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New application of dihydrochalcone compound renifolin F

A technology of dihydrochalcones and compounds, applied in the field of medical technology and health care products, to achieve the effect of inhibiting the production of inflammatory factors and improving pathological changes

Active Publication Date: 2022-04-01
YUNNAN UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] At present, there are no reports on the efficacy of Renifolin F in preventing asthma in domestic and foreign literature

Method used

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  • New application of dihydrochalcone compound renifolin F
  • New application of dihydrochalcone compound renifolin F
  • New application of dihydrochalcone compound renifolin F

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0054] Embodiment 1: the preparation of Renifolin F

[0055] Dried copper money ephedra root (5 kg), crushed and extracted with 10L of 70% ethanol under reflux for 3 times, each time for 2 hours, the extract was concentrated under reduced pressure until it had no alcohol smell, and ethanol extract (1.8 kg) was obtained. After dispersing the extract with 1L of water, extract and degrease once with 1L of petroleum ether, then extract with ethyl acetate three times, 2L each time, combine the ethyl acetate extracts, recover under reduced pressure to obtain ethyl acetate extract (0.9 kg) .

[0056] Ethyl acetate extract was eluted by silica gel column chromatography (chloroform-methanol system) gradient (100:5-100:100), the obtained fractions were detected by thin-layer chromatography, and the fractions containing Renifolin F were combined (20 g) , after MCI column chromatography, methanol-water (0:100-100:0) gradient elution, each fraction was identified by thin-layer chromatogra...

Embodiment 2

[0060] Embodiment 2: The therapeutic effect of Renifolin F on mouse asthma

[0061] 1. Reagents: OVA (batch number: 9006-59-1) and dexamethasone (batch number: BCBV3214) were purchased from Sigma Company; Eotaxin ELISA detection kit (batch number: 2130802231), IL-4 ELISA detection kit (batch number: A20480141 ), IL-5 ELISA kit (lot number: A20580821), IL-13 ELISA kit (lot number: A21381132), IL-25 ELISA kit (lot number: M181225-007a), IL-33 ELISA kit (Lot No.: A23380314), INF-γ ELISA Kit (Lot No.: A201B81053), MUC5AC ELISA Kit (Lot No.: ZKVBMELGV3), TSLP ELISA Kit (Lot No.: A26580933), IL-2 ELISA Kit (Lot No. : A20280153), IL-6 ELISA kit (lot number: A20681154), IL-7 ELISA kit (lot number: A20781123), IL-9 ELISA kit (lot number: A20980513), IL-10 ELISA kit (Lot No.: A21090121), IL-17A ELISA Detection Kit (Lot No.: A21780741), MCP-1 ELISA Detection Kit (Lot No.: A28780431), Total IgE ELISA Detection Kit (Lot No.: A27581115) were purchased from Hangzhou Lianke Biotechnology Co...

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PUM

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Abstract

The invention discloses the application of dihydrochalcone compound Renifolin F in the preparation of drugs for preventing or treating bronchial asthma. Pharmacological experiments have shown that Renifolin F can significantly improve the pathological changes in the lung tissue of ovalbumin-sensitized mice, and inhibit the production of various inflammatory factors in serum and alveolar lavage fluid. It shows that Renifolin F can effectively antagonize asthma, is suitable for preparing new drugs for preventing and treating bronchial asthma, and has broad application prospects and great potential value.

Description

technical field [0001] The invention belongs to the field of medical technology and health products, and in particular relates to the application of flavonoid compound Renifolin F in preventing and treating bronchial asthma. Background technique [0002] Bronchial asthma (asthma for short, Asthma) is a heterogeneous disease characterized by chronic airway inflammation, airway hyperresponsiveness, and airway mucus hypersecretion. The main clinical symptoms are recurrent wheezing, shortness of breath, chest tightness, coughing, etc. , multiple at night and early morning. The disease is caused by the combination of genetic factors and environmental factors. It is a common and frequently-occurring disease worldwide, and can be affected by all age groups. According to statistics, there are currently at least 300 million patients in the world, about 30 million in China, and the number of patients in Western Europe has doubled in the past 10 years. With economic development and ch...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/12A61P11/06A61K36/48
CPCA61K31/12A61P11/06A61K36/48
Inventor 杨竹雅黄丰刘录马晓霞谭文红
Owner YUNNAN UNIV OF TRADITIONAL CHINESE MEDICINE