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Hollow nanorobot and preparation method and application thereof as antioxidant

A hollow nano, antioxidant technology, used in chemical instruments and methods, anti-toxic agents, organic compounds/hydrides/coordination complex catalysts, etc., to achieve the effects of fast diffusion rate, large movement area, and good ROS scavenging ability

Inactive Publication Date: 2019-07-05
INST OF CHEM CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are few reports on the construction of micro-nano motors or nano-robots with the goal of removing ROS.

Method used

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  • Hollow nanorobot and preparation method and application thereof as antioxidant
  • Hollow nanorobot and preparation method and application thereof as antioxidant
  • Hollow nanorobot and preparation method and application thereof as antioxidant

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] 1)SiO2 2 synthesis of balls

[0050] Add 0.3 g of cetyltrimethylammonium bromide and 2 mL of 25 wt % concentrated ammonia water to a mixed solution containing 60 mL of absolute ethanol and 100 mL of deionized water. Then, the mixture was heated to 35°C, and ethyl orthosilicate (2 mL) was added rapidly with vigorous stirring. After stirring at 35°C for 48 hours, the white product was collected by centrifugation at 5000 rpm for 10 minutes and washed three times with ethanol.

[0051] 2) Mesoporous SiO with hollow structure 2 synthesis of balls

[0052] SiO will be made 2 The spheres were dispersed in 200 mL of deionized water by sonication and aged in a water bath at 90°C for 48 hours. After the precipitate was separated by centrifugation, it was washed three times with deionized water. Disperse the precipitate in 160 mL of absolute ethanol again by sonication, add 480 μL of 37% hydrochloric acid solution, and stir at 60 °C for 3 hours to remove cetyltrimethylammoni...

Embodiment 2

[0070] 1)SiO2 2 synthesis of balls

[0071] Add 0.3 g of cetyltrimethylammonium bromide and 2 mL of 25 wt % concentrated ammonia water to a mixed solution containing 30 mL of absolute ethanol and 100 mL of deionized water. Then, the mixture was heated to 30°C, and ethyl orthosilicate (2 mL) was added rapidly with vigorous stirring. After stirring at 35°C for 48 hours, the white product was collected by centrifugation at 5000 rpm for 10 minutes and washed three times with ethanol.

[0072] 2) Mesoporous SiO with hollow structure 2 synthesis of balls

[0073] SiO will be made 2 The spheres were dispersed in 200 mL of deionized water by sonication and aged in a water bath at 90°C for 48 hours. After the precipitate was separated by centrifugation, it was washed three times with deionized water. The precipitate was again dispersed in 160 mL of absolute ethanol by sonication, 500 μL of 37% hydrochloric acid solution was added, and stirred at 60 °C for 4 hours to remove cetylt...

Embodiment 3

[0079] 1)SiO2 2 synthesis of balls

[0080] Add 0.4 g of cetyltrimethylammonium bromide and 3 mL of 25 wt % concentrated ammonia water to a mixed solution containing 50 mL of absolute ethanol and 120 mL of deionized water. Then, the mixture was heated to 30°C, and ethyl orthosilicate (3 mL) was added rapidly with vigorous stirring. After stirring at 45°C for 48 hours, the white product was collected by centrifugation at 5000 rpm for 10 minutes and washed three times with ethanol.

[0081] 2) Mesoporous SiO with hollow structure 2 synthesis of balls

[0082] SiO will be made 2The spheres were dispersed in 200 mL of deionized water by sonication and aged in a water bath at 70°C for 48 hours. After the precipitate was separated by centrifugation, it was washed three times with deionized water. Disperse the precipitate in 160 mL of absolute ethanol again by sonication, add 500 μL of 37% hydrochloric acid solution, and stir at 60 °C for 4 hours to remove hexadecyltrimethylamm...

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Abstract

A hollow nanorobot is nanoenzyme (hemin-HMSNs) mainly composed of hollow mesoporous silica spheres (HMSNs) and hemin loaded on the surface of the hollow mesoporous silica spheres. The hollow nanorobothas the properties of peroxidase (POD) like and superoxide dismutase (SOD) like, and uses H2O2, superoxide radical (O2.<->), hydroxyl radical (.OH) as fuel, the chemical free energy released by catalysis of H2O2, superoxide radical (O2.<->), hydroxyl radical (.OH) by hemin is used as motive force to induce its own movement, and the movement area is larger. The conversion of ROS into non-toxic H2Ocan greatly improve the scavenging efficiency of ROS in cells.

Description

technical field [0001] The invention belongs to the technical field of nano-antioxidant preparation, and in particular relates to a hollow nano-robot, a preparation method thereof and an application as an antioxidant. Background technique [0002] In living systems, overexpressed reactive oxygen species (ROS), such as superoxide anion (O 2 ·- ), hydrogen peroxide (H 2 o 2 ), hydroxyl radicals (·OH), etc., can cause oxidative damage to body tissues. When these injuries are severe, they can also cause a series of diseases, such as inflammation, diabetes, cardiovascular disease, cancer and so on. With the continuous development of nanotechnology, it has been found that many nanomaterials, including metal compounds, noble metals and carbon-based nanomaterials, can scavenge overexpressed active oxygen free radicals in cells for cell protection. In order to achieve good ROS scavenging efficiency, increasing the amount of nanomaterials (nanozymes) used is an effective method, ...

Claims

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Application Information

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IPC IPC(8): B01J31/18B01J35/08A61P39/06
CPCB01J31/183A61P39/06B01J2531/842B01J2531/025B01J35/23B01J35/51
Inventor 王铁陈旭练美玲
Owner INST OF CHEM CHINESE ACAD OF SCI
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