Biodegradable oil-in-water-in-oil emulsion and preparation method thereof
A water-in-oil emulsion and oil-in-water technology, which can be used in emulsion delivery, drug combination, pharmaceutical formulation, etc., can solve problems such as serious compatibility and excessive dependence, and achieve the effect of less side effects and increased strength
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Method used
Image
Examples
preparation example Construction
[0056] The preparation method of the biodegradable water-in-oil-in-water emulsion of the present invention comprises the following steps:
[0057] (1) uniformly mix medicinal mineral oil or vegetable oil, lipophilic emulsifier and fatty acid, add the second type of solid particles, and ultrasonically disperse to obtain the internal oil phase;
[0058] (2) adding an internal water phase to the internal oil phase, shearing and dispersing evenly to obtain a water-in-oil emulsion;
[0059] (3) ultrasonically mix the water phase with the first type of solid particles, or dissolve the hydrophilic emulsifier in the water phase and then ultrasonically mix with the first type of solid particles to obtain the external water phase;
[0060] (4) Dropping the water-in-oil emulsion into the external water phase, shearing and uniformly dispersing to obtain the water-in-oil-in-water emulsion.
[0061] Wherein, in step (1), the percentage by weight of mineral oil or vegetable oil, lipophilic ...
Embodiment 1
[0071] This embodiment provides a kind of poly (D, L-lactic acid-glycolic acid) copolymer (PLGA) and nano-calcium carbonate to prepare water-in-oil-in-water emulsion, see figure 1 , is shown as the schematic diagram of the structure of the water-in-oil-in-water Pickering emulsion of the present invention, and the preparation process comprises the following steps:
[0072] 1. Preparation of PLGA nanoparticles:
[0073] Accurately take 0.8g PLGA dissolved in 35mL acetone, use a syringe pump to drop it into 0.25% PVA aqueous solution, and leave it open overnight to stir and volatilize. The solution in which the PLGA nanoparticles were dispersed was frozen at -22° C., and then freeze-dried at 0.12 kPa to obtain PLGA nanoparticles. As determined by dynamic light scattering (DLS), the obtained particles had an average particle diameter of 168 nm and a zeta potential of -3.09 mV.
[0074] 2. Nano calcium carbonate hydrophobic modification:
[0075] Accurately take 0.1g of stearic ...
Embodiment 2
[0081] This embodiment provides a kind of adopting PLGA and nano-hydroxyapatite to prepare water-in-oil-in-water emulsion, comprising the following steps:
[0082] 1. Preparation of PLGA nanoparticles:
[0083] Accurately take 0.8g PLGA dissolved in 35mL acetone, use a syringe pump to drop it into 0.25% PVA aqueous solution, and leave it open overnight to stir and volatilize. The solution in which the PLGA nanoparticles were dispersed was frozen at -22° C., and then freeze-dried at 0.12 kPa to obtain PLGA nanoparticles. As determined by DLS, the obtained particles had an average particle diameter of 168 nm and a zeta potential of -3.09 mV.
[0084] 2. Hydrophobic modification of nano-hydroxyapatite:
[0085] Accurately take 0.1g of stearic acid and dissolve it in 100mL of ethanol, add 1g of nano-hydroxyapatite to it and ultrasonically disperse, and react at 80°C for 4h. Centrifuge at 8000rpm for 15min with a centrifuge to collect the precipitate. After washing with ethanol...
PUM
| Property | Measurement | Unit |
|---|---|---|
| particle diameter | aaaaa | aaaaa |
| particle diameter | aaaaa | aaaaa |
| particle diameter | aaaaa | aaaaa |
Abstract
Description
Claims
Application Information
Login to View More