Nano-package leonurine lipidosome and preparing method and application thereof
What is Al technical title?
Al technical title is built by PatSnap Al team. It summarizes the technical point description of the patent document.
A technology of motherwort and motherwort, which is applied in the field of nano-encapsulated motherwort liposome and its preparation, and achieves the effects of wide application prospect, water retention and long-term stability
Inactive Publication Date: 2019-08-23
广东萱嘉医品健康科技有限公司
View PDF3 Cites 4 Cited by
Summary
Abstract
Description
Claims
Application Information
AI Technical Summary
This helps you quickly interpret patents by identifying the three key elements:
Problems solved by technology
Method used
Benefits of technology
Problems solved by technology
[0004] Therefore, it is expected to overcome the application limitations caused by the structure of leonurine itself if it is applied to cosmetics after encapsulating it with nanostructured liposomes. However, there are no relevant reports in the prior art.
Method used
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more
Image
Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
Click on the blue label to locate the original text in one second.
Reading with bidirectional positioning of images and text.
Smart Image
Examples
Experimental program
Comparison scheme
Effect test
Embodiment 5
[0071] Embodiment 5 of the present invention is: a kind of preparation method of nano-encapsulated Leonurine liposome anti-inflammatory and acne-removing face cream, this face cream is made of the raw material of following quality components, nano-encapsulated Leonurine liposome (above embodiment 2 Prepared) 4.5wt%; Deionized water: 74.18wt%; Hyaluronic acid: 0.05wt%; Glycerin: 4wt%; Cyclodimethylsiloxane (DC345): 2.3wt%; Dimethicone ( DC200 / 100): 3.1wt%; Tocopherol: 2.6wt%; Squalane: 2.5wt%; GTCC: 2.1wt%; Shea Butter: 2.3wt%; : 0.09wt%.
[0072] Including the following steps:
[0073] (1) Phase A preparation: Add deionized water, glycerin, and hyaluronic acid into the beaker at one time, stir at high speed until evenly dispersed, and the stirring speed is 700r / min;
[0074] (2) Warm up to 90°C under even stirring, keep stirring at a constant speed for 20 minutes to sterilize;
[0075] (3) Phase B preparation: take another beaker, add DC345, DC200 / 100, tocopherol, squalane,...
Embodiment 6
[0078] Embodiment 6 of the present invention is: a kind of preparation method of nano-encapsulated Leonurine liposome anti-inflammation and acne-removing face cream, the face cream is made of the raw materials of the following quality components, nano-encapsulated Leonurine liposome (above embodiment 3 Prepared) 5wt%; Deionized water: 73.77wt%; Hyaluronic acid: 0.03wt%; Glycerin: 4wt%; Cyclodimethylsiloxane (DC345): 2.5wt%; Dimethicone (DC200 / 100): 1.5wt%; Tocopherol: 2.9wt%; Squalane: 1.5wt%; GTCC: 3wt%; Shea butter: 2.3wt%; Emulsion thickener 305: 3wt%; %.
[0079] Including the following steps:
[0080] (1) Phase A preparation: Add deionized water, glycerin, and hyaluronic acid into the beaker at one time, stir at high speed until evenly dispersed, and the stirring speed is 800r / min;
[0081] (2) Warm up to 90°C under even stirring, keep stirring at a constant speed for 20 minutes to sterilize;
[0082] (3) Phase B preparation: take another beaker, add DC345, DC200 / 100,...
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more
PUM
Property
Measurement
Unit
particle diameter
aaaaa
aaaaa
Login to view more
Abstract
The invention discloses a nano-package leonurine lipidosome and a preparing method and application thereof. The nano-package leonurine lipidosome is prepared from, by weight, 0.1-5 parts of leonurine,1-4 parts of vitamin C, 5-40 parts of lecithin, 10-20 parts of cholesterol and 1-100 parts of glycerinum. The preparing method comprises the following steps of S1, mixing the lecithin, the cholesterol and the glycerinum, then heating the mixture until the mixture is completely dissolved, conducting sterilization treatment, and adding ethyl alcohol in a sterilized solution to obtain a mixed solution; S2, injecting the leonurine and the vitamin C, and conducting heat-preservation stirring; S3, treating a product under the condition of high pressure homogenization, and obtaining the nano-packageleonurine lipidosome after drying. The nano-package leonurine lipidosome has a slow-release effect, active substances can be slowly released for a long term on the focus, and a remarkable biologicaleffect is achieved; meanwhile, adverse skin reactions caused by high-concentration and large-dosage leonurine are avoided.
Description
technical field [0001] The invention relates to the technical field of cosmetics, in particular to a nano-encapsulated leonurine liposome and a preparation method and application thereof. Background technique [0002] Leonurine is an alkaloid extracted and isolated from the traditional Chinese medicine Motherwort. At present, there are many clinical preparations of Motherwort, such as capsules, tablets, ointments, granules and injections. In recent years, relevant studies have found that motherwortine also has properties such as anti-oxidation, anti-apoptosis, antibacterial, and anti-acne. Therefore, there are more and more studies on the use of motherurine in cosmetics. However, due to the high polarity of the phenolic hydroxyl group and the guanidine group contained in the structure of leonurine, the poor fat solubility, weak transmembrane ability and low bioavailability of leonurine are caused. Moreover, motherwortine is highly toxic, and directly acting on the skin will...
Claims
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more
Application Information
Patent Timeline
Application Date:The date an application was filed.
Publication Date:The date a patent or application was officially published.
First Publication Date:The earliest publication date of a patent with the same application number.
Issue Date:Publication date of the patent grant document.
PCT Entry Date:The Entry date of PCT National Phase.
Estimated Expiry Date:The statutory expiry date of a patent right according to the Patent Law, and it is the longest term of protection that the patent right can achieve without the termination of the patent right due to other reasons(Term extension factor has been taken into account ).
Invalid Date:Actual expiry date is based on effective date or publication date of legal transaction data of invalid patent.
Login to view more