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Bone cement based on bio-based polyurethane composite degradable material and preparation method thereof

A technology for degrading materials and bone cement, which is used in tissue regeneration, medical science, prosthesis, etc. It can solve the problems of insufficient degradation rate capability, insufficient mechanical strength of bone cement, and inability to achieve autologous bone in situ regeneration, and achieve good biodegradation. The effect of good biocompatibility

Active Publication Date: 2019-08-16
BEIJING BEST LIFE REGENERATIVE MEDICINE TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] In order to overcome the lack of mechanical strength of the existing bone cement, after injection into the human bone defect, due to the rapid degradation rate and insufficient ability to induce bone formation, the bone defect often collapses to varying degrees, and there is a risk of complications such as nerve damage, so it cannot be realized. In situ regeneration of autologous bone

Method used

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  • Bone cement based on bio-based polyurethane composite degradable material and preparation method thereof
  • Bone cement based on bio-based polyurethane composite degradable material and preparation method thereof
  • Bone cement based on bio-based polyurethane composite degradable material and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0065] Prepare solid phase powder materials, bio-based polyurethane prepolymers, accelerators, initiators, polymerization inhibitors and other raw materials.

[0066] (1) The solid phase powder material accounts for 50% of the bone cement raw material mass sum, and the solid phase powder material of this embodiment is only the Regesi regenerated silicon material (that is, the Regesi regenerated silicon material accounts for 100% of the solid phase powder material gross weight ), in an environment of 25°C, the Regesi regenerated silicon powder material is screened for particle size, and the Regesi regenerated silicon powder body with a particle size of 10 μm-60 μm is used for subsequent use, and then the coupling agent KH570 (the molecular formula of KH570 is: CH 2 =C(CH 3 )COOC 3 h 6 Si(OCH 3 ) 3 ) Surface modification of the screened solid phase powder material, the specific modification method is as follows:

[0067] After ultrasonically mixing the solid phase powder, a...

Embodiment 2

[0086] Prepare solid phase powder materials, bio-based polyurethane prepolymers, accelerators, initiators, polymerization inhibitors and other raw materials.

[0087] (1) Solid-phase powder materials account for 50% of the total mass of bone cement raw materials. Weigh various powder materials according to the formula of solid-phase powder materials below, and measure the particle size of various powder materials in an environment of 25°C. Screening, select powder materials with a particle size of 10 μm-60 μm for use, and then use a coupling agent to carry out surface modification treatment on the screened solid phase powder materials. The specific modification method is as follows: modify the solid phase powder materials separately and then mix them, and use the same method as in Example 1 for modification.

[0088] According to mass percentage, the ingredients of solid phase powder materials are as follows:

[0089]

[0090](2) The initiator benzoyl peroxide and accelera...

Embodiment 3

[0096] Prepare solid phase powder materials, bio-based polyurethane prepolymers, accelerators, initiators, polymerization inhibitors and other raw materials.

[0097] (1) The solid phase powder accounts for 50% of the total mass of the bone cement. According to the mass proportion of each powder in the solid phase, the particle size of the powder material is screened in an environment of 25°C, and the particle size of the solid powder is optimized. : 10μm-60μm, use the coupling agent to modify the surface of the screened solid phase powder. The specific modification method is as follows: modify the solid phase powder materials separately and then mix them, and use the same method as in Example 1 for modification.

[0098] According to mass percentage, the ingredients of solid phase powder materials are as follows:

[0099] 45S5 bioactive glass powder 74%

[0100] Bioactive Glass 58S Reinforcing Fiber 5%

[0101] Hydroxyapatite 21%

[0102] (2) The initiator benzoyl peroxid...

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Abstract

The invention discloses a bone cement of a bio-based polyurethane composite degradable material, which is composed of a solid phase powder material and a liquid phase composite, wherein the solid phase powder mainly comprises inorganic powder and / or a prepolymerized organic filler insoluble in a polyurethane monomer, doped reinforcing fibers and other functional powders. The liquid phase compositemainly comprises a bio-based polyurethane prepolymer and a liquid phase monomer diluent. The liquid phase composite is slowly added to the solid phase powder material, and the materials are sufficiently mixed and solidified to form the bone cement. The bone cement can completely replace the bone cement such as PMMA, calcium phosphate and calcium sulfate on the market, and has excellent biologicalactivity and the ability to promote new bone formation. After injecting into the human bone defect site, the mechanical properties are excellent, the polymerization reaction produces less heat, and the bone cement degradation rate is matched with the new bone formation inducing speed, and the autologous bone in-situ regeneration is achieved to ensure stable and controllable bone increment.

Description

technical field [0001] The invention belongs to the technical field of bone cement for orthopedic repair, and relates to a bone cement based on a bio-based polyurethane composite degradable material and a preparation method thereof. Background technique [0002] Bone defects are often caused by trauma, infection, osteoporosis, tumors, or congenital deformities. Among them, osteoporosis causes about 8.9 million fractures in patients worldwide every year, with an average of one case every 3 seconds, about three times. One in every woman and one in five men over the age of 50 will experience an osteoporotic fracture in their lifetime. Osteoporotic vertebral compression fracture (Osteoporotic Vertebral Compression Fracture, OVCF) is the most common osteoporotic fracture, accounting for about 50%. common problems. [0003] At present, the traditional acrylic bone cement represented by polymethylmethacrylate bone cement (Polymethylmethacrylate cement, PMMA), calcium phosphate bo...

Claims

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Application Information

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IPC IPC(8): A61L27/44A61L27/58
CPCA61L27/44A61L27/58A61L2430/02C08L75/04
Inventor 王健胡方王菲仇越秀
Owner BEIJING BEST LIFE REGENERATIVE MEDICINE TECH CO LTD
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