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Application of yeast glucan composition in preventing constipation

A technology of yeast glucan and composition is applied in the application field of yeast glucan composition in preventing constipation, and can solve problems such as side effects and drug resistance.

Pending Publication Date: 2019-07-19
ZHEJIANG UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Drugs currently on the market for preventing constipation are divided into two categories: western medicine and traditional Chinese medicine. series of side effects

Method used

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  • Application of yeast glucan composition in preventing constipation
  • Application of yeast glucan composition in preventing constipation
  • Application of yeast glucan composition in preventing constipation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0050] Step 1) Ball milling into powder: fully mix 10g of baker's yeast powder and grinding aid sodium hydroxide solid, the addition amount of grinding aid is 20% by mass fraction, place in a drum type ball mill, add 30 medium-sized ball milling beads, Carry out ball milling extraction with a ball mill, rotating speed 100rpm, mixing and grinding for 30min;

[0051] Step 2) Alkali extraction: take NaOH solution as the extraction solution, the mass fraction of NaOH solution is 20%, and its mass consumption is 30 times of the quality of baker's yeast powder, carry out secondary alkali extraction to yeast powder, extract at 40 DEG C for 40min, Obtain yeast glucan crude extract;

[0052] Step 3) Purification Adding an appropriate amount of papain to the crude yeast glucan extract, performing enzymatic hydrolysis and purification, and using 1mol / L NaOH solution to maintain a constant pH to obtain an enzymatic hydrolysis solution;

[0053] Step 4) Drying: Put the enzymolysis solutio...

Embodiment 2

[0055] Step 1) Ball milling into powder: fully mix 10g of baker's yeast powder and grinding aid sodium hydroxide solid, the addition amount of grinding aid is 40% by mass fraction, place in a drum type ball mill, add 30 medium-sized ball milling beads, Carry out ball milling extraction with a ball mill, rotating speed 100rpm, mixing and grinding for 30min;

[0056] Step 2) alkaline extraction: take NaOH solution as the extraction solvent, the mass fraction is 30%, and its mass dosage is 30 times the quality of baker's yeast powder; the yeast powder is subjected to secondary microwave alkaline extraction, and extracted at 40°C for 40min to obtain Yeast glucan crude extract;

[0057] Step 3) Purification Adding an appropriate amount of papain to the crude yeast glucan extract, performing enzymatic hydrolysis and purification, and using 1mol / L NaOH solution to maintain a constant pH to obtain an enzymatic hydrolysis solution;

[0058] Step 4) Drying: Put the enzymolysis solution...

Embodiment 3

[0060] Step 1) ball milling into powder: fully mix 10g of baker's yeast powder and grinding aid sodium chloride solid, the addition amount of grinding aid is 80% by mass fraction, place in a drum type ball mill, add 30 medium-sized ball milling beads, Carry out ball milling extraction with a ball mill, rotating speed 100rpm, mixing and grinding for 30min;

[0061] Step 2) Alkaline extraction: NaOH solution is used as the extraction solvent, the mass fraction is 40%, and its mass dosage is 40 times of the mass of baker's yeast powder. The yeast powder was subjected to microwave alkaline extraction twice, and extracted at 40°C for 40 minutes to obtain the crude yeast glucan extract;

[0062] Step 3) Purification Adding an appropriate amount of cellulase to the crude yeast glucan extract, performing enzymatic hydrolysis and purification, and using 1 mol / L NaOH solution to maintain a constant pH to obtain an enzymatic hydrolysis solution;

[0063] Step 4) Drying: Put the enzymoly...

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Abstract

The present invention relates to an application of a yeast glucan composition for preparation of a medicine, food and a health care product for preventing constipation. The composition comprises yeastglucan and a probiotic, and the weight ratio of the yeast glucan to the probiotic is 1:1 to 10, The yeast glucan is prepared by the following steps: step 1) ball milling into powder: mixing baker's yeast and a grinding aid, and then performing ball milling on a mixture to obtain baker's yeast powder; step 2) alkaline extraction: extracting the baker's yeast powder with an extraction aid to obtaina crude yeast glucan extract; step 3) purification: taking the crude yeast glucan extract obtained in the step 2) and adding protease for enzymatic hydrolysis, wherein the pH is stabilized by supplemental addition of the extraction aid; and step 4) drying: heating for enzyme deactivation to obtain an enzymatic hydrolysate, separating the enzymatic hydrolysate to obtain a supernatant, and drying the supernatant to obtain yeast glucan.

Description

technical field [0001] The invention relates to the application of a yeast glucan composition in the preparation of medicines, food and health care products for preventing constipation Background technique [0002] Slow transit constipation (STC) is a complex clinical symptom caused by different pathological processes, which mainly refers to decreased defecation frequency, dry feces, and strenuous defecation, which seriously affect the quality of life of patients; intestinal water metabolism disorder is The main pathogenesis of constipation, especially the abnormal water transport in the colon, is directly related to it. Its main features are slow colonic transit, prolonged stool transit time, accompanied by abdominal distension, and dry stools. With the accelerated pace of life of modern people, the improvement of living standards, the change of diet structure and the aging of the social population, the prevalence of STC is gradually increasing, and it increases with age. ...

Claims

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Application Information

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IPC IPC(8): A61K35/747A61K35/745A61K35/741A61K31/716A61P1/10A23L33/21A23L33/135
CPCA61K31/716A61K35/747A61K35/745A61K35/741A61P1/10A23L33/21A23L33/135A61K2236/19A61K2236/331A23V2002/00A23V2400/11A23V2400/31A23V2400/125A23V2400/175A23V2400/113A23V2400/513A23V2400/515A23V2400/519A23V2400/51A23V2400/533A61K2300/00A23V2200/3202A23V2200/3204A23V2250/5042
Inventor 王平陈卓逸
Owner ZHEJIANG UNIV OF TECH
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