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Antibiotic-safety rumen preparation and preparation method thereof

A technology of antibiotics and rumen passage, which is applied in the direction of pharmaceutical formulations, antibacterial drugs, block delivery, etc. It can solve the problems of unfavorable absorption and utilization of nutrients, achieve high drug loading rate, realize large-scale production, and achieve the effect of reasonable structure

Inactive Publication Date: 2019-08-16
河南大华生物技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is currently a lack of a rumen-passing method for antibiotics
Unlike nutrients such as amino acids or choline, the leakage of antibiotics in the rumen will have a negative impact on the rumen microbial ecology of ruminants, which is not conducive to the absorption and utilization of nutrients

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] A kind of preparation that can make antibiotics safely pass through the rumen is prepared by the method comprising the following steps:

[0030] SS01. Add 5Kg of the antibiotic enrofloxacin into the nano ball mill to refine the antibiotic. The ball-to-material ratio during grinding is 15:1, the speed of the ball mill is 1500rpm, the grinding time is 12 hours, and the particle size of the antibiotic after ball milling is 50nm , dissolving enrofloxacin after ball milling in 20Kg methanol at normal temperature to obtain mixture A for subsequent use;

[0031] SS02, control the temperature to 65°C, heat and melt the granulation auxiliary materials and mix them evenly. The granulation auxiliary materials are 20Kg of stearic acid, 10Kg of lecithin, 25Kg of hydrogenated soybean oil, and 40Kg of hydrogenated palm oil;

[0032] SS03. Shear the melted granulation auxiliary material in a homogeneous tank under 0.2 atmospheric pressure, add mixture A while shearing, set the rotation...

Embodiment 2

[0035] A kind of preparation that can make antibiotics safely pass through the rumen is prepared by the method comprising the following steps:

[0036] SS01. Add 5Kg of the antibiotic aureomycin hydrochloride into the nano ball mill to refine the antibiotic nanometer. The ball-to-material ratio during grinding is 20:1, the speed of the ball mill is 1200rpm, the grinding time is 18 hours, and the particle size of the antibiotic after ball milling is 50nm ;

[0037] SS02, control the temperature at 80°C, heat and melt the granulation auxiliary materials and mix them evenly. The granulation auxiliary materials are 2Kg of cellulose acetate, 3Kg of hydroxypropyl methylcellulose, 10Kg of calcium stearate, 5Kg of refined palm oil, hydrogenated 25Kg peanut oil, 45Kg palmitic acid;

[0038] SS03. Shear the melted granulation auxiliary material in a homogeneous tank under 0.2 atmospheric pressure, add the antibiotic after ball milling while shearing, set the speed at 14000rpm, and shea...

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Abstract

The invention relates to an antibiotic-safety rumen preparation and a preparation method thereof. The preparation comprises the following active substances and granulation auxiliary in parts by weight: 1 to 200 parts of antibiotic; 30 to 300 parts of a solvent and a dispersant; and 500 to 1000 parts of a granulation auxiliary. The method firstly disperses the antibiotics, increases the surface area thereof as much as possible, improves the bioavailability, and evenly distributes the antibiotic in the rumen preparation, and can better pass the rumen preparation through the rumen. Moreover, theparticle size of the ball-milled nanoparticles is uniform, the ball-milled nanoparticles contain sufficient crystal defects, which can effectively inhibit the re-polymerization into micro-particles, greatly improves the surface area of the antibiotic, and reduces the particle size of the drug, so that the uniformity and encapsulation efficiency of antibiotics in the rumen preparation are greatly increased, and the nano-medicine promotes the absorption of the drug.

Description

technical field [0001] The invention relates to the technical field of veterinary drug preparations, in particular to a preparation capable of allowing antibiotics to safely pass through the rumen and a preparation method thereof. Background technique [0002] Ruminants refer to animals that return half-digested food in the stomach to their mouths for chewing again after eating for a period of time, usually some herbivores. The most significant difference between ruminants and monogastric animals is that they have four stomach chambers Among them, the rumen is inhabited by complex, diverse, and non-pathogenic microorganisms, including rumen bacteria, anaerobic fungi, and rumen protozoa, as well as a small number of bacteriophages. Plant matter plays a decisive role, providing an important source of nutrition for the host. [0003] In view of the important role of rumen microorganisms in host nutrition, any disturbance to the original ecology of rumen microorganisms may have...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/16A61K9/00A61P31/04
CPCA61K9/0068A61K9/1623A61P31/04
Inventor 徐天天徐其常
Owner 河南大华生物技术有限公司
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