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Nano-package leonurine lipidosome and preparing method and application thereof

A technology of motherwort and motherwort, which is applied in the field of nano-encapsulated motherwort liposome and its preparation, and achieves the effects of wide application prospect, water retention and long-term stability

Inactive Publication Date: 2019-08-23
广东萱嘉医品健康科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Therefore, it is expected to overcome the application limitations caused by the structure of leonurine itself if it is applied to cosmetics after encapsulating it with nanostructured liposomes. However, there are no relevant reports in the prior art.

Method used

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  • Nano-package leonurine lipidosome and preparing method and application thereof

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Embodiment 5

[0071] Embodiment 5 of the present invention is: a kind of preparation method of nano-encapsulated Leonurine liposome anti-inflammatory and acne-removing face cream, this face cream is made of the raw material of following quality components, nano-encapsulated Leonurine liposome (above embodiment 2 Prepared) 4.5wt%; Deionized water: 74.18wt%; Hyaluronic acid: 0.05wt%; Glycerin: 4wt%; Cyclodimethylsiloxane (DC345): 2.3wt%; Dimethicone ( DC200 / 100): 3.1wt%; Tocopherol: 2.6wt%; Squalane: 2.5wt%; GTCC: 2.1wt%; Shea Butter: 2.3wt%; : 0.09wt%.

[0072] Including the following steps:

[0073] (1) Phase A preparation: Add deionized water, glycerin, and hyaluronic acid into the beaker at one time, stir at high speed until evenly dispersed, and the stirring speed is 700r / min;

[0074] (2) Warm up to 90°C under even stirring, keep stirring at a constant speed for 20 minutes to sterilize;

[0075] (3) Phase B preparation: take another beaker, add DC345, DC200 / 100, tocopherol, squalane,...

Embodiment 6

[0078] Embodiment 6 of the present invention is: a kind of preparation method of nano-encapsulated Leonurine liposome anti-inflammation and acne-removing face cream, the face cream is made of the raw materials of the following quality components, nano-encapsulated Leonurine liposome (above embodiment 3 Prepared) 5wt%; Deionized water: 73.77wt%; Hyaluronic acid: 0.03wt%; Glycerin: 4wt%; Cyclodimethylsiloxane (DC345): 2.5wt%; Dimethicone (DC200 / 100): 1.5wt%; Tocopherol: 2.9wt%; Squalane: 1.5wt%; GTCC: 3wt%; Shea butter: 2.3wt%; Emulsion thickener 305: 3wt%; %.

[0079] Including the following steps:

[0080] (1) Phase A preparation: Add deionized water, glycerin, and hyaluronic acid into the beaker at one time, stir at high speed until evenly dispersed, and the stirring speed is 800r / min;

[0081] (2) Warm up to 90°C under even stirring, keep stirring at a constant speed for 20 minutes to sterilize;

[0082] (3) Phase B preparation: take another beaker, add DC345, DC200 / 100,...

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Abstract

The invention discloses a nano-package leonurine lipidosome and a preparing method and application thereof. The nano-package leonurine lipidosome is prepared from, by weight, 0.1-5 parts of leonurine,1-4 parts of vitamin C, 5-40 parts of lecithin, 10-20 parts of cholesterol and 1-100 parts of glycerinum. The preparing method comprises the following steps of S1, mixing the lecithin, the cholesterol and the glycerinum, then heating the mixture until the mixture is completely dissolved, conducting sterilization treatment, and adding ethyl alcohol in a sterilized solution to obtain a mixed solution; S2, injecting the leonurine and the vitamin C, and conducting heat-preservation stirring; S3, treating a product under the condition of high pressure homogenization, and obtaining the nano-packageleonurine lipidosome after drying. The nano-package leonurine lipidosome has a slow-release effect, active substances can be slowly released for a long term on the focus, and a remarkable biologicaleffect is achieved; meanwhile, adverse skin reactions caused by high-concentration and large-dosage leonurine are avoided.

Description

technical field [0001] The invention relates to the technical field of cosmetics, in particular to a nano-encapsulated leonurine liposome and a preparation method and application thereof. Background technique [0002] Leonurine is an alkaloid extracted and isolated from the traditional Chinese medicine Motherwort. At present, there are many clinical preparations of Motherwort, such as capsules, tablets, ointments, granules and injections. In recent years, relevant studies have found that motherwortine also has properties such as anti-oxidation, anti-apoptosis, antibacterial, and anti-acne. Therefore, there are more and more studies on the use of motherurine in cosmetics. However, due to the high polarity of the phenolic hydroxyl group and the guanidine group contained in the structure of leonurine, the poor fat solubility, weak transmembrane ability and low bioavailability of leonurine are caused. Moreover, motherwortine is highly toxic, and directly acting on the skin will...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/92A61K8/14A61K8/34A61K8/41A61K8/67A61K9/127A61K31/216A61K47/28A61P17/10A61P29/00A61Q19/00
CPCA61K8/14A61K8/345A61K8/41A61K8/676A61K8/922A61K9/127A61K31/216A61K47/28A61K2800/56A61Q19/00A61P17/10A61P29/00
Inventor 张嘉恒袁菊懋张晃淳苏晶梁一红詹憬博
Owner 广东萱嘉医品健康科技有限公司
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