:1 to obtain drug-loaded particles AZOX@Fe-MIL-100.

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Abstract

The invention provides a drug-carrying particle and a preparation method thereof, and relates to the field of chemical pesticides. The drug-carrying particle takes a metal organic framework to load pesticide azoxystrobin, and thus loading and controlled releasing of the metal organic framework to azoxystrobin are achieved. The dug-loading rate of drug-loaded particle to azoxystrobin is high and can reach 16.24%; the drug-loaded particle can be release slowly in acidic, alkaline and neutral environments, the drug utilization rate is effectively improved, and the impact of drug loss on the environment is lowered; the drug-loaded particle is good in biological activity and the biological activity of Chinese herbal medicinal ingredient azoxystrobin in the drug-loaded particle cannot be affected; the drug-loaded particle can be transported in mycelium, the drug ingredients in the drug-loaded particle can make full contact with the mycelium conveniently, and then the drug effect is played.

Description

technical field [0001] The invention relates to the field of pesticide chemistry, in particular to a drug-loaded particle and a preparation method thereof. Background technique [0002] The widespread use of chemical pesticides in agricultural production has effectively controlled pests and diseases and made great contributions to food security. For example, azoxystrobin (AZOX) is a methoxyacrylate (Strobilurin) fungicide, which has the advantages of broad spectrum, high efficiency, low toxicity, stability, long duration, and environmental friendliness. For almost all fungal diseases (Ascomycotina, Basidiomycotina, Flagellate and Deuteromycotina) diseases such as powdery mildew, rust, glume blight, net spot, downy mildew, rice blast, etc. All have good activity. However, due to the low utilization rate of pesticides and the loss of pesticides, it not only causes waste of resources, but also increases the burden on the environment. [0003] Currently, it is an emerging tec...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01N43/54A01N25/10A01N25/12A01P3/00
CPCA01N25/10A01N25/12A01N43/54
Inventor 曹立冬黄啟良单永潘赵鹏跃曹冲李凤敏郑永权
Owner INST OF PLANT PROTECTION CHINESE ACAD OF AGRI SCI
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