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Chitosan wrapped gamma-aminobutyric acid salicylic acid and preparation method and application thereof

A technology of GABA salicylic acid and GABA salicylic acid, which is applied in the chemical industry, can solve the problems of inability to directly contact with the skin, poor water solubility of salicylic acid, strong irritation of salicylic acid, etc., and achieve easy operation and good Oxidation resistance, the effect of simple synthesis steps

Active Publication Date: 2019-09-06
SHENZHEN SHINESKY BIOLOGICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, salicylic acid has poor water solubility, which limits its application effect, and salicylic acid is highly irritating and cannot be directly contacted with the skin.

Method used

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  • Chitosan wrapped gamma-aminobutyric acid salicylic acid and preparation method and application thereof
  • Chitosan wrapped gamma-aminobutyric acid salicylic acid and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] Embodiment 1 of the present invention is: a kind of preparation method of chitosan gamma-aminobutyric acid salicylic acid, comprises the following steps:

[0048] (1) Preparation of γ-aminobutyric acid salicylic acid ionic liquid: Weigh 1.03g of γ-aminobutyric acid (10mmol), add 20mL of deionized water, and inject N 2 (inert gas can also be used), so that the whole reaction is carried out under N 2 The reaction is carried out under atmosphere, the reaction vessel is placed in a normal temperature water bath, the reaction temperature is kept at 25° C., and the reaction vessel is shielded from light to ensure that the reaction is carried out under light-proof conditions. Weigh 1.38g of salicylic acid (10mmol), the molar ratio of γ-aminobutyric acid to salicylic acid is 1:1, a small amount of multiple rapid additions (usually 3 to 5 times within 2min is advisable, in this example , adding salicylic acid into the solution in 4 times) into the reaction vessel to ensure that...

Embodiment 2

[0051] Embodiment 2 of the present invention is: a kind of cosmetics containing chitosan-wrapped gamma-aminobutyric acid salicylic acid, its preparation raw material is made up of following components: deionized water: 76.25wt%; AVC: 0.13wt%; HA ( Medium molecule): 0.05wt%; PEG-26 glyceryl ether: 1.2wt%; glycerol: 2.3wt%; betaine: 3.2wt%; dipropylene glycol: 4.5wt%; WSK-1: 3.3wt%; γ-aminobutyric acid salicylic acid ionic liquid: 4wt%; Niacinamide: 0.78wt%; 1,2-hexanediol: 0.42wt%; A631: 0.24wt%; 261: 3.6wt%; RH-60: 0.03 wt%.

[0052] Concrete preparation process is as follows:

[0053] 1) Soak AVC and HA (medium molecular weight) in deionized water completely, and disperse them homogeneously in a homogenizer at a stirring speed of 3000r / min, then add PEG-26 glyceryl ether, glycerin, betaine, For dipropylene glycol, heat up to 85°C, homogenize at a medium speed for 3 minutes, stir at a homogeneous speed of 4000r / min and keep stirring for 30 minutes.

[0054] 2) Cool the prod...

Embodiment 3

[0056] Example 3 of the present invention is: a cosmetic containing chitosan-wrapped γ-aminobutyric acid salicylic acid, its preparation raw materials are composed of the following components: deionized water: 64.38wt%; AVC: 0.22wt%; Molecule: 0.14wt%; PEG-26 glyceryl ether: 2.1wt%; glycerol: 3.5wt%; betaine: 4.5wt%; dipropylene glycol: 8.2wt%; WSK-1: 4.7wt%; GABA salicylic acid ionic liquid: 6wt%; nicotinamide: 1.1wt%; 1,2-hexanediol: 0.54wt%; A631: 0.6wt%; 261: 4wt%; RH-60: 0.02wt%.

[0057] Concrete preparation process is as follows:

[0058] 1) Completely soak the molecules of AVC and HA in deionized water, and homogeneously disperse them completely in the homogenizer. , heat up to 85°C, homogenize at a medium speed for 3 minutes, stir at a homogenizing speed of 5000r / min and keep stirring for 30 minutes.

[0059] 2) Cool the product obtained in step 1 to 40°C, add WSK-1, chitosan-wrapped γ-aminobutyric acid salicylic acid ionic liquid, nicotinamide, 1,2-hexanediol, A631...

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Abstract

The invention discloses chitosan wrapped gamma-aminobutyric acid salicylic acid and a preparation method and application thereof. The preparation method includes following steps: S1, adding chitosan into a glacial acetic acid solution to obtain a chitosan water solution; S2, during stirring, dropwise adding gamma-aminobutyric acid salicylic acid ion liquid into the chitosan water solution, and standing at room temperature to obtain the chitosan wrapped gamma-aminobutyric acid salicylic acid. Compared with the prior art, the chitosan wrapped gamma-aminobutyric acid salicylic acid has the advantages that the acid prepared by the method has high solubility in oil-system or water-system solvents; through chitosan wrapping, irritation caused by salicylic acid can be lowered; slow-release effectcan be realized, so that efficacy is more lasting; the prepared acid has physiological effect of chitosan, salicylic acid and gamma-aminobutyric acid and has good application prospect in the field ofcosmetics and medicine.

Description

technical field [0001] The invention relates to the field of chemical industry, in particular to chitosan-wrapped gamma-aminobutyric acid salicylic acid and its preparation method and application. Background technique [0002] Chitosan is obtained from shrimp and crab shells through a series of treatments. It is non-toxic and tasteless. It has been widely used in food, medicine and other industries. Chitosan has immunoregulatory activity and can effectively promote wound healing. For example, adding an appropriate amount of chitosan to cream cosmetics can increase the body's immunity to infections caused by bacteria and fungi, hinder the growth of original bacteria, and not only prevent infection of damaged skin, but also promote its healing and eliminate facial diseases. At the same time, when chitosan is used for cosmetics, it is easy to form a protective film, and its moisture absorption and water retention effects can make the skin soft, moist and extensible. In additio...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/73A61K8/44A61K8/368A61Q19/00A61Q19/08
CPCA61K8/736A61K8/44A61K8/368A61Q19/00A61Q19/08A61K2800/56A61K2800/72
Inventor 张嘉恒袁菊懋余明远王岩廖雅张晃淳詹景博
Owner SHENZHEN SHINESKY BIOLOGICAL TECH CO LTD