Method for processing poecilobdella manillensis lesson

A leech, stage technology is applied in the field of processing of leech, can solve the problems affecting the curative effect of leech, the reduction of the active ingredient hirudin, the reduction of antithrombin activity, and the like, and is suitable for large-scale production and promotion. Avoid the effect of reduced antithrombin activity and stable product quality

Pending Publication Date: 2019-08-02
云南晟招制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

If the living body of Hirudo phenanthae is directly scalded to death, the antithrombin activity in the body will be reduced due to high temperature; if the blood stored in the body of Hirudo phenanthae after death is not drained, the activity of antithrombin will also be reduced; If it is dried at low temperature and powdered at room temperature, the antithromb

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0030] Example 1

[0031] Wash the philippines leeches with flowing purified water by spraying, wash and dry, then add 2% water of the philippines leeches by weight, and then freeze them at a temperature of -20°C for 3h until freezing to obtain material a; use material a The beating machine is homogenized to form a slurry to obtain material b; the material b is placed in a freeze-drying tray, and the temperature is -50℃~45℃ for gradient freeze-drying, after condensation and dehydration, Philippine leeches freeze-dried powder c is obtained; The dry powder c was pulverized at 10° C. at low temperature and passed through a 50-mesh sieve to obtain the target processed Philippine bull leech. The gradient temperature stage of gradient freeze-drying consists of 12 temperature stages, specifically -50℃~-40℃ temperature stage 5h, -40℃~-35℃ temperature stage 3h, -35℃~-20℃ temperature stage 6h, -20 ℃~-15℃ temperature stage 3h, -15℃~-5℃ temperature stage 3h, -5℃~0℃ temperature stage 3h, 0℃~...

Example Embodiment

[0032] Example 2

[0033] Wash the philippines leeches with flowing purified water by spraying, wash and dry, then add 5% water of the philippines leeches by weight, and then freeze at -20°C for 5h until freezing to obtain material a; use material a The beating machine is homogenized to form a slurry to obtain material b; the material b is placed in a freeze-drying tray, and the temperature is -50℃~45℃ for gradient freeze-drying, after condensation and dehydration, Philippine leeches freeze-dried powder c is obtained; The dry powder c was pulverized at a low temperature at 2°C and passed through a 50-mesh sieve to obtain the target processed philippines. The gradient temperature stage of gradient freeze-drying is 12 temperature stages, specifically -50℃~-40℃ temperature stage 10h, -40℃~-35℃ temperature stage 3h, -35℃~-20℃ temperature stage 3h, -20 ℃~-15℃ temperature stage 6h, -15℃~-5℃ temperature stage 6h, -5℃~0℃ temperature stage 3h, 0℃~8℃ temperature stage 3h, 8℃~15℃ temperatu...

Example Embodiment

[0034] Example 3

[0035] The Philippine cow leeches were sprayed and washed with flowing purified water, washed and dried, and then added with 3% water by weight of the Philip cow leeches, and then frozen at a temperature of -20°C for 4 hours until freezing to obtain material a; The beating machine is homogenized to form a slurry to obtain material b; the material b is placed in a freeze-drying tray, and the temperature is -50℃~45℃ for gradient freeze-drying, after condensation and dehydration, Philippine leeches freeze-dried powder c is obtained; The dry powder c was pulverized at a low temperature at 5° C. and passed through a 50-mesh sieve to obtain the target processed philippines. The gradient temperature stage of gradient freeze-drying is 12 temperature stages, specifically -50℃~-40℃ temperature stage 8h, -40℃~-35℃ temperature stage 5h, -35℃~-20℃ temperature stage 5h, -20 ℃~-15℃ temperature stage 4h, -15℃~-5℃ temperature stage 5h, -5℃~0℃ temperature stage 5h, 0℃~8℃ temper...

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PUM

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Abstract

The invention discloses a method for processing a poecilobdella manillensis lesson, comprising the following specific steps: washing and drying the poecilobdella manillensis lesson, adding water in 2-5% of the poecilobdella manillensis lesson by weight, and freezing at a temperature of -20 DEG C for 3 h-5 h till the poecilobdella manillensis lesson is frozen to obtain a material a; using a beaterto evenly beat the material a into pulp to obtain a material b; placing the material b in a freeze-drying tray, freeze-drying at a gradient at a temperature of -50-45 DEG C for 40 h-60 h, and conducting condensation and dehydration to obtain a freeze-dried oecilobdella manillensis lesson powder c; and crushing the freeze-dried oecilobdella manillensis lesson powder c at a low temperature and sieving to obtain the oecilobdella manillensis lesson processed from the target. The invention solves the problem of antithrombin activity reduction at a high temperature, while the blood is retained in the body of the oecilobdella manillensis lesson, so as to avoid the problem of antithrombin activity reduction due to drainage of the blood in the body of oecilobdella manillensis lesson, which may retain the active ingredients in the oecilobdella manillensis lesson to the utmost extent. The processing is simple and convenient, the production conditions is easy to control, the product quality is well controllable, and the processing is suitable for large-scale production and promotion.

Description

technical field [0001] The invention belongs to the technical field of medicinal material processing, and in particular relates to a processing method of Hirudo phenantha. Background technique [0002] Poecilobdella manillensis (Poecilobdella manillensis) is a blood-sucking leech, commonly known as Phnom Penh leech. It is the dried whole body of Poecilobdella manillensis, a species of Hirudidae. . There are records in "Famous Doctors", "Shen Nong's Materia Medica Collection", "Materia Medica", "Tang Materia Medica", "Compendium of Materia Medica" and other herbal medicines. "Tang Materia Medica" states, "There are leeches and grass leeches. The big ones are about a foot long, and those with blood in the abdomen are better to dry." [0003] Hirudo phenaridis is mainly distributed in Guangxi, Guangdong, Hainan, Fujian and other provinces, and lives by sucking the blood of vertebrates such as humans, livestock, and frogs in the natural environment. Hirudo phenanthrene has si...

Claims

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Application Information

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IPC IPC(8): A61K35/62F26B5/06
CPCA61K35/62F26B5/06
Inventor 马超王贵云
Owner 云南晟招制药有限公司
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