A polyhydroxyl natural product-mediated method for synthesizing dendritic gold nanoparticles for drug loading
A technology of nano-gold particles and natural products, which can be used in drug combination, nanotechnology, and pharmaceutical formulations. It can solve the problems of large nano-particle size, long reaction time, and high equipment requirements, and achieves mild and controllable reaction conditions and simple preparation process. , the effect of less energy consumption
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Embodiment 1
[0039] A method for polyhydroxy natural product-mediated synthesis of drug-loaded dendritic gold nanoparticles, comprising the steps of:
[0040] (1) Add 10 mL of water into a three-necked flask, then add 25 μL of 100 mmol / L aqueous auric acid chloride solution, stir magnetically and heat to boiling at 100° C. After boiling, add 300 μL of trisodium citrate aqueous solution with a concentration of 0.01g / mL to the solution, continue to stir, heat and boil at 100°C, the solution gradually turns pink until it turns wine red and does not change anymore, stop heating and cool To room temperature, that is, the gold seed solution.
[0041](2) At room temperature, add 10 mL of water into a small beaker, then add 15 μL of 100 mmol / L aqueous auric acid chloride solution, and stir evenly with magnetic force. Under magnetic stirring, add 60 μL of the gold seed solution in step (1); and under magnetic stirring, immediately add 60 μL of delphinidin aqueous solution with a concentration of 1...
Embodiment 2
[0047] A method for polyhydroxy natural product-mediated synthesis of drug-loaded dendritic gold nanoparticles, comprising the steps of:
[0048] (1) Add 10 mL of water into a three-necked flask, then add 25 μL of 100 mmol / L aqueous auric acid chloride solution, stir magnetically and heat to boiling at 100° C. After boiling, add 300 μL of trisodium citrate aqueous solution with a concentration of 0.01g / mL to the solution, continue to stir, heat and boil at 100°C, the solution gradually turns pink until it turns wine red and does not change anymore, stop heating and cool To room temperature, that is, the gold seed solution.
[0049] (2) At room temperature, add 10 mL of water into a small beaker, then add 15 μL of 100 mmol / L aqueous auric acid chloride solution, and stir evenly with magnetic force. Under magnetic stirring, add 30 μ L of the gold seed solution in step (1); and under magnetic stirring, immediately add 50 μ L of resveratrol dimethyl sulfoxide solution with a conc...
Embodiment 3
[0053] A method for polyhydroxy natural product-mediated synthesis of drug-loaded dendritic gold nanoparticles, comprising the steps of:
[0054] (1) Add 10 mL of water into a three-necked flask, then add 25 μL of 100 mmol / L aqueous auric acid chloride solution, stir magnetically and heat to boiling at 100° C. After boiling, add 300 μL of trisodium citrate aqueous solution with a concentration of 0.01g / mL to the solution, continue to stir, heat and boil at 100°C, the solution gradually turns pink until it turns wine red and does not change anymore, stop heating and cool To room temperature, that is, the gold seed solution.
[0055] (2) At room temperature, add 10 mL of water into a small beaker, then add 15 μL of 100 mmol / L aqueous auric acid chloride solution, and stir evenly with magnetic force. Under magnetic stirring, add 30 μ L of the gold seed solution in step (1); and under magnetic stirring, immediately add 30 μ L of a chlorogenic acid aqueous solution with a concentr...
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