A non-antibiotic colitis repair preparation

A technology for ulcerative colitis and preparations, which is applied in the field of non-antibiotic colitis repair preparations, can solve the problems such as less reports on non-antibiotic colitis repair methods, unsatisfactory results obtained, health damage, etc., and achieves good prevention and treatment effects, Good antibacterial effect and the effect of promoting weight gain

Active Publication Date: 2021-09-24
QINGDAO AGRI UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, Western medicine treatment is relatively limited, such as aminosalicylic acid, immunosuppressant, microbial preparations, etc., the effect is not ideal, and long-term drug treatment will cause residues that will cause certain health damage to the human body
At present, there are few reports on effective non-antibiotic colitis repair methods

Method used

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  • A non-antibiotic colitis repair preparation
  • A non-antibiotic colitis repair preparation
  • A non-antibiotic colitis repair preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Embodiment 1: Determination study of oregano oil and GDG synergistic antibacterial activity

[0016] Goose oil diglyceride was placed in a constant temperature water bath at 40°C to change from semi-solid to liquid, and the oregano oil was placed at room temperature for 10 minutes. The two are mixed in a constant temperature magnetic stirrer according to the relevant concentration ratio of the test requirements, the temperature is 30-50 °C, the time is 3-8 min, and the rotation speed is 300-800 rpm.

[0017] (1) Test scheme: The in vitro antibacterial activity of oregano oil and GDG synergistically against Escherichia coli was determined by plate punching method. Coliform bacteria were activated in Luria-Bertani (LB) broth for 24h at 36±1℃. On a clean bench, the suction concentration is 1×10 8 20ul of the suspension of Escherichia coli with CFU / mL was placed in a sterile plate, and poured into the LB nutrient agar that was about to solidify, so that it was quickly mix...

Embodiment 2

[0022] Example 2: Study on the curative effect of the mixture of oregano oil and GDG on ulcerative colitis model rats

[0023] (1) Experimental animals and groups

[0024] 84 7-week-old male SD rats with a body weight of about 200 g from Qingdao Institute for Drug Control were selected for this experiment, and were reared adaptively for 5 days. The animals were randomly divided into 6 groups of 14 animals each. Fourteen rats in each group were housed in two cages (seven per cage) and fed with standard chow purchased from China Nantong Feed Technology Company. The rats in each group were allowed to drink water and feed freely.

[0025] (2) Modeling and repair test plan

[0026] The experimental treatments are shown in Table 2, and the corresponding samples were administered by gavage according to body weight (BW). Group I was the healthy control group. The rats in groups Ⅱ, Ⅲ, Ⅳ, Ⅴ and Ⅵ drink 5% dextran sulfate (DSS) aqueous solution to induce intestinal inflammation in r...

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Abstract

The present invention firstly provides a kind of composition, described composition comprises goose oil diglyceride and oregano oil; The mass ratio of described oregano oil and goose oil diglyceride is 1:8~12; The present invention The composition is suitable for preparing repair preparations for treating colitis. The present invention also provides a repairing preparation for colitis, which is prepared by using the above-mentioned composition. It is a specific preparation method, which is to form a mixture of oregano oil and goose oil diglyceride, and put it in a magnetic heating stirrer. Keep the temperature at 30-50° C., rotate at 300-800 rpm, and stir for 3-8 minutes to complete the preparation. Tests have shown that the synergy between oregano oil and goose oil diglyceride can repair the colonic mucosa, promote the digestion and absorption of intestinal nutrients, and promote the recovery of rat body weight, greatly increase its enteritis repair effect, and reduce the need for drugs during disease treatment. Use to make it repair while avoiding the problem of drug residue.

Description

technical field [0001] The invention belongs to the technical field of enteritis treatment preparations, in particular to a non-antibiotic type colitis repair preparation. Background technique [0002] Ulcerative colitis (UC) is a clinical chronic non-specific inflammation. The lesions are often located in the colon, rectal mucosa and underlying tissues, and there are many causes. The disease lasts for a long time and is prone to repeated attacks. When suffering from this disease, symptoms such as abdominal pain, bloody diarrhea, blood in the stool, and weight loss are usually present. It is reported that the annual incidence of ulcerative colitis is 5 / 10-12 / 100,000, and the prevalence is 50 / 10-150 / 100,000. Its incidence is increasing day by day, and it seriously affects people's quality of life. Listed as one of the world's intractable diseases. At present, western medicine treatment is relatively limited, and aminosalicylic acids, immunosuppressants, microbial preparatio...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/215A61K36/53A61P1/00A61P1/04
CPCA61K31/215A61K36/53A61P1/00A61P1/04A61K2300/00
Inventor 王宝维谢玉娥刘亚楠葛文华张名爱孔敏
Owner QINGDAO AGRI UNIV
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